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SEQUENCES
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SEQUENCE ANALYSIS
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StabMutAnalyser
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&
ligands
LIGANDS & BIOACTIVITIES
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COUPLINGS
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SEQUENCES
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STRUCTURES
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COUPLINGS
Couplings
COUPLING ANALYSIS
Coupling selectivity (tree)
Coupling selectivity (Venn)
SEQUENCES
Sequence alignments
Generic residue number tables
STRUCTURES
Structure coverage
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DETERMINANTS & MUTATIONS
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Biased Signaling Atlas
Citing Biased Signaling Atlas
GUIDELINES
Community guidelines paper
Reference ligand selection
Template to calculate ligand bias factors
BIASED LIGANDS (for transducer family)
Biased ligand coverage
Biased ligands
Ligand bias rank orders
Ligand pathway profiles (Δlog(Emax/EC50))
Ligand pathway profiles (Δlog(Tau/KA))
BIASED LIGANDS (for transducer subtype)
Biased ligand coverage
Biased ligands
Ligand bias rank orders
Ligand pathway profiles (Δlog(Emax/EC50))
Ligand pathway profiles (Δlog(Tau/KA))
PATHWAY-PREFERRING LIGANDS (for transducer family)
Pathway-preferring ligand coverage
Pathway-preferring ligands (pathway ∆Log/(Emax/EC50)
Ligand pathway preference rank orders (Δlog(Emax/EC50))
Ligand pathway profiles (Log(Emax/EC50))
Pathways
Pathway effects
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Download
Excel (xlsx)
Alignment (fasta)
Spreadsheet (csv)
Residue number
Subdomain
Segment
Sequence-based (CAN)
Structure-based (ArrestinDb)
[Olive baboon] Beta-arrestin-1
[Green monkey] Beta-arrestin-1
[Dog] Beta-arrestin-1
[Bovine] Beta-arrestin-1
[Human] Beta-arrestin-1
[Crab-eating macaque] Beta-arrestin-1
[Mouse] Beta-arrestin-1
[Rabbit] Beta-arrestin-1
[Rat] Beta-arrestin-1
[Caenorhabditis elegans] Beta-arrestin arr-1
[Zebrafish] Beta-arrestin-1
[Pig] Beta-arrestin-1
[Horse] Beta-arrestin-1
[Giant panda] Beta-arrestin-1
[Northern white-cheeked gibbon] Beta-arrestin-1
[Western lowland gorilla] Beta-arrestin-1
[African elephant] Beta-arrestin-1
[Tasmanian devil] Beta-arrestin-1
[Guinea pig] Beta-arrestin-1
[Small-eared galago] Beta-arrestin-1
[Zebra finch] Beta-arrestin-1
[Chimpanzee] Beta-arrestin-1
[Cat] Beta-arrestin-2
[White-tufted-ear marmoset] Beta-arrestin-1
[Blind cave fish] Beta-arrestin-1
[Sheep] Beta-arrestin-1
Subdomain
Segment
Sequence-based (CAN)
Structure-based (ArrestinDb)
Seq consensus
Prop consensus
Length
RESIDUE PROPERTIES & LENGTH
Hydrophobic
HY
any
Hydrophobic
HY
4-5
Hydrophobic aliphatic
HA
any
Hydrophobic aliphatic
HA
1-2
Hydrophobic aliphatic
HA
2-3
Hydrophobic aliphatic
HA
3
Hydrophobic aliphatic
HA
3-4
Hydrophobic aliphatic [M]
M
4
Hydrophob al / α-H prop - very high [A]
A
1
Hydrophobic aliphatic [I]
I
Hydrophobic aliphatic [L]
L
Hydrophobic aliphatic [V]
V
Hydrophobic aromatic
HR
any
Hydrophobic aromatic
HR
4-5
Hydrophobic aromatic
HR
5
Hydrophobic aromatic
HR
5-6
Hydrophobic aromatic [W]
W
6
Hydropob ar / H-bonding [Y]
Y
Hydrophobic aromatic [F]
F
Hydrogen bonding (polar)
Hb
any
Hydrogen bonding
Hb
2
Hydrogen bonding
Hb
3
Hydrogen bonding [N]
N
Hydrogen bonding [Q]
Q
Hydrogen bonding [S]
S
Hydrogen bonding [T]
T
Hydrogen bonding uncharged
Hu
2-3
Hydrogen bonding uncharged
Hu
3-4
Hydrogen bond acceptor
Ha
2-3
Hydrogen bond acceptor
Ha
3
Hydrogen bond acceptor
Ha
3-4
Hydrogen bond acceptor
Ha
4
Hydrogen bond donor
Hd
4
Hydrogen bond donor
Hd
4-5
Hydrogen bond donor
Hd
5-6
Hydrogen bond donor
Hd
6
Charged
+-
any
Charged
+-
3-4
Charged
+-
4-5
Charged positive
+
any
Charged pos / H bond / Hphob ar [H]
H
4
Charged positive
+
4-5
Charged positive [K]
K
5
Charged positive
+
5-6
Charged positive [R]
R
6
Charged negative
-
any
Charged negative [D]
D
3
Charged negative [E]
E
4
Small
Sm
any
Small
Sm
0-1
Small
Sm
1-2
α-Helix propensity - high
αH
Hig
α-Helix propensity - low
αH
Min
α-Helix flexibility [G]
G
0
α-Helix kink [P]
P
2
Disulfide-forming (S-S) [C]
C
2
Gap (no amino acid)
-
RESIDUE Z-SCALES
Z1 (Lipophilicity)
Z2 (Steric properties)
Z3 (Electronic properties)
Z4 (PC1 several properties)
Z5 (PC2 several properties)
Subdomain
Segment
Sequence-based (CAN)
Structure-based (ArrestinDb)
N
ns1
-
.5
N
ns1
-
.6
N
ns1
-
.7
N
ns1
-
.8
N
ns1
-
.9
N
ns1
-
.10
N
ns1
-
.11
N
ns1
-
.12
N
ns1
-
.13
N
ns1
-
.14
N
ns1
-
.15
N
S1
-
.1
N
S1
-
.2
N
S1
-
.3
N
S1
-
.4
N
S1
-
.5
N
s1s2
-
.1
N
s1s2
-
.2
N
s1s2
-
.3
N
s1s2
-
.4
N
s1s2
-
.5
N
S2
-
.1
N
S2
-
.2
N
S2
-
.3
N
S2
-
.4
N
S2
-
.5
N
s2s3
-
.1
N
s2s3
-
.2
N
s2s3
-
.3
N
S3
-
.1
N
S3
-
.2
N
S3
-
.3
N
S3
-
.4
N
s3s4
-
.1
N
s3s4
-
.2
N
s3s4
-
.3
N
s3s4
-
.4
N
s3s4
-
.5
N
s3s4
-
.6
N
s3s4
-
.7
N
S4
-
.1
N
S4
-
.2
N
S4
-
.3
N
S4
-
.4
N
S4
-
.5
N
S4
-
.6
N
S4
-
.7
N
s4s5
-
.1
N
s4s5
-
.2
N
s4s5
-
.3
N
s4s5
-
.4
N
s4s5
-
.5
N
s4s5
-
.6
N
s4s5
-
.7
N
s4s5
-
.8
N
s4s5
-
.9
N
S5
-
.1
N
S5
-
.2
N
S5
-
.3
N
S5
-
.4
N
S5
-
.5
N
S5
-
.6
N
S5
-
.7
N
S5
-
.8
N
S5
-
.9
N
S5
-
.10
N
S5
-
.11
N
S5
-
.12
N
s5s6
-
.1
N
s5s6
-
.2
N
s5s6
-
.3
N
s5s6
-
.4
N
s5s6
-
.5
N
s5s6
-
.6
N
s5s6
-
.7
N
s5s6
-
.8
N
s5s6
-
.9
N
s5s6
-
.10
N
s5s6
-
.11
N
S6
-
.1
N
S6
-
.2
N
S6
-
.3
N
S6
-
.4
N
S6
-
.5
N
S6
-
.6
N
S6
-
.7
N
S6
-
.8
N
S6
-
.9
N
S6
-
.10
N
S6
-
.11
N
S6
-
.12
N
S6
-
.13
N
s6h1
-
.1
N
s6h1
-
.2
N
s6h1
-
.3
N
s6h1
-
.4
N
s6h1
-
.5
N
s6h1
-
.6
N
s6h1
-
.7
N
s6h1
-
.8
N
s6h1
-
.9
N
s6h1
-
.10
N
s6h1
-
.11
N
s6h1
-
.12
N
H1
-
.1
N
H1
-
.2
N
H1
-
.3
N
H1
-
.4
N
H1
-
.5
N
H1
-
.6
N
H1
-
.7
N
H1
-
.8
N
H1
-
.9
N
H1
-
.10
N
h1s7
-
.1
N
h1s7
-
.2
N
h1s7
-
.3
N
S7
-
.1
N
S7
-
.2
N
S7
-
.3
N
S7
-
.4
N
S7
-
.5
N
S7
-
.6
N
s7s8
-
.1
N
s7s8
-
.2
N
s7s8
-
.3
N
s7s8
-
.4
N
s7s8
-
.5
N
s7s8
-
.6
N
s7s8
-
.7
N
s7s8
-
.8
N
s7s8
-
.9
N
S8
-
.1
N
S8
-
.2
N
S8
-
.3
N
s8s9
-
.1
N
s8s9
-
.2
N
s8s9
-
.3
N
s8s9
-
.4
N
s8s9
-
.5
N
s8s9
-
.6
N
s8s9
-
.7
N
s8s9
-
.8
N
s8s9
-
.9
N
s8s9
-
.10
N
S9
-
.1
N
S9
-
.2
N
S9
-
.3
N
S9
-
.4
N
S9
-
.5
N
S9
-
.6
N
S9
-
.7
N
S9
-
.8
N
S9
-
.9
N
S9
-
.10
N
S9
-
.11
N
S9
-
.12
N
s9s10
-
.1
N
s9s10
-
.2
N
s9s10
-
.3
N
s9s10
-
.4
N
s9s10
-
.5
N
s9s10
-
.6
N
s9s10
-
.7
N
s9s10
-
.8
N
s9s10
-
.9
N
s9s10
-
.10
N
s9s10
-
.11
N
s9s10
-
.12
N
s9s10
-
.13
N
s9s10
-
.14
N
s9s10
-
.15
N
s9s10
-
.16
N
s9s10
-
.17
N
S10
-
.1
N
S10
-
.2
N
S10
-
.3
N
S10
-
.4
N
S10
-
.5
N
S10
-
.6
N
S10
-
.7
N
S10
-
.8
N
S10
-
.9
N
S10
-
.10
N
S10
-
.11
C
s10s11
-
.1
C
s10s11
-
.2
C
s10s11
-
.3
C
s10s11
-
.4
C
s10s11
-
.5
C
s10s11
-
.6
C
s10s11
-
.7
C
s10s11
-
.8
C
s10s11
-
.9
C
s10s11
-
.10
C
S11
-
.1
C
S11
-
.2
C
S11
-
.3
C
S11
-
.4
C
S11
-
.5
C
S11
-
.6
C
s11s12
-
.1
C
s11s12
-
.2
C
s11s12
-
.3
C
s11s12
-
.4
C
s11s12
-
.5
C
s11s12
-
.6
C
s11s12
-
.7
C
S12
-
.1
C
S12
-
.2
C
S12
-
.3
C
S12
-
.4
C
S12
-
.5
C
S12
-
.6
C
S12
-
.7
C
s12s13
-
.1
C
s12s13
-
.2
C
s12s13
-
.3
C
S13
-
.1
C
S13
-
.2
C
S13
-
.3
C
s13s14
-
.1
C
s13s14
-
.2
C
s13s14
-
.3
C
s13s14
-
.4
C
S14
-
.1
C
S14
-
.2
C
S14
-
.3
C
S14
-
.4
C
S14
-
.5
C
S14
-
.6
C
S14
-
.7
C
S14
-
.8
C
S14
-
.9
C
s14s15
-
.1
C
s14s15
-
.2
C
s14s15
-
.3
C
s14s15
-
.4
C
s14s15
-
.5
C
S15
-
.1
C
S15
-
.2
C
S15
-
.3
C
S15
-
.4
C
S15
-
.5
C
S15
-
.6
C
S15
-
.7
C
S15
-
.8
C
S15
-
.9
C
S15
-
.10
C
S15
-
.11
C
S15
-
.12
C
S15
-
.13
C
S15
-
.14
C
s15s16
-
.1
C
s15s16
-
.2
C
s15s16
-
.3
C
s15s16
-
.4
C
s15s16
-
.5
C
S16
-
.1
C
S16
-
.2
C
S16
-
.3
C
S16
-
.4
C
S16
-
.5
C
S16
-
.6
C
S16
-
.7
C
S16
-
.8
C
S16
-
.9
C
S16
-
.10
C
S16
-
.11
C
S16
-
.12
C
S16
-
.13
C
S16
-
.14
C
s16s17
-
.1
C
s16s17
-
.2
C
s16s17
-
.3
C
s16s17
-
.4
C
s16s17
-
.5
C
s16s17
-
.6
C
s16s17
-
.7
C
S17
-
.1
C
S17
-
.2
C
S17
-
.3
C
S17
-
.4
C
S17
-
.5
C
S17
-
.6
C
S17
-
.7
C
S17
-
.8
C
S17
-
.9
C
s17s18
-
.1
C
s17s18
-
.2
C
s17s18
-
.3
C
s17s18
-
.4
C
s17s18
-
.5
C
s17s18
-
.6
C
s17s18
-
.7
C
s17s18
-
.8
C
s17s18
-
.9
C
s17s18
-
.10
C
s17s18
-
.11
C
s17s18
-
.12
C
s17s18
-
.13
C
s17s18
-
.14
C
s17s18
-
.15
C
s17s18
-
.16
C
s17s18
-
.17
C
s17s18
-
.18
C
s17s18
-
.19
C
s17s18
-
.20
C
s17s18
-
.21
C
s17s18
-
.22
C
s17s18
-
.23
C
s17s18
-
.24
C
s17s18
-
.25
C
s17s18
-
.26
C
s17s18
-
.27
C
s17s18
-
.28
C
s17s18
-
.29
C
s17s18
-
.30
C
s17s18
-
.31
C
s17s18
-
.32
C
s17s18
-
.33
C
s17s18
-
.34
C
s17s18
-
.35
C
s17s18
-
.36
C
s17s18
-
.37
C
s17s18
-
.38
C
s17s18
-
.39
C
s17s18
-
.40
C
s17s18
-
.41
C
s17s18
-
.42
C
S18
-
.1
C
S18
-
.2
C
S18
-
.3
C
S18
-
.4
C
S18
-
.5
C
S18
-
.6
C
S18
-
.7
C
S18
-
.8
C
S18
-
.9
C
S18
-
.10
C
S18
-
.11
C
S18
-
.12
C
S18
-
.13
C
s18s19
-
.1
C
s18s19
-
.2
C
s18s19
-
.3
C
s18s19
-
.4
C
s18s19
-
.5
C
s18s19
-
.6
C
s18s19
-
.7
C
s18s19
-
.8
C
s18s19
-
.9
C
s18s19
-
.10
C
s18s19
-
.11
C
S19
-
.1
C
S19
-
.2
C
S19
-
.3
C
S19
-
.4
C
S19
-
.5
C
S19
-
.6
C
S19
-
.7
C
S19
-
.8
C
S19
-
.9
C
S19
-
.10
C
S19
-
.11
C
S19
-
.12
C
S19
-
.13
C
s19s20
-
.1
C
s19s20
-
.2
C
s19s20
-
.3
C
s19s20
-
.4
C
s19s20
-
.5
C
s19s20
-
.6
C
s19s20
-
.7
C
s19s20
-
.8
C
s19s20
-
.9
C
s19s20
-
.10
C
s19s20
-
.11
C
s19s20
-
.12
C
s19s20
-
.13
C
s19s20
-
.14
C
s19s20
-
.15
C
s19s20
-
.16
C
s19s20
-
.17
C
s19s20
-
.18
C
s19s20
-
.19
C
s19s20
-
.20
C
s19s20
-
.28
C
s19s20
-
.29
C
s19s20
-
.30
C
s19s20
-
.31
C
s19s20
-
.32
C
s19s20
-
.33
C
s19s20
-
.34
C
s19s20
-
.35
C
s19s20
-
.36
C
s19s20
-
.37
C
s19s20
-
.38
C
s19s20
-
.39
C
s19s20
-
.40
C
s19s20
-
.41
C
s19s20
-
.42
C
s19s20
-
.43
C
s19s20
-
.44
C
s19s20
-
.45
C
s19s20
-
.46
C
s19s20
-
.47
C
s19s20
-
.48
C
s19s20
-
.49
C
s19s20
-
.50
C
s19s20
-
.51
C
S20
-
.1
C
S20
-
.2
C
S20
-
.3
C
S20
-
.4
C
S20
-
.5
C
s20c
-
.1
C
s20c
-
.2
C
s20c
-
.3
C
s20c
-
.4
C
s20c
-
.5
C
s20c
-
.6
C
s20c
-
.7
C
s20c
-
.8
C
s20c
-
.9
C
s20c
-
.10
C
s20c
-
.11
C
s20c
-
.12
C
s20c
-
.13
C
s20c
-
.14
C
s20c
-
.15
C
s20c
-
.16
C
s20c
-
.17
C
s20c
-
.18
C
s20c
-
.19
C
s20c
-
.20
C
s20c
-
.21
C
s20c
-
.22
C
s20c
-
.23
C
s20c
-
.24
C
s20c
-
.25
C
s20c
-
.26
C
s20c
-
.27
C
s20c
-
.28
-
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