grm5_human
NAME
6N52
ORGANISM
Human (Homo sapiens)
PROTEIN NAME
grm5_human
SOURCE
SWISSPROT
SEQUENCE
Perspective:
Wild-type
Construct
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N-term | |||||||||
M
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V
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L
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L
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L
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I
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L
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S
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V
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L
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10 |
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|
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L
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L
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K
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E
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D
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V
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R
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G
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S
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A
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20 |
Q
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S
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S
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E
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R
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R
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V
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V
|
A
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H
|
30 |
M
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P
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G
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D
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I
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I
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I
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G
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A
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L
|
40 |
F
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S
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V
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H
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H
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Q
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P
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T
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V
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D
|
50 |
K
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V
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H
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E
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R
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K
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C
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G
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A
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V
|
60 |
R
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E
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Q
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Y
|
G
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I
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Q
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R
|
V
|
E
|
70 |
A
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M
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L
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H
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T
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L
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E
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R
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I
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N
|
80 |
S
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D
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P
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T
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L
|
L
|
P
|
N
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I
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T
|
90 |
L
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G
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C
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E
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I
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R
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D
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S
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C
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W
|
100 |
H
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S
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A
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V
|
A
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L
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E
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Q
|
S
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I
|
110 |
E
|
F
|
I
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R
|
D
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S
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L
|
I
|
S
|
S
|
120 |
E
|
E
|
E
|
E
|
G
|
L
|
V
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R
|
C
|
V
|
130 |
D
|
G
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S
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S
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S
|
S
|
F
|
R
|
S
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K
|
140 |
K
|
P
|
I
|
V
|
G
|
V
|
I
|
G
|
P
|
G
|
150 |
S
|
S
|
S
|
V
|
A
|
I
|
Q
|
V
|
Q
|
N
|
160 |
L
|
L
|
Q
|
L
|
F
|
N
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I
|
P
|
Q
|
I
|
170 |
A
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Y
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S
|
A
|
T
|
S
|
M
|
D
|
L
|
S
|
180 |
D
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K
|
T
|
L
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F
|
K
|
Y
|
F
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M
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R
|
190 |
V
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V
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P
|
S
|
D
|
A
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Q
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Q
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A
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R
|
200 |
A
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M
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V
|
D
|
I
|
V
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K
|
R
|
Y
|
N
|
210 |
W
|
T
|
Y
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V
|
S
|
A
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V
|
H
|
T
|
E
|
220 |
G
|
N
|
Y
|
G
|
E
|
S
|
G
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M
|
E
|
A
|
230 |
F
|
K
|
D
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M
|
S
|
A
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K
|
E
|
G
|
I
|
240 |
C
|
I
|
A
|
H
|
S
|
Y
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K
|
I
|
Y
|
S
|
250 |
N
|
A
|
G
|
E
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Q
|
S
|
F
|
D
|
K
|
L
|
260 |
L
|
K
|
K
|
L
|
T
|
S
|
H
|
L
|
P
|
K
|
270 |
A
|
R
|
V
|
V
|
A
|
C
|
F
|
C
|
E
|
G
|
280 |
M
|
T
|
V
|
R
|
G
|
L
|
L
|
M
|
A
|
M
|
290 |
R
|
R
|
L
|
G
|
L
|
A
|
G
|
E
|
F
|
L
|
300 |
L
|
L
|
G
|
S
|
D
|
G
|
W
|
A
|
D
|
R
|
310 |
Y
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D
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V
|
T
|
D
|
G
|
Y
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Q
|
R
|
E
|
320 |
A
|
V
|
G
|
G
|
I
|
T
|
I
|
K
|
L
|
Q
|
330 |
S
|
P
|
D
|
V
|
K
|
W
|
F
|
D
|
D
|
Y
|
340 |
Y
|
L
|
K
|
L
|
R
|
P
|
E
|
T
|
N
|
H
|
350 |
R
|
N
|
P
|
W
|
F
|
Q
|
E
|
F
|
W
|
Q
|
360 |
H
|
R
|
F
|
Q
|
C
|
R
|
L
|
E
|
G
|
F
|
370 |
P
|
Q
|
E
|
N
|
S
|
K
|
Y
|
N
|
K
|
T
|
380 |
C
|
N
|
S
|
S
|
L
|
T
|
L
|
K
|
T
|
H
|
390 |
H
|
V
|
Q
|
D
|
S
|
K
|
M
|
G
|
F
|
V
|
400 |
I
|
N
|
A
|
I
|
Y
|
S
|
M
|
A
|
Y
|
G
|
410 |
L
|
H
|
N
|
M
|
Q
|
M
|
S
|
L
|
C
|
P
|
420 |
G
|
Y
|
A
|
G
|
L
|
C
|
D
|
A
|
M
|
K
|
430 |
P
|
I
|
D
|
G
|
R
|
K
|
L
|
L
|
E
|
S
|
440 |
L
|
M
|
K
|
T
|
N
|
F
|
T
|
G
|
V
|
S
|
450 |
G
|
D
|
T
|
I
|
L
|
F
|
D
|
E
|
N
|
G
|
460 |
D
|
S
|
P
|
G
|
R
|
Y
|
E
|
I
|
M
|
N
|
470 |
F
|
K
|
E
|
M
|
G
|
K
|
D
|
Y
|
F
|
D
|
480 |
Y
|
I
|
N
|
V
|
G
|
S
|
W
|
D
|
N
|
G
|
490 |
E
|
L
|
K
|
M
|
D
|
D
|
D
|
E
|
V
|
W
|
500 |
S
|
K
|
K
|
S
|
N
|
I
|
I
|
R
|
S
|
V
|
510 |
C
|
S
|
E
|
P
|
C
|
E
|
K
|
G
|
Q
|
I
|
520 |
K
|
V
|
I
|
R
|
K
|
G
|
E
|
V
|
S
|
C
|
530 |
C
|
W
|
T
|
C
|
T
|
P
|
C
|
K
|
E
|
N
|
540 |
E
|
Y
|
V
|
F
|
D
|
E
|
Y
|
T
|
C
|
K
|
550 |
A
|
C
|
Q
|
L
|
G
|
S
|
W
|
P
|
T
|
D
|
560 |
D
|
L
|
T
|
G
|
C
|
D
|
L
|
I
|
P
|
V
|
570 |
TM1 | |||||||||
Q
|
Y
|
L
|
R
|
W
|
G
|
D
|
P
|
E
|
P
|
580 |
I
|
A
|
A
|
V
|
V
|
F
|
A
|
C
|
L
|
G
|
590 |
L
|
L
|
A
|
T
|
L
|
F
|
V
|
T
|
V
|
V
|
600 |
ICL1 | |||||||||
F
|
I
|
I
|
Y
|
R
|
D
|
T
|
P
|
V
|
V
|
610 |
TM2 | |||||||||
K
|
S
|
S
|
S
|
R
|
E
|
L
|
C
|
Y
|
I
|
620 |
I
|
L
|
A
|
G
|
I
|
C
|
L
|
G
|
Y
|
L
|
630 |
ECL1 | |||||||||
C
|
T
|
F
|
C
|
L
|
I
|
A
|
K
|
P
|
K
|
640 |
TM3 | |||||||||
Q
|
I
|
Y
|
C
|
Y
|
L
|
Q
|
R
|
I
|
G
|
650 |
I
|
G
|
L
|
S
|
P
|
A
|
M
|
S
|
Y
|
S
|
660 |
A
|
L
|
V
|
T
|
K
|
T
|
N
|
R
|
I
|
A
|
670 |
ICL2 | |||||||||
R
|
I
|
L
|
A
|
G
|
S
|
K
|
K
|
K
|
I
|
680 |
C
|
T
|
K
|
K
|
P
|
R
|
F
|
M
|
S
|
A
|
690 |
TM4 | |||||||||
C
|
A
|
Q
|
L
|
V
|
I
|
A
|
F
|
I
|
L
|
700 |
I
|
C
|
I
|
Q
|
L
|
G
|
I
|
I
|
V
|
A
|
710 |
ECL2 | |||||||||
L
|
F
|
I
|
M
|
E
|
P
|
P
|
D
|
I
|
M
|
720 |
H
|
D
|
Y
|
P
|
S
|
I
|
R
|
E
|
V
|
Y
|
730 |
TM5 | |||||||||
L
|
I
|
C
|
N
|
T
|
T
|
N
|
L
|
G
|
V
|
740 |
V
|
T
|
P
|
L
|
G
|
Y
|
N
|
G
|
L
|
L
|
750 |
I
|
L
|
S
|
C
|
T
|
F
|
Y
|
A
|
F
|
K
|
760 |
ICL3 | |||||||||
T
|
R
|
N
|
V
|
P
|
A
|
N
|
F
|
N
|
E
|
770 |
TM6 | |||||||||
A
|
K
|
Y
|
I
|
A
|
F
|
T
|
M
|
Y
|
T
|
780 |
T
|
C
|
I
|
I
|
W
|
L
|
A
|
F
|
V
|
P
|
790 |
ECL3 | TM7 | ||||||||||
I
|
Y
|
F
|
G
|
S
|
N
|
Y
|
K
|
I
|
I
|
||
800 |
T
|
M
|
C
|
F
|
S
|
V
|
S
|
L
|
S
|
A
|
810 |
T
|
V
|
A
|
L
|
G
|
C
|
M
|
F
|
V
|
P
|
820 |
H8 | |||||||||
K
|
V
|
Y
|
I
|
I
|
L
|
A
|