GNAO

CLASSIFICATION

G-Protein Alpha Gi/o GNAO

NO. OF PROTEINS

24 (1 human)

ALIGNMENT

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SEQUENCE

G.HN            
M
G
C
T
L
S
A
E
E
R
10
                   
A
A
L
E
R
S
K
A
I
E
20
                   
K
N
L
K
E
D
G
I
S
A
30
G.hns1 G.S1
A
K
D
V
K
L
L
L
L
G
40
G.s1h1 G.H1
A
G
E
S
G
K
S
T
I
V
50
                   
K
Q
M
K
I
I
H
E
D
G
60
G.h1ha H.HA
F
S
G
E
D
V
K
Q
Y
K
70
                   
P
V
V
Y
S
N
T
I
Q
S
80
                   
L
A
A
I
V
R
A
M
D
T
90
  H.hahb      
L
G
I
E
Y
G
D
K
E
R
100
H.HB            
K
A
D
A
K
M
V
C
D
V
110
    H.hbhc    
V
S
R
M
E
D
T
E
P
F
120
  H.HC          
S
A
E
L
L
S
A
M
M
R
130
      H.hchd H.HD
L
W
G
D
S
G
I
Q
E
C
140
             
F
N
R
S
R
E
Y
Q
L
N
150
H.hdhe H.HE
D
S
A
K
Y
Y
L
D
S
L
160
        H.hehf
D
R
I
G
A
A
D
Y
Q
P
170
  H.HF          
T
E
Q
D
I
L
R
T
R
V
180
G.hfs2 G.S2
K
T
T
G
I
V
E
T
H
F
190
    G.s2s3 G.S3
T
F
K
N
L
H
F
R
L
F
200
G.s3h2 G.H2
D
V
G
G
Q
R
S
E
R
K
210
               
K
W
I
H
C
F
E
D
V
T
220
G.S4            
A
I
I
F
C
V
A
L
S
G
230
G.s4h3        
Y
D
Q
V
L
H
E
D
E
T
240
    G.H3        
T
N
R
M
H
E
S
L
M
L
250
                   
F
D
S
I
C
N
N
K
F
F
260
G.h3s5 G.S5
I
D
T
S
I
I
L
F
L
N
270
G.s5hg G.HG
K
K
D
L
F
G
E
K
I
K
280
                   
K
S
P
L
T
I
C
F
P
E
290
G.hgh4 G.H4
Y
T
G
P
N
T
Y
E
D
A
300
                   
A
A
Y
I
Q
A
Q
F
E
S
310
G.h4s6        
K
N
R
S
P
N
K
E
I
Y
320
G.S6 G.s6h5
C
H
M
T
C
A
T
D
T
N
330
G.H5            
N
I
Q
V
V
F
D
A
V
T
340
                   
D
I
I
I
A
N
N
L
R
G
350
       
C
G
L
Y

DIAGRAMS


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Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
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Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
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MUTATIONS

0 mutation data points available.

STRUCTURES

No structures available