PDB
10TL
Resolution
3.5 Å
Released
May 27, 2026
Receptor
μ
Class
A
Species
Homo sapiens
Ligands
BMS-986187
DAMGO
Function
PAM
Agonist
Reference
—
BMS-986187 DAMGO

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Ligand Amino Acid Generic Number Segment Interaction Type
BMS-986187 L118 2.52x52 TM2 hydrophobic
BMS-986187 I144 3.27x27 TM3 hydrophobic
DAMGO I146 3.29x29 TM3 hydrophobic
BMS-986187 S147 3.30x30 TM3 Van der Waals
BMS-986187 S147 3.30x30 TM3 polar (hydrogen bond)
BMS-986187 I148 3.31x31 TM3 hydrophobic
BMS-986187 I148 3.31x31 TM3 Van der Waals
BMS-986187 Y151 3.34x34 TM3 hydrophobic
BMS-986187 Y151 3.34x34 TM3 Van der Waals
BMS-986187 W194 4.50x50 TM4 hydrophobic
BMS-986187 G201 4.57x57 TM4 Van der Waals
BMS-986187 L202 4.58x58 TM4 hydrophobic
BMS-986187 L202 4.58x58 TM4 Van der Waals
BMS-986187 M205 4.61x61 TM4 Van der Waals
DAMGO W320 7.35x34 TM7 hydrophobic
DAMGO Y328 7.43x42 TM7 polar (hydrogen bond)

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Snake plot — Download: PNG | SVG
ICL1 T K M K ICL1ECL1 T W P F ECL1ICL2 P V K A L D F R ICL2ECL2 T T K Y R Q G S I D C T L T F S H ECL2ICL3 R M L S G ICL3ECL3 T I P E ECL3N-term M D S S A A P T N A S N C T D A L A Y S S C S P A P S P G S W V N L S H L D G N L S D P C G P N R T D L G G R D S L C P P T G S P S N-termC-term P T S S N I E Q Q N S T R I R Q N T R D H P S T A N T V D R T N H Q L E N L E A E T A P L P C-term M I T A I T I M A L Y S I V C V V G L F G N F L V M Y V I V R Y T A T N I Y I F N L A L A D A L A T S T L P F Q S V N Y L M G G T I L C K I V I S I D Y Y N M F T S I F T L C T M S V D R Y I A V C H T P R N A K I I N V C N W I L S S A I G L P V M F M A P T W Y W E N L L K I C V F I F A F I M P V L I I T V C Y G L M I L R L K S V S K E K D R N L R R I T R M V L V V V A V F I V C W T P I H I Y V I I K A L V T T F Q T V S W H F C I A L G Y T N S C L N P V L Y A F L D E N F R E F K R C F C I
Helix box plot — Download: PNG | SVG F N G F L G V V C V I S Y L A M I T I A 1 F N L A L A D A L A T S T L P F Q S V N 2 T C L T F I S T F M N Y Y D I S I V I K 3 A K I I N V C N W I L S S A I G L P V M 4 Y C V T I I L V P M I F A F I F V C I K L 5 L V V V A V F I V C W T P I H I Y V I I 6 V P N L C S N T Y G L A I C F H W S V 7

GPCRdb(A)
GPCRdb(A)
μ receptor
TM2
2x52 2.52x52 L118
TM3
3x27 3.27x27 I144
3x29 3.29x29 I146
3x30 3.30x30 S147
3x31 3.31x31 I148
3x34 3.34x34 Y151
TM4
4x50 4.50x50 W194
4x57 4.57x57 G201
4x58 4.58x58 L202
4x61 4.61x61 M205
TM7
7x34 7.35x34 W320
7x42 7.43x42 Y328