PDB
11TF
Resolution
3.4 Å
Released
April 1, 2026
Receptor
CCR4
Class
A
Species
Homo sapiens
Ligand
zelnecirnon
Function
Antagonist
Reference
—

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Ligand Amino Acid Generic Number Segment Interaction Type
zelnecirnon W95 2.60x60 TM2 hydrophobic
zelnecirnon Y98 2.63x63 TM2 polar (hydrogen bond)
zelnecirnon Y117 3.32x32 TM3 Van der Waals
zelnecirnon Y117 3.32x32 TM3 hydrophobic
zelnecirnon L118 3.33x33 TM3 hydrophobic
zelnecirnon L118 3.33x33 TM3 Van der Waals
zelnecirnon F121 3.36x36 TM3 Van der Waals
zelnecirnon F121 3.36x36 TM3 aromatic (face-to-face)
zelnecirnon Y122 3.37x37 TM3 Van der Waals
zelnecirnon K188 45.51x51 ECL2 polar (charge-assisted hydrogen bond)
zelnecirnon I206 5.42x43 TM5 hydrophobic
zelnecirnon I206 5.42x43 TM5 Van der Waals
zelnecirnon N207 5.43x44 TM5 Van der Waals
zelnecirnon W370 6.48x48 TM6 hydrophobic
zelnecirnon W370 6.48x48 TM6 Van der Waals
zelnecirnon Y373 6.51x51 TM6 Van der Waals
zelnecirnon Y373 6.51x51 TM6 hydrophobic
zelnecirnon N374 6.52x52 TM6 Van der Waals
zelnecirnon L377 6.55x55 TM6 hydrophobic
zelnecirnon L377 6.55x55 TM6 Van der Waals
zelnecirnon Q402 7.36x35 TM7 Van der Waals
zelnecirnon E405 7.39x38 TM7 Van der Waals

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Snake plot — Download: PNG | SVG
ICL1 K R L R ICL1ECL1 Q W V F ECL1ICL2 A V F S L R A R ICL2ECL2 T C Y T E R N H T Y C K T K Y S L ECL2ICL3 K N ICL3ECL3 L Q ECL3N-term M N P T D I A D T T L D E S I Y S N Y Y L Y E S I P K P C T N-termC-term T C R G L F V L C Q Y C G L L Q I Y S A D T P S S S Y T Q S T M D H D L H D A L C-term K E G I K A F G E L F L P P L Y S L V F V F G L L G N S V V V L V L F K Y S M T D V Y L L N L A I S D L L F V F S L P F W G Y Y A A D G L G L C K M I S W M Y L V G F Y S G I F F V M L M S I D R Y L A I V H T L T Y G V I T S L A T W S V A V F A S L P G F L F S N S T T W K V L S S L E I N I L G L V I P L G I M L F C Y S M I I R T L Q H C E K K N K A V K M I F A V V V L F L G F W T P Y N I V L F L E T L V E L E V D C T F E R Y L D Y A I Q A T E T L A F V H C C L N P I I Y F F L G E K I L Q F R K Y L F K
Helix box plot — Download: PNG | SVG S N G L L G F V F V L S Y L P P L F L E 1 L N L A I S D L L F V F S L P F W G Y Y 2 L M V F F I G S Y F G V L Y M W S I M K 3 G V I T S L A T W S V A V F A S L P G 4 Y C F L M I G L P I V L G L I N I E L S S 5 F A V V V L F L G F W T P Y N I V L F L 6 I P N L C C H V F A L T E T A Q I A Y 7

GPCRdb(A)
GPCRdb(A)
CCR4
TM2
2x60 2.60x60 W95
2x63 2.63x63 Y98
TM3
3x32 3.32x32 Y117
3x33 3.33x33 L118
3x36 3.36x36 F121
3x37 3.37x37 Y122
ECL2
45x51 45.51x51 K188
TM5
5x43 5.42x43 I206
5x44 5.43x44 N207
TM6
6x48 6.48x48 W255
6x51 6.51x51 Y258
6x52 6.52x52 N259
6x55 6.55x55 L262
TM7
7x35 7.36x35 Q287
7x38 7.39x38 E290