PDB
11TH
Resolution
3.5 Å
Released
April 1, 2026
Receptor
CCR4
Class
A
Species
Homo sapiens
Ligand
FLX475
Function
Antagonist
Reference
—

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Ligand Amino Acid Generic Number Segment Interaction Type
FLX475 W95 2.60x60 TM2 hydrophobic
FLX475 Y117 3.32x32 TM3 hydrophobic
FLX475 L118 3.33x33 TM3 hydrophobic
FLX475 F121 3.36x36 TM3 aromatic (face-to-face)
FLX475 I206 5.42x43 TM5 hydrophobic
FLX475 N207 5.43x44 TM5 polar (hydrogen bond)
FLX475 W370 6.48x48 TM6 Van der Waals
FLX475 W370 6.48x48 TM6 hydrophobic
FLX475 Y373 6.51x51 TM6 hydrophobic
FLX475 Y373 6.51x51 TM6 Van der Waals
FLX475 N374 6.52x52 TM6 Van der Waals
FLX475 L377 6.55x55 TM6 Van der Waals
FLX475 L377 6.55x55 TM6 hydrophobic
FLX475 E405 7.39x38 TM7 polar (charge-assisted hydrogen bond)
FLX475 F409 7.43x42 TM7 Van der Waals
FLX475 F409 7.43x42 TM7 hydrophobic

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ICL1 K R L R ICL1ECL1 Q W V F ECL1ICL2 A V F S L R A R ICL2ECL2 T C Y T E R N H T Y C K T K Y S L ECL2ICL3 K N ICL3ECL3 L Q ECL3N-term M N P T D I A D T T L D E S I Y S N Y Y L Y E S I P K P C T N-termC-term T C R G L F V L C Q Y C G L L Q I Y S A D T P S S S Y T Q S T M D H D L H D A L C-term K E G I K A F G E L F L P P L Y S L V F V F G L L G N S V V V L V L F K Y S M T D V Y L L N L A I S D L L F V F S L P F W G Y Y A A D G L G L C K M I S W M Y L V G F Y S G I F F V M L M S I D R Y L A I V H T L T Y G V I T S L A T W S V A V F A S L P G F L F S N S T T W K V L S S L E I N I L G L V I P L G I M L F C Y S M I I R T L Q H C E K K N K A V K M I F A V V V L F L G F W T P Y N I V L F L E T L V E L E V D C T F E R Y L D Y A I Q A T E T L A F V H C C L N P I I Y F F L G E K I L Q F R K Y L F K
Helix box plot — Download: PNG | SVG S N G L L G F V F V L S Y L P P L F L E 1 L N L A I S D L L F V F S L P F W G Y Y 2 L M V F F I G S Y F G V L Y M W S I M K 3 G V I T S L A T W S V A V F A S L P G 4 Y C F L M I G L P I V L G L I N I E L S S 5 F A V V V L F L G F W T P Y N I V L F L 6 I P N L C C H V F A L T E T A Q I A Y 7

GPCRdb(A)
GPCRdb(A)
CCR4
TM2
2x60 2.60x60 W95
TM3
3x32 3.32x32 Y117
3x33 3.33x33 L118
3x36 3.36x36 F121
TM5
5x43 5.42x43 I206
5x44 5.43x44 N207
TM6
6x48 6.48x48 W255
6x51 6.51x51 Y258
6x52 6.52x52 N259
6x55 6.55x55 L262
TM7
7x38 7.39x38 E290
7x42 7.43x42 F294