PDB
11TL
Resolution
3.9 Å
Released
April 1, 2026
Receptor
CCR4
Class
A
Species
Homo sapiens
Ligand
GSK2239633A
Function
Antagonist
Reference
—

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Ligand Amino Acid Generic Number Segment Interaction Type
GSK2239633A V60 1.53x53 TM1 hydrophobic
GSK2239633A V63 1.56x56 TM1 hydrophobic
GSK2239633A L64 1.57x57 TM1 hydrophobic
GSK2239633A A355 6.33x33 TM6 hydrophobic
GSK2239633A M358 6.36x36 TM6 polar (hydrogen bond)
GSK2239633A I359 6.37x37 TM6 hydrophobic
GSK2239633A I359 6.37x37 TM6 Van der Waals
GSK2239633A Y419 7.53x53 TM7 Van der Waals
GSK2239633A Y419 7.53x53 TM7 hydrophobic
GSK2239633A E424 ICL4 polar (hydrogen bond with backbone)
GSK2239633A E424 ICL4 Van der Waals
GSK2239633A K425 8.49x49 H8 polar (hydrogen bond with backbone)
GSK2239633A K425 8.49x49 H8 Van der Waals
GSK2239633A F426 8.50x50 H8 Van der Waals
GSK2239633A F426 8.50x50 H8 hydrophobic

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Snake plot — Download: PNG | SVG
ICL1 K R L R ICL1ECL1 Q W V F ECL1ICL2 A V F S L R A R ICL2ECL2 T C Y T E R N H T Y C K T K Y S L ECL2ICL3 K N ICL3ECL3 L Q ECL3N-term M N P T D I A D T T L D E S I Y S N Y Y L Y E S I P K P C T N-termC-term T C R G L F V L C Q Y C G L L Q I Y S A D T P S S S Y T Q S T M D H D L H D A L C-term K E G I K A F G E L F L P P L Y S L V F V F G L L G N S V V V L V L F K Y S M T D V Y L L N L A I S D L L F V F S L P F W G Y Y A A D G L G L C K M I S W M Y L V G F Y S G I F F V M L M S I D R Y L A I V H T L T Y G V I T S L A T W S V A V F A S L P G F L F S N S T T W K V L S S L E I N I L G L V I P L G I M L F C Y S M I I R T L Q H C E K K N K A V K M I F A V V V L F L G F W T P Y N I V L F L E T L V E L E V D C T F E R Y L D Y A I Q A T E T L A F V H C C L N P I I Y F F L G E K I L Q F R K Y L F K
Helix box plot — Download: PNG | SVG S N G L L G F V F V L S Y L P P L F L E 1 L N L A I S D L L F V F S L P F W G Y Y 2 L M V F F I G S Y F G V L Y M W S I M K 3 G V I T S L A T W S V A V F A S L P G 4 Y C F L M I G L P I V L G L I N I E L S S 5 F A V V V L F L G F W T P Y N I V L F L 6 I P N L C C H V F A L T E T A Q I A Y 7

GPCRdb(A)
GPCRdb(A)
CCR4
TM1
1x53 1.53x53 V60
1x56 1.56x56 V63
1x57 1.57x57 L64
TM6
6x33 6.33x33 A240
6x36 6.36x36 M243
6x37 6.37x37 I244
TM7
7x53 7.53x53 Y304
H8
8x49 8.49x49 K310
8x50 8.50x50 F311