PDB
12JA
Resolution
2.9 Å
Released
July 15, 2026
Receptor
CB2
Class
A
Species
Homo sapiens
Ligand
'1029
Function
Agonist
Reference
—

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Ligand Amino Acid Generic Number Segment Interaction Type
'1029 F87 2.57x57 TM2 hydrophobic
'1029 F91 2.61x61 TM2 hydrophobic
'1029 F94 2.64x64 TM2 hydrophobic
'1029 V113 3.32x32 TM3 hydrophobic
'1029 T114 3.33x33 TM3 polar (hydrogen bond)
'1029 T114 3.33x33 TM3 polar (hydrogen bond)
'1029 F183 ECL2 hydrophobic
'1029 F183 ECL2 Van der Waals
'1029 Y190 5.39x39 TM5 hydrophobic
'1029 Y190 5.39x39 TM5 Van der Waals
'1029 L191 5.40x40 TM5 Van der Waals
'1029 W194 5.43x43 TM5 hydrophobic
'1029 W194 5.43x43 TM5 Van der Waals
'1029 M265 6.55x55 TM6 Van der Waals
'1029 F281 7.35x34 TM7 hydrophobic
'1029 F281 7.35x34 TM7 Van der Waals

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Snake plot — Download: PNG | SVG
ICL1 H Q L R R ICL1ECL1 F H G V D ECL1ICL2 P P S Y K A L L ICL2ECL2 W T C C P R P C S E L F P L I ECL2ICL3 H Q D R Q V P G M A R M ICL3ECL3 T L ECL3N-term M E E C W V T E I A N G S K D G L D S N P M K D Y M I L N-termC-term C V R G L G S E A K E E A P R S S V T E T E A D G K I T P W P D S R D L D L S D C C-term S G P Q K T A V A V L C T L L G L L S A L E N V A V L Y L I L S S K P S Y L F I G S L A G A D F L A S V V F A C S F V N F H V S K A V F L L K I G S V T M T F T A S V G S L L L T A I D R Y L C L R Y T R G R A L V T L G I M W V L S A L V S Y L P L M G P N D Y L L S W L L F I A F L F S G I I Y T Y G H V L W K A H Q H V A S L S G R L D V R L A K T L G L V L A V L L I C W F P V L A L M A H S L A T S D Q V K K A F A F C S M L C L I N S M V N P V I Y A L R S G E A H H W K K I R S S C L A H
Helix box plot — Download: PNG | SVG V N E L A S L L G L L T C L V A V A T K 1 G S L A G A D F L A S V V F A C S F V N 2 L L L S G V S A T F T M T V S G I K L L 3 A L V T L G I M W V L S A L V S Y L P L 4 Y T Y I I G S F L F A I F L L W S L L Y 5 G L V L A V L L I C W F P V L A L M A H 6 V P N V M S N I L C L M S C F A F A K 7

GPCRdb(A)
GPCRdb(A)
CB2 receptor
TM2
2x57 2.57x57 F87
2x61 2.61x61 F91
2x64 2.64x64 F94
TM3
3x32 3.32x32 V113
3x33 3.33x33 T114
TM5
5x39 5.39x39 Y190
5x40 5.40x40 L191
5x43 5.43x43 W194
TM6
6x55 6.55x55 M265
TM7
7x34 7.35x34 F281