PDB
20ZD
Resolution
2.8 Å
Released
June 3, 2026
Receptor
NTS1
Class
A
Species
Homo sapiens
Ligand
Function
JMV449
Agonist
Reference
10.1038/S41586-026-10228-W

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Ligand Amino Acid Generic Number Segment Interaction Type
JMV449 F127 2.65x64 TM2 Van der Waals
JMV449 Y145 3.29x29 TM3 polar (hydrogen bond)
JMV449 Y145 3.29x29 TM3 hydrophobic
JMV449 M203 4.60x61 TM4 hydrophobic
JMV449 T225 45.51x51 ECL2 Van der Waals
JMV449 P226 45.52x52 ECL2 hydrophobic
JMV449 I237 5.39x40 TM5 hydrophobic
JMV449 F326 6.58x58 TM6 hydrophobic
JMV449 D331 ECL3 hydrophobic
JMV449 W334 ECL3 hydrophobic
JMV449 Y339 7.28x27 TM7 aromatic (pi-cation)
JMV449 Y339 7.28x27 TM7 hydrophobic
JMV449 Y342 7.31x30 TM7 hydrophobic
JMV449 H343 7.32x31 TM7 Van der Waals

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Snake plot — Download: PNG | SVG
ICL1 K S L Q ICL1ECL1 H H P W A F ECL1ICL2 P F K A K T L M ICL2ECL2 G E Q N R S A D G Q H A G G L V C T P T I ECL2ICL3 Q V C T V G G E H S T F S M A I E ICL3ECL3 S D E Q W ECL3N-term M R L N S S A P G T P G T P A A D P F Q R A Q A G L E E A L L A P G F G N A S G N A S E R V L A A P S S E L D V N T N-termC-term P V W R R R R K R P A F S R K A D S V S S N H T L S S N A T R E T L Y C-term D I Y S K V L V T A V Y L A L F V V G T V G N T V T A F T L A R K S L Q S T V H Y H L G S L A L S D L L T L L L A M P V E L Y N F I W V G D A G C R G Y Y F L R D A C T Y A T A L N V A S L S V E R Y L A I C H S R S R T K K F I S A I W L A S A L L A V P M L F T M H T A T V K V V I Q V N T F M S F I F P M V V I S V L N T I I A N K L T V M V R Q A A E Q G P G R V Q A L R H G V R V L R A V V I A F V V C W L P Y H V R R L M F C Y I T P F L Y D F Y H Y F Y M V T N A L F Y V S S T I N P I L Y N L V S A N F L A L C F R H I T L A C
Helix box plot — Download: PNG | SVG T N G V T G V V F L A L Y V A T V L V K 1 G S L A L S D L L T L L L A M P V E L Y N 2 S A V N L A T A Y T C A D R L F Y Y G R 3 T K K F I S A I W L A S A L L A V P M 4 N L V S I V V M P F I F S M F T N V Q I V 5 R A V V I A F V V C W L P Y H V R R L M 6 I P N I T S S V Y F L A N T V M Y F Y 7

GPCRdb(A)
GPCRdb(A)
NTS1 receptor
TM2
2x64 2.65x64 F127
TM3
3x29 3.29x29 Y145
TM4
4x61 4.60x61 M203
ECL2
45x51 45.51x51 T225
45x52 45.52x52 P226
TM5
5x40 5.39x40 I237
TM6
6x58 6.58x58 F326
TM7
7x27 7.28x27 Y339
7x30 7.31x30 Y342
7x31 7.32x31 H343