PDB
22EM
Resolution
2.9 Å
Released
May 6, 2026
Receptor
κ
Class
A
Species
Homo sapiens
Ligand
beta01
Function
Agonist
Reference
—

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Ligand Amino Acid Generic Number Segment Interaction Type
beta01 Q115 2.60x60 TM2 polar (hydrogen bond)
beta01 Q115 2.60x60 TM2 Van der Waals
beta01 V118 2.63x63 TM2 Van der Waals
beta01 V118 2.63x63 TM2 hydrophobic
beta01 N122 2.67x67 TM2 Van der Waals
beta01 N122 2.67x67 TM2 polar (hydrogen bond with backbone)
beta01 S123 23.49x49 ECL1 Van der Waals
beta01 W124 23.50x50 ECL1 Van der Waals
beta01 W124 23.50x50 ECL1 hydrophobic
beta01 V134 3.28x28 TM3 Van der Waals
beta01 V134 3.28x28 TM3 hydrophobic
beta01 I135 3.29x29 TM3 hydrophobic
beta01 I135 3.29x29 TM3 Van der Waals
beta01 D138 3.32x32 TM3 polar (charge-assisted hydrogen bond)
beta01 Y139 3.33x33 TM3 hydrophobic
beta01 Y139 3.33x33 TM3 Van der Waals
beta01 M142 3.36x36 TM3 Van der Waals
beta01 E209 ECL2 polar (charge-assisted hydrogen bond)
beta01 C210 45.50x50 ECL2 Van der Waals
beta01 C210 45.50x50 ECL2 polar (hydrogen bond with backbone)
beta01 S211 45.51x51 ECL2 polar (hydrogen bond)
beta01 Y219 5.31x32 TM5 polar (hydrogen bond)
beta01 I290 6.51x51 TM6 Van der Waals
beta01 I290 6.51x51 TM6 hydrophobic
beta01 H304 ECL3 Van der Waals
beta01 I316 7.39x38 TM7 hydrophobic
beta01 I316 7.39x38 TM7 Van der Waals
beta01 Y320 7.43x42 TM7 polar (hydrogen bond)

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Snake plot — Download: PNG | SVG
ICL1 T K M K ICL1ECL1 S W P F ECL1ICL2 P V K A L D F R ICL2ECL2 G T K V R E D V D V I E C S L Q F P D D ECL2ICL3 R L L S G ICL3ECL3 S T S H ECL3N-term M D S P I Q I F R G E P G P T C A P S A C L P P N S S A W F P G W A E P D S N G S A G S E D A Q L E P A H I S P N-termC-term P L K M R M E R Q S T S R V R N T V Q D P A Y L R D I D G M N K P V C-term A I P V I I T A V Y S V V F V V G L V G N S L V M F V I I R Y T A T N I Y I F N L A L A D A L V T T T M P F Q S T V Y L M N G D V L C K I V I S I D Y Y N M F T S I F T L T M M S V D R Y I A V C H T P L K A K I I N I C I W L L S S S V G I S A I V L G D Y S W W D L F M K I C V F I F A F V I P V L I I I V C Y T L M I L R L K S V S R E K D R N L R R I T R L V L V V V A V F V V C W T P I H I F I L V E A L G S T A A L S S Y Y F C I A L G Y T N S S L N P I L Y A F L D E N F R D F K R C F C F
Helix box plot — Download: PNG | SVG S N G V L G V V F V V S Y V A T I I V P 1 F N L A L A D A L V T T T M P F Q S T V 2 M T L T F I S T F M N Y Y D I S I V I K 3 A K I I N I C I W L L S S S V G I S A I 4 Y C V I I I L V P I V F A F I F V C I K M 5 L V V V A V F V V C W T P I H I F I L V 6 I P N L S S N T Y G L A I C F Y Y S S 7

GPCRdb(A)
GPCRdb(A)
κ receptor
TM2
2x60 2.60x60 Q115
2x63 2.63x63 V118
2x67 2.67x67 N122
ECL1
23x49 23.49x49 S123
23x50 23.50x50 W124
TM3
3x28 3.28x28 V134
3x29 3.29x29 I135
3x32 3.32x32 D138
3x33 3.33x33 Y139
3x36 3.36x36 M142
ECL2
45x50 45.50x50 C210
45x51 45.51x51 S211
TM5
5x32 5.31x32 Y219
TM6
6x51 6.51x51 I290
TM7
7x38 7.39x38 I316
7x42 7.43x42 Y320