PDB
22ES
Resolution
2.4 Å
Released
May 6, 2026
Receptor
κ
Class
A
Species
Homo sapiens
Ligand
difelikefalin
Function
Agonist
Reference
—

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Ligand Amino Acid Generic Number Segment Interaction Type
difelikefalin Q115 2.60x60 TM2 polar (hydrogen bond)
difelikefalin V118 2.63x63 TM2 Van der Waals
difelikefalin N122 ECL1 polar (hydrogen bond with backbone)
difelikefalin N122 ECL1 polar (hydrogen bond)
difelikefalin N122 ECL1 polar (hydrogen bond)
difelikefalin W124 23.50x50 ECL1 Van der Waals
difelikefalin W124 23.50x50 ECL1 hydrophobic
difelikefalin V134 3.28x28 TM3 hydrophobic
difelikefalin V134 3.28x28 TM3 Van der Waals
difelikefalin I135 3.29x29 TM3 Van der Waals
difelikefalin I135 3.29x29 TM3 hydrophobic
difelikefalin D138 3.32x32 TM3 polar (charge-assisted hydrogen bond)
difelikefalin Y139 3.33x33 TM3 Van der Waals
difelikefalin Y139 3.33x33 TM3 hydrophobic
difelikefalin M142 3.36x36 TM3 Van der Waals
difelikefalin M142 3.36x36 TM3 hydrophobic
difelikefalin V207 ECL2 hydrophobic
difelikefalin V207 ECL2 Van der Waals
difelikefalin I208 ECL2 Van der Waals
difelikefalin E209 ECL2 Van der Waals
difelikefalin C210 45.50x50 ECL2 Van der Waals
difelikefalin C210 45.50x50 ECL2 polar (hydrogen bond with backbone)
difelikefalin S211 45.51x51 ECL2 Van der Waals
difelikefalin W287 6.48x48 TM6 hydrophobic
difelikefalin W287 6.48x48 TM6 Van der Waals
difelikefalin I316 7.39x38 TM7 hydrophobic
difelikefalin I316 7.39x38 TM7 Van der Waals
difelikefalin G319 7.42x41 TM7 Van der Waals
difelikefalin Y320 7.43x42 TM7 polar (hydrogen bond)
difelikefalin Y320 7.43x42 TM7 Van der Waals

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Snake plot — Download: PNG | SVG
ICL1 T K M K ICL1ECL1 S W P F ECL1ICL2 P V K A L D F R ICL2ECL2 G T K V R E D V D V I E C S L Q F P D D ECL2ICL3 R L L S G ICL3ECL3 S T S H ECL3N-term M D S P I Q I F R G E P G P T C A P S A C L P P N S S A W F P G W A E P D S N G S A G S E D A Q L E P A H I S P N-termC-term P L K M R M E R Q S T S R V R N T V Q D P A Y L R D I D G M N K P V C-term A I P V I I T A V Y S V V F V V G L V G N S L V M F V I I R Y T A T N I Y I F N L A L A D A L V T T T M P F Q S T V Y L M N G D V L C K I V I S I D Y Y N M F T S I F T L T M M S V D R Y I A V C H T P L K A K I I N I C I W L L S S S V G I S A I V L G D Y S W W D L F M K I C V F I F A F V I P V L I I I V C Y T L M I L R L K S V S R E K D R N L R R I T R L V L V V V A V F V V C W T P I H I F I L V E A L G S T A A L S S Y Y F C I A L G Y T N S S L N P I L Y A F L D E N F R D F K R C F C F
Helix box plot — Download: PNG | SVG S N G V L G V V F V V S Y V A T I I V P 1 F N L A L A D A L V T T T M P F Q S T V 2 M T L T F I S T F M N Y Y D I S I V I K 3 A K I I N I C I W L L S S S V G I S A I 4 Y C V I I I L V P I V F A F I F V C I K M 5 L V V V A V F V V C W T P I H I F I L V 6 I P N L S S N T Y G L A I C F Y Y S S 7

GPCRdb(A)
GPCRdb(A)
κ receptor
TM2
2x60 2.60x60 Q115
2x63 2.63x63 V118
ECL1
23x50 23.50x50 W124
TM3
3x28 3.28x28 V134
3x29 3.29x29 I135
3x32 3.32x32 D138
3x33 3.33x33 Y139
3x36 3.36x36 M142
ECL2
45x50 45.50x50 C210
45x51 45.51x51 S211
TM6
6x48 6.48x48 W287
TM7
7x38 7.39x38 I316
7x41 7.42x41 G319
7x42 7.43x42 Y320