PDB
23OI
Resolution
2.7 Å
Released
July 1, 2026
Receptor
NOP
Class
A
Species
Homo sapiens
Ligand
cebranopadol
Function
Agonist
Reference
—

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Ligand Amino Acid Generic Number Segment Interaction Type
cebranopadol Q107 2.60x60 TM2 polar (hydrogen bond)
cebranopadol W116 23.50x50 ECL1 Van der Waals
cebranopadol V126 3.28x28 TM3 Van der Waals
cebranopadol I127 3.29x29 TM3 hydrophobic
cebranopadol I127 3.29x29 TM3 Van der Waals
cebranopadol D130 3.32x32 TM3 polar (charge-assisted hydrogen bond)
cebranopadol Y131 3.33x33 TM3 Van der Waals
cebranopadol Y131 3.33x33 TM3 hydrophobic
cebranopadol M134 3.36x36 TM3 hydrophobic
cebranopadol M134 3.36x36 TM3 Van der Waals
cebranopadol C200 45.50x50 ECL2 Van der Waals
cebranopadol I219 5.42x43 TM5 hydrophobic
cebranopadol W276 6.48x48 TM6 hydrophobic
cebranopadol W276 6.48x48 TM6 Van der Waals
cebranopadol V279 6.51x51 TM6 hydrophobic
cebranopadol Q280 6.52x52 TM6 Van der Waals
cebranopadol V283 6.55x55 TM6 hydrophobic
cebranopadol V283 6.55x55 TM6 Van der Waals
cebranopadol Y309 7.43x42 TM7 Van der Waals

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Snake plot — Download: PNG | SVG
ICL1 T K M K ICL1ECL1 F W P F ECL1ICL2 P I R A L D V R ICL2ECL2 S A Q V E D E E I E C L V E I P T ECL2ICL3 R L L S G ICL3ECL3 V Q P S ECL3N-term M E P L F P A P F W E V I Y G S H L Q G N L S L L S P N H S L L P P H L L L N A S H G A F L P N-termC-term A S A L R R D V Q V S D R V R S I A K D V A L A C K T S E T V P R P A C-term L G L K V T I V G L Y L A V C V G G L L G N C L V M Y V I L R H T A T N I Y I F N L A L A D T L V L L T L P F Q G T D I L L G G N A L C K T V I A I D Y Y N M F T S T F T L T A M S V D R Y V A I C H T S S K A Q A V N V A I W A L A S V V G V P V A I M G P Q D Y W G P V F A I C I F L F S F I V P V L V I S V C Y S L M I R R L R G V S R E K D R N L R R I T R L V L V V V A V F V G C W T P V Q V F V L A Q G L G S E T A V A I L R F C T A L G Y V N S C L N P I L Y A F L D E N F R K F K A C F C C
Helix box plot — Download: PNG | SVG C N G L L G G V C V A L Y L G V I T V K 1 F N L A L A D T L V L L T L P F Q G T D 2 A T L T F T S T F M N Y Y D I A I V T K 3 A Q A V N V A I W A L A S V V G V P V A 4 Y C V S I V L V P V I F S F L F I C I A F 5 L V V V A V F V G C W T P V Q V F V L A 6 I P N L C S N V Y G L A T C F R L I A 7

GPCRdb(A)
GPCRdb(A)
NOP receptor
TM2
2x60 2.60x60 Q107
ECL1
23x50 23.50x50 W116
TM3
3x28 3.28x28 V126
3x29 3.29x29 I127
3x32 3.32x32 D130
3x33 3.33x33 Y131
3x36 3.36x36 M134
ECL2
45x50 45.50x50 C200
TM5
5x43 5.42x43 I219
TM6
6x48 6.48x48 W276
6x51 6.51x51 V279
6x52 6.52x52 Q280
6x55 6.55x55 V283
TM7
7x42 7.43x42 Y309