PDB
23SO
Resolution
3.0 Å
Released
July 1, 2026
Receptor
μ
Class
A
Species
Homo sapiens
Ligand
cebranopadol
Function
Agonist
Reference
—

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Ligand Amino Acid Generic Number Segment Interaction Type
cebranopadol Q126 2.60x60 TM2 polar (hydrogen bond)
cebranopadol N129 2.63x63 TM2 Van der Waals
cebranopadol N129 2.63x63 TM2 polar (hydrogen bond)
cebranopadol W135 23.50x50 ECL1 hydrophobic
cebranopadol W135 23.50x50 ECL1 Van der Waals
cebranopadol V145 3.28x28 TM3 Van der Waals
cebranopadol D149 3.32x32 TM3 polar (charge-assisted hydrogen bond)
cebranopadol Y150 3.33x33 TM3 hydrophobic
cebranopadol Y150 3.33x33 TM3 Van der Waals
cebranopadol M153 3.36x36 TM3 Van der Waals
cebranopadol W295 6.48x48 TM6 hydrophobic
cebranopadol I298 6.51x51 TM6 hydrophobic
cebranopadol I298 6.51x51 TM6 Van der Waals
cebranopadol H299 6.52x52 TM6 aromatic (face-to-edge)
cebranopadol H299 6.52x52 TM6 Van der Waals
cebranopadol W320 7.35x34 TM7 hydrophobic
cebranopadol W320 7.35x34 TM7 Van der Waals
cebranopadol I324 7.39x38 TM7 hydrophobic
cebranopadol Y328 7.43x42 TM7 hydrophobic
cebranopadol Y328 7.43x42 TM7 Van der Waals

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Snake plot — Download: PNG | SVG
ICL1 T K M K ICL1ECL1 T W P F ECL1ICL2 P V K A L D F R ICL2ECL2 T T K Y R Q G S I D C T L T F S H ECL2ICL3 R M L S G ICL3ECL3 T I P E ECL3N-term M D S S A A P T N A S N C T D A L A Y S S C S P A P S P G S W V N L S H L D G N L S D P C G P N R T D L G G R D S L C P P T G S P S N-termC-term P T S S N I E Q Q N S T R I R Q N T R D H P S T A N T V D R T N H Q L E N L E A E T A P L P C-term M I T A I T I M A L Y S I V C V V G L F G N F L V M Y V I V R Y T A T N I Y I F N L A L A D A L A T S T L P F Q S V N Y L M G G T I L C K I V I S I D Y Y N M F T S I F T L C T M S V D R Y I A V C H T P R N A K I I N V C N W I L S S A I G L P V M F M A P T W Y W E N L L K I C V F I F A F I M P V L I I T V C Y G L M I L R L K S V S K E K D R N L R R I T R M V L V V V A V F I V C W T P I H I Y V I I K A L V T T F Q T V S W H F C I A L G Y T N S C L N P V L Y A F L D E N F R E F K R C F C I
Helix box plot — Download: PNG | SVG F N G F L G V V C V I S Y L A M I T I A 1 F N L A L A D A L A T S T L P F Q S V N 2 T C L T F I S T F M N Y Y D I S I V I K 3 A K I I N V C N W I L S S A I G L P V M 4 Y C V T I I L V P M I F A F I F V C I K L 5 L V V V A V F I V C W T P I H I Y V I I 6 V P N L C S N T Y G L A I C F H W S V 7

GPCRdb(A)
GPCRdb(A)
μ receptor
TM2
2x60 2.60x60 Q126
2x63 2.63x63 N129
ECL1
23x50 23.50x50 W135
TM3
3x28 3.28x28 V145
3x32 3.32x32 D149
3x33 3.33x33 Y150
3x36 3.36x36 M153
TM6
6x48 6.48x48 W295
6x51 6.51x51 I298
6x52 6.52x52 H299
TM7
7x34 7.35x34 W320
7x38 7.39x38 I324
7x42 7.43x42 Y328