PDB
24XZ
Resolution
2.9 Å
Released
June 10, 2026
Receptor
P2Y14
Class
A
Species
Homo sapiens
Ligand
UDP
Function
Agonist
Reference
10.1016/J.BBRC.2026.153976

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Ligand Amino Acid Generic Number Segment Interaction Type
UDP C94 3.25x25 TM3 polar (hydrogen bond with backbone)
UDP C94 3.25x25 TM3 Van der Waals
UDP A98 3.29x29 TM3 Van der Waals
UDP V99 3.30x30 TM3 Van der Waals
UDP Y102 3.33x33 TM3 polar (hydrogen bond)
UDP N156 4.60x60 TM4 polar (hydrogen bond)
UDP C172 45.50x50 ECL2 Van der Waals
UDP K176 ECL2 polar (charge-assisted hydrogen bond)
UDP H184 5.36x36 TM5 Van der Waals
UDP N188 5.40x40 TM5 polar (hydrogen bond)
UDP N188 5.40x40 TM5 Van der Waals
UDP F191 5.43x43 TM5 Van der Waals
UDP R253 6.55x55 TM6 polar (charge-assisted hydrogen bond)
UDP Y256 6.58x58 TM6 polar (hydrogen bond)
UDP Y256 6.58x58 TM6 Van der Waals
UDP Q260 6.62x62 TM6 polar (hydrogen bond)
UDP Q260 6.62x62 TM6 Van der Waals
UDP R274 7.32x31 TM7 polar (charge-assisted hydrogen bond)
UDP K277 7.35x34 TM7 polar (charge-assisted hydrogen bond)

UDP

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Snake plot — Download: PNG | SVG
ICL1 P S S ICL1ECL1 L G P ECL1ICL2 P L W T S F I Q ICL2ECL2 N Q S V R E V T Q I K C I E L K S ECL2ICL3 L K S ICL3ECL3 A H Y ECL3N-term M I N S T S T Q P P D E S C S Q N N-termC-term L H I P L K A Q N D L D I S R I K R G N T T L E S T D T L C-term L L I T Q Q I I P V L Y C M V F I A G I L L N G V S G W I F F Y V K S F I I Y L K N I V I A D F V M S L T F P F K I L G D S G W Q L N V F V C R V S A V L F Y V N M Y V S I V F F G L I S F D R Y Y K I V K S V S Y S K L L S V I V W M L M L L L A V P N I I L T E L G R K W H K A S N Y I F V A I F W I V F L L L I V F Y T A I T K K I F K S H S R N S T S V K K K S S R N I F S I V F V F F V C F V P Y H I A R I P Y T K S Q T E S C Q S K E I L R Y M K E F T L L L S A A N V C L D P I I Y F F L C Q P L C K F R E I K
Helix box plot — Download: PNG | SVG G N L L I G A I F V M C Y L V P I I Q Q 1 K N I V I A D F V M S L T F P F K I L G 2 L G F F V I S V Y M N V Y F L V A S V R 3 S K L L S V I V W M L M L L L A V P N I 4 Y F V I L L L F V I W F I A V F I Y N S 5 I F S I V F V F V F C F V P Y H I A R I P 6 I P D L C V N A A S L L L T F E K M Y 7

GPCRdb(A)
GPCRdb(A)
P2Y14 receptor
TM3
3x25 3.25x25 C94
3x29 3.29x29 A98
3x30 3.30x30 V99
3x33 3.33x33 Y102
TM4
4x60 4.60x60 N156
ECL2
45x50 45.50x50 C172
TM5
5x36 5.36x36 H184
5x40 5.40x40 N188
5x43 5.43x43 F191
TM6
6x55 6.55x55 R253
6x58 6.58x58 Y256
6x62 6.62x62 Q260
TM7
7x31 7.32x31 R274
7x34 7.35x34 K277