PDB
25NV
Resolution
3.2 Å
Released
June 3, 2026
Receptor
PTH1
Class
B1
Species
Homo sapiens
Ligand
SPT
Function
Agonist
Reference
—

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Ligand Amino Acid Generic Number Segment Interaction Type
SPT M32 N-term polar (hydrogen bond with backbone)
SPT M32 N-term Van der Waals
SPT T33 N-term Van der Waals
SPT K34 N-term Van der Waals
SPT Q37 N-term Van der Waals
SPT I38 N-term hydrophobic
SPT I38 N-term Van der Waals
SPT D113 N-term Van der Waals
SPT I115 N-term hydrophobic
SPT I135 N-term hydrophobic
SPT I135 N-term Van der Waals
SPT Y136 N-term hydrophobic
SPT Y136 N-term Van der Waals
SPT D137 N-term polar (charge-assisted hydrogen bond)
SPT F138 N-term Van der Waals
SPT F138 N-term hydrophobic
SPT A165 N-term polar (hydrogen bond with backbone)
SPT A165 N-term Van der Waals
SPT N166 N-term Van der Waals
SPT Y167 N-term polar (hydrogen bond with backbone)
SPT Y167 N-term Van der Waals
SPT L174 1.26x26 TM1 Van der Waals
SPT L174 1.26x26 TM1 hydrophobic
SPT T175 1.27x27 TM1 Van der Waals
SPT T175 1.27x27 TM1 polar (hydrogen bond with backbone)
SPT N176 1.28x28 TM1 Van der Waals
SPT E180 1.32x32 TM1 polar (charge-assisted hydrogen bond)
SPT F184 1.36x36 TM1 Van der Waals
SPT F184 1.36x36 TM1 hydrophobic
SPT L187 1.39x39 TM1 Van der Waals
SPT L187 1.39x39 TM1 hydrophobic
SPT Y195 1.47x47 TM1 polar (hydrogen bond)
SPT Y195 1.47x47 TM1 Van der Waals
SPT R233 2.60x60 TM2 polar (charge-assisted hydrogen bond)
SPT Y245 ECL1 hydrophobic
SPT Y245 ECL1 Van der Waals
SPT F288 3.36x36 TM3 hydrophobic
SPT F288 3.36x36 TM3 Van der Waals
SPT L289 3.37x37 TM3 Van der Waals
SPT L289 3.37x37 TM3 hydrophobic
SPT L292 3.40x40 TM3 hydrophobic
SPT L292 3.40x40 TM3 Van der Waals
SPT D353 45.52x52 ECL2 polar (charge-assisted hydrogen bond)
SPT L354 ECL2 Van der Waals
SPT L354 ECL2 hydrophobic
SPT S355 ECL2 Van der Waals
SPT K360 5.36x37 TM5 Van der Waals
SPT W361 5.37x38 TM5 hydrophobic
SPT W361 5.37x38 TM5 Van der Waals
SPT Q364 5.40x40 TM5 Van der Waals
SPT I367 5.43x43 TM5 Van der Waals
SPT I367 5.43x43 TM5 hydrophobic
SPT T427 ECL3 Van der Waals
SPT T427 ECL3 polar (hydrogen bond with backbone)
SPT Y429 ECL3 hydrophobic
SPT Y429 ECL3 Van der Waals
SPT W437 7.35x34 TM7 polar (hydrogen bond)
SPT W437 7.35x34 TM7 Van der Waals
SPT M441 7.39x38 TM7 hydrophobic
SPT M441 7.39x38 TM7 Van der Waals
SPT E444 7.42x41 TM7 Van der Waals
SPT M445 7.43x42 TM7 Van der Waals
SPT N448 7.46x45 TM7 polar (hydrogen bond)
SPT N448 7.46x45 TM7 Van der Waals

SPT

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Snake plot — Download: PNG | SVG
ICL1 R R L H ICL1ECL1 L D E A E R L T E E E L R A I A Q A P P P P A T A A A ECL1ICL2 A F F ICL2ECL2 N T G C W D L S S ECL2ICL3 R E T N A G R C ICL3ECL3 P Y T E V S ECL3N-term M G T A R I A P G L A L L L C C P V L S S A Y A L V D A D D V M T K E E Q I F L L H R A Q A Q C E K R L K E V L Q R P A S I M E S D K G W T S A S T S G K P R K D K A S G K L Y P E S E E D K E A P T G S R Y R G R P C L P E W D H I L C W P L G A P G E V V A V P C P D Y I Y D F N H K G H A Y R R C D R N G S W E L V P G H N R T W A N Y S E C V K N-termC-term S G S S S Y S Y G P M V S H T S V T N V G P R V G L G L P L S P R L L P T A T T N G H P Q L P G H A K P G T P A L E T L E T T P P A M A A P K D D G F L N G S C S G L D E E A S G P E R P P A L L Q E E W E T V M C-term F L T N E T R E R E V F D R L G M I Y T V G Y S V S L A S L T V A V L I L A Y F C T R N Y I H M H L F L S F M L R A V S I F V K D A V L Y S G A T G Y A G C R V A V T F F L Y F L A T N Y Y W I L V E G L Y L H S L I F M S E K K Y L W G F T V F G W G L P A V F V A V W V S V R A T L A G N K K W I I Q V P I L A S I V L N F I L F I N I V R V L A T K L D T R Q Q Y R K L L K S T L V L M P L F G V H Y I V F M A T G T L W Q V Q M H Y E M L F N S F Q G F F V A I I Y C F C N G E I K K W T L K R K V Q A E S W S R A L D F A R
Helix box plot — Download: PNG | SVG T L S A L S V S Y G V T Y I M G L R D F 1 M H L F L S F M L R A V S I F V K D A V 2 V L I W Y Y N T A L F Y L F F T V A V R 3 Y L W G F T V G F W G L P A V F V A V W V 4 F L I F N L V I S A L I P V Q I I W K K N 5 L V L M P L F G V H Y I V F M A T 6 I A V F F G Q F S N F L M E Y H M Q V 7

GPCRdb(A)
GPCRdb(B)
PTH1 receptor
TM1
1x22 1.26x26 L174
1x23 1.27x27 T175
1x24 1.28x28 N176
1x28 1.32x32 E180
1x32 1.36x36 F184
1x35 1.39x39 L187
1x43 1.47x47 Y195
TM2
2x53 2.60x60 R233
TM3
3x32 3.36x36 F288
3x33 3.37x37 L289
3x36 3.40x40 L292
ECL2
45x52 45.52x52 D353
TM5
5x41 5.36x37 K360
5x42 5.37x38 W361
5x44 5.40x40 Q364
5x47 5.43x43 I367
TM7
7x30 7.35x34 W437
7x34 7.39x38 M441
7x37 7.42x41 E444
7x38 7.43x42 M445
7x41 7.46x45 N448