Structure information

β2-adrenoceptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

3PDS

SPECIES

Homo sapiens

RESOLUTION

3.500

PREFERRED CHAIN

A

REFERENCE

10.1038/NATURE09665

PUBLICATION DATE

Jan. 12, 2011

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
FAUC50 C93 2.64x63 TM2 polar (hydrogen bond)
FAUC50 W99 23.50x50 ECL1 Van der Waals
FAUC50 W109 3.28x28 TM3 Van der Waals
FAUC50 W109 3.28x28 TM3 hydrophobic
FAUC50 D113 3.32x32 TM3 polar (charge-assisted hydrogen bond)
FAUC50 V114 3.33x33 TM3 Van der Waals
FAUC50 V114 3.33x33 TM3 hydrophobic
FAUC50 C191 45.50x50 ECL2 Van der Waals
FAUC50 C191 45.50x50 ECL2 hydrophobic
FAUC50 D192 45.51x51 ECL2 Van der Waals
FAUC50 F193 45.52x52 ECL2 Van der Waals
FAUC50 F193 45.52x52 ECL2 aromatic (edge-to-face)
FAUC50 A200 5.39x40 TM5 Van der Waals
FAUC50 S203 5.42x43 TM5 polar (hydrogen bond)
FAUC50 S203 5.42x43 TM5 polar (hydrogen bond with backbone)
FAUC50 S203 5.42x43 TM5 polar (hydrogen bond)
FAUC50 S207 5.46x461 TM5 polar (hydrogen bond)
FAUC50 S207 5.46x461 TM5 Van der Waals
FAUC50 W286 6.48x48 TM6 Van der Waals
FAUC50 F289 6.51x51 TM6 Van der Waals
FAUC50 F289 6.51x51 TM6 aromatic (edge-to-face)
FAUC50 F290 6.52x52 TM6 Van der Waals
FAUC50 F290 6.52x52 TM6 hydrophobic
FAUC50 N293 6.55x55 TM6 Van der Waals
FAUC50 N293 6.55x55 TM6 polar (hydrogen bond)
FAUC50 Y308 7.35x34 TM7 Van der Waals
FAUC50 I309 7.36x35 TM7 hydrophobic
FAUC50 I309 7.36x35 TM7 Van der Waals
FAUC50 N312 7.39x38 TM7 polar (hydrogen bond)
FAUC50 N312 7.39x38 TM7 polar (hydrogen bond)
FAUC50 W313 7.40x39 TM7 hydrophobic
FAUC50 W313 7.40x39 TM7 Van der Waals
FAUC50 Y316 7.43x42 TM7 Van der Waals

Ligands

FAUC50

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Residue Diagrams

V N G F V I A L V I L S M V I G M G V V 1 T S L A C A D L V M G A L V V P F G A A H 2 V C L T E I S A T V C L V D I S T W F E 3 A R V I I L M V W I V S G L T S F L P I 4 Y V F V M I V L P V Y F S V I S S A I A Y 5 G I I M G T F T L C W L P F F I V N I V 6 L P N F G S N V Y G I W N L L I Y V E 7
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ICL1 E R L Q ICL1ECL1 M W T F ECL1ICL2 P F K Y Q S L L ICL2ECL2 W Y R A T H Q E A I N C Y A N E T C C D F F T ECL2ICL3 G R F H V Q N L S Q V E Q D G R T G H G L R R S ICL3ECL3 D N L I ECL3N-term M G Q P G N G S A F L L A P N G S H A P D H D V T N-termC-term L R R S S L K A Y G N G Y S S N G N T G E Q S G Y H V E Q E K E N K L L C E D L P G T E D F V G H Q G T V P S D N I D S Q G R N C S T N D S L L C-term Q E R D E V W V V G M G I V M S L I V L A I V F G N V L V I T A I A K F T V T N Y F I T S L A C A D L V M G L A V V P F G A A H I L M K G N F W C E F W T S I D V L C V T A S I E T L C V I A V D R Y F A I T S T K N K A R V I I L M V W I V S G L T S F L P I Q M H N Q A Y A I A S S I V S F Y V P L V I M V F V Y S R V F Q E A K R Q L Q K I D K S E S K F C L K E H K A L K T L G I I M G T F T L C W L P F F I V N I V H V I Q R K E V Y I L L N W I G Y V N S G F N P L I Y C R S P D F Q E F R I A L L C
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Residue Table


GPCRdb(A)
GPCRdb(A)
β2-adrenoceptor
TM2
2x63 2.64x63 H93
ECL1
23x50 23.50x50 W99
TM3
3x28 3.28x28 W109
3x32 3.32x32 D113
3x33 3.33x33 V114
ECL2
45x50 45.50x50 C191
45x51 45.51x51 D192
45x52 45.52x52 F193
TM5
5x40 5.39x40 A200
5x43 5.42x43 S203
5x461 5.46x461 S207
TM6
6x48 6.48x48 W286
6x51 6.51x51 F289
6x52 6.52x52 F290
6x55 6.55x55 N293
TM7
7x34 7.35x34 Y308
7x35 7.36x35 I309
7x38 7.39x38 N312
7x39 7.40x39 W313
7x42 7.43x42 Y316