PDB
4BV0
Resolution
3.1 Å
Released
Jan. 29, 2014
Receptor
NTS1
Class
A
Species
Rattus norvegicus
Ligand
Function
Neurotensin
Agonist
Reference
10.1073/PNAS.1317903111

NGL is a WebGL based 3D viewer powered by MMTF.

Download PDB file
Download list in excel
Ligand Amino Acid Generic Number Segment Interaction Type
Neurotensin D54 N-term polar (charge-charge)
Neurotensin L55 N-term polar (hydrogen bond with backbone)
Neurotensin L55 N-term hydrophobic
Neurotensin D56 N-term polar (hydrogen bond with backbone)
Neurotensin F128 2.65x64 TM2 hydrophobic
Neurotensin H132 ECL1 Van der Waals
Neurotensin H133 ECL1 Van der Waals
Neurotensin Y146 3.29x29 TM3 polar (hydrogen bond)
Neurotensin L213 ECL2 hydrophobic
Neurotensin V224 ECL2 hydrophobic
Neurotensin C225 45.50x50 ECL2 Van der Waals
Neurotensin T226 45.51x51 ECL2 Van der Waals
Neurotensin P227 45.52x52 ECL2 Van der Waals
Neurotensin L234 5.35x36 TM5 Van der Waals
Neurotensin I238 5.39x40 TM5 Van der Waals
Neurotensin R327 6.54x54 TM6 polar (hydrogen bond)
Neurotensin R327 6.54x54 TM6 polar (charge-charge)
Neurotensin R328 6.55x55 TM6 Van der Waals
Neurotensin F331 6.58x58 TM6 aromatic (pi-cation)
Neurotensin F331 6.58x58 TM6 hydrophobic
Neurotensin V332 6.59x59 TM6 polar (hydrogen bond with backbone)
Neurotensin I334 ECL3 polar (hydrogen bond with backbone)
Neurotensin S335 ECL3 Van der Waals
Neurotensin D336 ECL3 polar (hydrogen bond)
Neurotensin D336 ECL3 polar (charge-charge)
Neurotensin D336 ECL3 Van der Waals
Neurotensin W339 ECL3 Van der Waals
Neurotensin W339 ECL3 hydrophobic
Neurotensin T341 7.25x24 TM7 Van der Waals
Neurotensin F344 7.28x27 TM7 hydrophobic
Neurotensin F344 7.28x27 TM7 aromatic (pi-cation)
Neurotensin Y347 7.31x30 TM7 polar (hydrogen bond)
Neurotensin Y347 7.31x30 TM7 hydrophobic
Neurotensin Y351 7.35x34 TM7 hydrophobic

NGL is a WebGL based 3D viewer powered by MMTF.

Download PDB file

Snake plot — Download: PNG | SVG
ICL1 K S L Q ICL1ECL1 H H P W A F ECL1ICL2 P F K A K T L M ICL2ECL2 G L Q N R S G D G T H P G G L V C T P I V D ECL2ICL3 R V C T V G T H N G L E H S T F N M T I E ICL3ECL3 S D E Q W ECL3N-term M H L N S S V P Q G T P G E P D A Q P F S G P Q S E M E A T F L A L S L S N G S G N T S E S D T A G P N S D L D V N T D N-termC-term P G W R H R R K K R P T F S R K P N S M S S N H A F S T S A T R E T L Y C-term I Y S K V L V T A I Y L A L F V V G T V G N S V T A F T L A R K S L Q S T V H Y H L G S L A L S D L L I L L L A M P V E L Y N F I W V G D A G C R G Y Y F L R D A C T Y A T A L N V A S L S V E R Y L A I C H S R S R T K K F I S A I W L A S A L L A I P M L F T M T A T V K V V I Q V N T F M S F L F P M L V I S I L N T V I A N K L T V M V H Q A A E Q G P G R V Q A L R H G V L V L R A V V I A F V V C W L P Y H V R R L M F C Y I T T F L F D F Y H Y F Y M L T N A L F Y V S S A I N P I L Y N L V S A N F L S L C F R Q V T L A C
Helix box plot — Download: PNG | SVG S N G V T G V V F L A L Y I A T V L V K 1 G S L A L S D L L I L L L A M P V E L Y N 2 S A V N L A T A Y T C A D R L F Y Y G R 3 T K K F I S A I W L A S A L L A I P M 4 N L I S I V L M P F L F S M F T N V Q I V 5 R A V V I A F V V C W L P Y H V R R L M 6 I P N I A S S V Y F L A N T L M Y F Y 7

GPCRdb(A)
GPCRdb(A)
NTS1 receptor
TM2
2x64 2.65x64 F128
TM3
3x29 3.29x29 Y146
ECL2
45x50 45.50x50 C225
45x51 45.51x51 T226
45x52 45.52x52 P227
TM5
5x36 5.35x36 V234
5x40 5.39x40 I238
TM6
6x54 6.54x54 R327
6x55 6.55x55 R328
6x58 6.58x58 F331
6x59 6.59x59 C332
TM7
7x24 7.25x24 T341
7x27 7.28x27 F344
7x30 7.31x30 Y347
7x34 7.35x34 Y351