Structure information

P2Y12 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

4NTJ

SPECIES

Homo sapiens

RESOLUTION

2.620

PREFERRED CHAIN

A

PUBLICATION DATE

March 26, 2014

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
AZD1283 Y105 3.33x33 TM3 aromatic (face-to-face)
AZD1283 Y109 3.37x37 TM3 polar (hydrogen bond)
AZD1283 V190 5.39x39 TM5 hydrophobic
AZD1283 F252 6.51x51 TM6 aromatic (face-to-edge)
AZD1283 R256 6.55x55 TM6 polar (charge-assisted hydrogen bond)
AZD1283 Y259 6.58x58 TM6 hydrophobic
AZD1283 K280 7.35x34 TM7 polar (charge-assisted hydrogen bond)

Ligands

AZD1283

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Residue Diagrams

G N T I L G V F F L V T Y L L P F L V Q 1 K N T V I S D L L M I L T F P F K I L S 2 L G L F S I S I Y M T F Y F I V S T V Q 3 A K I L S V V I W A F M F L L S L P N M 4 Y C V I V I L F N I W F I V Q C I Y N V 5 V F I I I A V F I F C F V P F H F A R I P 6 F P D L C A N L S T L W L T S E K V Y 7
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ICL1 R S K ICL1ECL1 L G T ECL1ICL2 P F K T S N P K ICL2ECL2 N R Q P R D K N V K K C S F L K S ECL2ICL3 R G V G K V ICL3ECL3 D V F ECL3N-term M Q A V D N L T S A P G N T S L C T R D N-termC-term L K C P N S A T S L S Q D N R K K E Q D G G D P N E E T P M C-term Y K I T Q V L F P L L Y T V L F F V G L I T N G L A M R I F F Q I S N F I I F L K N T V I S D L L M I L T F P F K I L S D A K G P L R T F V C Q V T S V I F Y F T M Y I S I S F L G L I T I D R Y Q K T T R N L L G A K I L S V V I W A F M F L L S L P N M I L T E F G L V W H E I V N Y I C Q V I F W I N F L I V I V C Y T L I T K E L Y R S Y V R T P R K K V N V K V F I I I A V F F I C F V P F H F A R I P Y T L S Q T R D C T A E N T L F Y V K E S T L W L T S L N A C L D P F I Y F F L C K S L I S F R N S M
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Residue Table


GPCRdb(A)
GPCRdb(A)
P2Y12 receptor
TM3
3x33 3.33x33 Y105
3x37 3.37x37 Y109
TM5
5x39 5.39x39 V190
TM6
6x51 6.51x51 F252
6x55 6.55x55 R256
6x58 6.58x58 Y259
TM7
7x34 7.35x34 K280