PDB
4OO9
Resolution
2.6 Å
Released
July 2, 2014
Receptor
mGlu5
Class
C
Species
Homo sapiens
Ligand
Function
MAVOGLURANT
NAM
Reference
10.1038/NATURE13396

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Ligand Amino Acid Generic Number Segment Interaction Type
MAVOGLURANT G624 2.45x45 TM2 Van der Waals
MAVOGLURANT I625 2.46x46 TM2 hydrophobic
MAVOGLURANT G628 2.49x49 TM2 Van der Waals
MAVOGLURANT I651 3.36x36 TM3 Van der Waals
MAVOGLURANT S654 3.39x39 TM3 Van der Waals
MAVOGLURANT P655 3.40x40 TM3 hydrophobic
MAVOGLURANT S658 3.43x43 TM3 Van der Waals
MAVOGLURANT Y659 3.44x44 TM3 hydrophobic
MAVOGLURANT V740 5.40x40 TM5 Van der Waals
MAVOGLURANT P743 5.43x43 TM5 Van der Waals
MAVOGLURANT L744 5.44x44 TM5 hydrophobic
MAVOGLURANT N747 5.47x47 TM5 polar (hydrogen bond)
MAVOGLURANT I751 5.51x51 TM5 hydrophobic
MAVOGLURANT W785 6.50x50 TM6 Van der Waals
MAVOGLURANT F788 6.53x53 TM6 hydrophobic
MAVOGLURANT M802 7.32x33 TM7 hydrophobic
MAVOGLURANT S805 7.35x36 TM7 polar (hydrogen bond)
MAVOGLURANT V806 7.36x37 TM7 hydrophobic
MAVOGLURANT S809 7.39x40 TM7 polar (hydrogen bond)
MAVOGLURANT A810 7.40x41 TM7 hydrophobic
MAVOGLURANT A813 7.43x44 TM7 hydrophobic

NGL is a WebGL based 3D viewer powered by MMTF.

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ICL1 T R D P V V K S S ICL1ECL1 A K P ECL1ICL2 A G S K K K I C T K K P R F M ICL2ECL2 P P D I M H D Y P S I R E V Y L I C N T ECL2ICL3 R N V P A N F N ICL3ECL3 N ECL3N-term M V L L L I L S V L L L K E D V R G S A Q S S E R R V V A H M P G D I I I G A L F S V H H Q P T V D K V H E R K C G A V R E Q Y G I Q R V E A M L H T L E R I N S D P T L L P N I T L G C E I R D S C W H S A V A L E Q S I E F I R D S L I S S E E E E G L V R C V D G S S S S F R S K K P I V G V I G P G S S S V A I Q V Q N L L Q L F N I P Q I A Y S A T S M D L S D K T L F K Y F M R V V P S D A Q Q A R A M V D I V K R Y N W T Y V S A V H T E G N Y G E S G M E A F K D M S A K E G I C I A H S Y K I Y S N A G E Q S F D K L L K K L T S H L P K A R V V A C F C E G M T V R G L L M A M R R L G L A G E F L L L G S D G W A D R Y D V T D G Y Q R E A V G G I T I K L Q S P D V K W F D D Y Y L K L R P E T N H R N P W F Q E F W Q H R F Q C R L E G F P Q E N S K Y N K T C N S S L T L K T H H V Q D S K M G F V I N A I Y S M A Y G L H N M Q M S L C P G Y A G L C D A M K P I D G R K L L E S L M K T N F T G V S G D T I L F D E N G D S P G R Y E I M N F K E M G K D Y F D Y I N V G S W D N G E L K M D D D E V W S K K S N I I R S V C S E P C E K G Q I K V I R K G E V S C C W T C T P C K E N E Y V F D E Y T C K A C Q L G S W P T D D L T G C D L I P V Q Y L R W G D N-termC-term T V V R M H V G D G K S S S A A S R S S S L V N L W K R R G S S G E T L R Y K D R R L A Q H K S E I E C F T P K G S M G N G G R A T M S S S N G K S V T W A Q N E K S S R G Q H L W Q R L S I H I N K K E N P N Q T A V I K P F P K S T E S R G L G A G A G A G G S A G G V G A T G G A G C A G A G P G G P E S P D A G P K A L Y D V A E A E E H F P A P A R P R S P S P I S T L S H R A G S A S R T D D D V P S L H S E P V A R S S S S Q G S L M E Q I S S V V T R F T A N I S E L N S M M L S T A A P S P G V G A P L C S S Y L I P K E I Q L P T T M T T F A E I Q P L P A I E V T G G A Q P A A G A Q A A G D A A R E S P A A G P E A A A A K P D L E E L V A L T P P S P F R D S V D S G S T T P N S P V S E S A L C I P S S P K Y D T L I I R D Y T Q S S S S L C-term P E P I A A V V F A C L G L L A T L F V T V V F I I Y S R E L C Y I I L A G I C L G Y L C T F C L I K Q I Y C Y L Q R I G I G L S P A M S Y S A L V T K T N R I A R I L S A C A Q L V I A F I L I C I Q L G I I V A L F I M E T N L G V V T P L G Y N G L L I L S C T F Y A F K T E A K Y I A F T M Y T T C I I W L A F V P I Y F G S Y K I I T M C F S V S L S A T V A L G C M F V P K V Y I I L A K P E R A F T N V R S T S
Helix box plot — Download: PNG | SVG L T A L L G L C A F V V A A I P E P 1 Y I I L A G I C L G Y L C T F C L I 2 T V L A S Y S M A P S L G I G I R Q L Y 3 Q L V I A F I L I C I Q L G I I V A L F 4 A Y F T C S L I L L G N Y G L P T V V G 5 A F T M Y T T C I I W L A F V P I Y F G 6 G L A V T A S L S V S F C M T I I K Y 7

GPCRdb(A)
GPCRdb(C)
mGlu5 receptor
TM2
2x49 2.45x45 G624
2x50 2.46x46 I625
2x53 2.49x49 G628
TM3
3x32 3.36x36 I651
3x35 3.39x39 S654
3x36 3.40x40 P655
3x39 3.43x43 S658
3x40 3.44x44 Y659
TM5
5x40 5.40x40 V740
5x43 5.43x43 P743
5x44 5.44x44 L744
5x47 5.47x47 N747
5x51 5.51x51 I751
TM6
6x48 6.50x50 W785
6x51 6.53x53 F788
TM7
7x38 7.32x33 M802
7x41 7.35x36 S805
7x42 7.36x37 V806
7x45 7.39x40 S809
7x46 7.40x41 A810
7x49 7.43x44 A813