Structure information

OX2 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

4S0V

SPECIES

Homo sapiens

RESOLUTION

2.500

PREFERRED CHAIN

A

REFERENCE

10.1038/NATURE14035

PUBLICATION DATE

Jan. 14, 2015

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
suvorexant W120 23.50x50 ECL1 hydrophobic
suvorexant I130 3.28x28 TM3 hydrophobic
suvorexant P131 3.29x29 TM3 hydrophobic
suvorexant F227 5.42x43 TM5 aromatic (edge-to-face)
suvorexant I320 6.51x51 TM6 hydrophobic
suvorexant N324 6.55x55 TM6 polar (hydrogen bond)
suvorexant N324 6.55x55 TM6 Van der Waals
suvorexant H350 7.39x38 TM7 Van der Waals
suvorexant H350 7.39x38 TM7 aromatic (face-to-face)
suvorexant V353 7.42x41 TM7 hydrophobic
suvorexant Y354 7.43x42 TM7 Van der Waals
suvorexant Y354 7.43x42 TM7 hydrophobic

Ligands

suvorexant

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Residue Diagrams

V N G I L A V V F V I I Y G A I L V W E 1 V N L S L A D V L V T T I C L P A T L V V 2 C S L T L V S V S V S V T Q L Y P I V K 3 A R N S I V I I W I V S C I I M I P Q 4 Y A L V M L C L P A M Y T V L F F C I H Y 5 M I V L L V F A I C Y L P I S I L N V L 6 I P N A A S N A Y V L W H S F T F W A 7
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ICL1 H H M R ICL1ECL1 T W F F ECL1ICL2 P L M F K S ICL2ECL2 E C S T V F P G L A N K T T L F T V C D E R W G G E ECL2ICL3 G T S S V V Q R K W K P L Q P V S Q P R G P G Q P T K S R M S A ICL3ECL3 G M F A H T E ECL3N-term M S G T K L E D S P P C R N W S S A S E L N E T Q E P F L N P T D Y D D E E F L R Y L W R E Y L H P K E N-termC-term G V H H R Q E D R L T R G R T S T E S R K S L T T Q I S N F D N I S K L S E Q V V L T S I S T L P A A N G A G P L Q N W C-term Y E W V L I A G Y I I V F V V A L I G N V L V C V A V W K N T V T N Y F I V N L S L A D V L V T I T C L P A T L V V D I T E G Q S L C K V I P Y L Q T V S V S V S V L T L S C I A L D R W Y A I C H T A K R A R N S I V I I W I V S C I I M I P Q A I V M I Y P K M Y H I C F F L V T Y M A P L C L M V L A Y L Q I F R K L W C R Q I P V A A E I K Q I R A R R K T A R M L M I V L L V F A I C Y L P I S I L N V L K R V F D R E T V Y A W F T F S H W L V Y A N S A A N P I I Y N F L S G K F K A C C L F R E E A F S C
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Residue Table


GPCRdb(A)
GPCRdb(A)
OX2 receptor
ECL1
23x50 23.50x50 W120
TM3
3x28 3.28x28 I130
3x29 3.29x29 P131
TM5
5x43 5.42x43 F227
TM6
6x51 6.51x51 I320
6x55 6.55x55 N324
TM7
7x38 7.39x38 H350
7x41 7.42x41 V353
7x42 7.43x42 Y354