Structure information

US28

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

4XT1

SPECIES

Human cytomegalovirus

RESOLUTION

2.890

PREFERRED CHAIN

A

REFERENCE

10.1126/SCIENCE.AAA5026

PUBLICATION DATE

March 4, 2015

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
CX<sub>3</sub>CL1 D15 N-term polar (charge-assisted hydrogen bond)
CX<sub>3</sub>CL1 E18 N-term polar (charge-assisted hydrogen bond)
CX<sub>3</sub>CL1 A20 N-term Van der Waals
CX<sub>3</sub>CL1 A20 N-term polar (hydrogen bond with backbone)
CX<sub>3</sub>CL1 T21 N-term Van der Waals
CX<sub>3</sub>CL1 P22 N-term hydrophobic
CX<sub>3</sub>CL1 P22 N-term Van der Waals
CX<sub>3</sub>CL1 C23 N-term polar (hydrogen bond with backbone)
CX<sub>3</sub>CL1 C23 N-term Van der Waals
CX<sub>3</sub>CL1 V24 N-term hydrophobic
CX<sub>3</sub>CL1 V24 N-term Van der Waals
CX<sub>3</sub>CL1 F25 1.24x24 TM1 polar (hydrogen bond with backbone)
CX<sub>3</sub>CL1 F25 1.24x24 TM1 Van der Waals
CX<sub>3</sub>CL1 T26 1.25x25 TM1 Van der Waals
CX<sub>3</sub>CL1 L29 1.28x28 TM1 Van der Waals
CX<sub>3</sub>CL1 L29 1.28x28 TM1 hydrophobic
CX<sub>3</sub>CL1 Y40 1.39x39 TM1 Van der Waals
CX<sub>3</sub>CL1 Y40 1.39x39 TM1 polar (hydrogen bond)
CX<sub>3</sub>CL1 W89 2.60x60 TM2 Van der Waals
CX<sub>3</sub>CL1 W89 2.60x60 TM2 aromatic (face-to-edge)
CX<sub>3</sub>CL1 Y92 2.63x63 TM2 Van der Waals
CX<sub>3</sub>CL1 Y92 2.63x63 TM2 polar (hydrogen bond with backbone)
CX<sub>3</sub>CL1 L93 2.64x64 TM2 Van der Waals
CX<sub>3</sub>CL1 L93 2.64x64 TM2 hydrophobic
CX<sub>3</sub>CL1 D95 2.66x66 TM2 Van der Waals
CX<sub>3</sub>CL1 T108 3.29x29 TM3 Van der Waals
CX<sub>3</sub>CL1 F111 3.32x32 TM3 aromatic (face-to-face)
CX<sub>3</sub>CL1 F111 3.32x32 TM3 Van der Waals
CX<sub>3</sub>CL1 Y112 3.33x33 TM3 polar (hydrogen bond)
CX<sub>3</sub>CL1 V166 ECL2 Van der Waals
CX<sub>3</sub>CL1 Q172 ECL2 polar (hydrogen bond)
CX<sub>3</sub>CL1 Q172 ECL2 polar (hydrogen bond)
CX<sub>3</sub>CL1 C173 45.50x50 ECL2 Van der Waals
CX<sub>3</sub>CL1 M174 45.51x51 ECL2 hydrophobic
CX<sub>3</sub>CL1 M174 45.51x51 ECL2 Van der Waals
CX<sub>3</sub>CL1 T175 45.52x52 ECL2 Van der Waals
CX<sub>3</sub>CL1 T175 45.52x52 ECL2 polar (hydrogen bond)
CX<sub>3</sub>CL1 D176 ECL2 Van der Waals
CX<sub>3</sub>CL1 Y177 ECL2 Van der Waals
CX<sub>3</sub>CL1 Y177 ECL2 polar (hydrogen bond with backbone)
CX<sub>3</sub>CL1 D178 ECL2 polar (charge-assisted hydrogen bond)
CX<sub>3</sub>CL1 Y244 6.51x51 TM6 Van der Waals
CX<sub>3</sub>CL1 K270 7.32x31 TM7 Van der Waals
CX<sub>3</sub>CL1 L273 7.35x34 TM7 Van der Waals
CX<sub>3</sub>CL1 L273 7.35x34 TM7 hydrophobic
CX<sub>3</sub>CL1 I274 7.36x35 TM7 Van der Waals
CX<sub>3</sub>CL1 I274 7.36x35 TM7 hydrophobic
CX<sub>3</sub>CL1 E277 7.39x38 TM7 polar (charge-assisted hydrogen bond)

Ligands

CX<sub>3</sub>CL1

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Residue Diagrams

F N G I S G F L F V V G Y L F L T V P K 1 I N L A A A D L L F V C T L P L W M Q Y 2 E T I F C L S A F M A V Y F C A T L L T 3 A C L F S I F W W I F A V I I A I P H 4 Y C Y S I V S L P I V F A G L M L E V N L 5 I A V V L V F I I F W L P Y H L T L F V 6 L P N L C C H C F A L S E T L I L A R 7
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ICL1 R R I Q ICL1ECL1 H N S L ECL1ICL2 M R Y R ICL2ECL2 V V T K K D N Q C M T D Y D Y L E V ECL2ICL3 Q S R ICL3ECL3 W I S S ECL3N-term M T P T T T T A E L T T E F D Y D E D A T P C V N-termC-term Q R L F S R D V S W Y H S M S F S R R S S P S R R E T S S D T L S D E V C R V S Q I I P C-term F T D V L N Q S K P V T L F L Y G V V F L F G S I G N F L V I F T I T W R C S G D V Y F I N L A A A D L L F V C T L P L W M Q Y L L D A S V P C T L L T A C F Y V A M F A S L C F I T E I A L D R Y Y A I V Y P V K Q A C L F S I F W W I F A V I I A I P H F M S Y P I I L N V E L M L G A F V I P L S V I S Y C Y Y R I S R I V A V S H K G R I V R V L I A V V L V F I I F W L P Y H L T L F V D T L K L L K S C E F E R S L K R A L I L T E S L A F C H C C L N P L L Y V F V G T K L H C F R F R Q E L L A E
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Residue Table


GPCRdb(A)
GPCRdb(A)
US28
TM1
1x24 1.24x24 F25
1x25 1.25x25 T26
1x28 1.28x28 L29
1x39 1.39x39 Y40
TM2
2x60 2.60x60 W89
2x63 2.63x63 Y92
2x64 2.64x64 L93
2x66 2.66x66 D95
TM3
3x29 3.29x29 T108
3x32 3.32x32 F111
3x33 3.33x33 Y112
ECL2
45x50 45.50x50 C173
45x51 45.51x51 M174
45x52 45.52x52 T175
TM6
6x51 6.51x51 Y244
TM7
7x31 7.32x31 K270
7x34 7.35x34 L273
7x35 7.36x35 I274
7x38 7.39x38 E277