PDB
4Z36
Resolution
2.9 Å
Released
June 3, 2015
Receptor
LPA1
Class
A
Species
Homo sapiens
Ligand
Function
ONO-3080573
Antagonist
Reference
10.1016/J.CELL.2015.06.002

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Ligand Amino Acid Generic Number Segment Interaction Type
ONO-3080573 K39 N-term aromatic (pi-cation)
ONO-3080573 V52 1.35x35 TM1 hydrophobic
ONO-3080573 Y102 2.57x57 TM2 Van der Waals
ONO-3080573 M106 2.61x61 TM2 hydrophobic
ONO-3080573 T109 ECL1 Van der Waals
ONO-3080573 Q125 3.29x29 TM3 polar (hydrogen bond)
ONO-3080573 I128 3.32x32 TM3 Van der Waals
ONO-3080573 D129 3.33x33 TM3 Van der Waals
ONO-3080573 L132 3.36x36 TM3 hydrophobic
ONO-3080573 M198 ECL2 hydrophobic
ONO-3080573 L207 5.40x40 TM5 Van der Waals
ONO-3080573 W210 5.43x43 TM5 Van der Waals
ONO-3080573 W271 6.48x48 TM6 hydrophobic
ONO-3080573 G274 6.51x51 TM6 Van der Waals
ONO-3080573 L275 6.52x52 TM6 Van der Waals
ONO-3080573 L277 6.54x54 TM6 hydrophobic
ONO-3080573 L278 6.55x55 TM6 hydrophobic
ONO-3080573 E293 7.35x34 TM7 hydrophobic
ONO-3080573 K294 7.36x35 TM7 polar (charge-charge)
ONO-3080573 K294 7.36x35 TM7 polar (hydrogen bond)
ONO-3080573 F296 7.38x37 TM7 hydrophobic
ONO-3080573 L297 7.39x38 TM7 hydrophobic
ONO-3080573 A300 7.42x41 TM7 Van der Waals

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Snake plot — Download: PNG | SVG
ICL1 R R F H ICL1ECL1 T G P N T R R L ECL1ICL2 M Q L H T R M ICL2ECL2 W N C I C D I E N C S N M A P L Y ECL2ICL3 R H S S ICL3ECL3 P Q C ECL3N-term M A A I S T S I P V I S Q P Q F T A M N E P Q C F Y N E S I A F F Y N R S G K H L A T E W N N-termC-term C Q R S E N P T G P T E G S D R S A S S L N H T I L A G V H S N D H S V V C-term T V S K L V M G L G I T V C I F I M L A N L L V M V A I Y V N F P I Y Y L M A N L A A A D F F A G L A Y F Y L M F N T V S T W L L R Q G L I D T S L T A S V A N L L A I A I E R H I T V F R S N R R V V V V I V V I W T M A I V M G A I P S V G S D S Y L V F W A I F N L V T F V V M V V L Y A H I F G Y V R Q R T M R M S G P R R N R D T M M S L L K T V V I V L G A F I I C W T P G L V L L L L D V C C D V L A Y E K F F L L L A E F N S A M N P I I Y S Y R D K E F R Q M S A T I L C
Helix box plot — Download: PNG | SVG L N A L M I F I C V T I G L G M V L K S 1 A N L A A A D F F A G L A Y F Y L M F N 2 A L L N A V S A T L S T D I L G Q R L L 3 V V V V I V V I W T M A I V M G A I P S 4 Y L V V M V V F T V L N F I A W F V L Y 5 V I V L G A F I I C W T P G L V L L L L 6 I P N M A S N F E A L L L F F K E Y A 7

GPCRdb(A)
GPCRdb(A)
LPA1 receptor
TM1
1x35 1.35x35 V52
TM2
2x57 2.57x57 Y102
2x61 2.61x61 M106
TM3
3x29 3.29x29 Q125
3x32 3.32x32 I128
3x33 3.33x33 D129
3x36 3.36x36 L132
TM5
5x40 5.40x40 L207
5x43 5.43x43 W210
TM6
6x48 6.48x48 W271
6x51 6.51x51 G274
6x52 6.52x52 L275
6x54 6.54x54 L277
6x55 6.55x55 L278
TM7
7x34 7.35x34 E293
7x35 7.36x35 K294
7x37 7.38x37 F296
7x38 7.39x38 L297
7x41 7.42x41 A300