Structure information

AT1 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

4ZUD

SPECIES

Homo sapiens

RESOLUTION

2.800

PREFERRED CHAIN

A

PUBLICATION DATE

Oct. 7, 2015

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
Olmesartan Y35 1.39x39 TM1 polar (hydrogen bond)
Olmesartan W84 2.60x60 TM2 aromatic (face-to-face)
Olmesartan V108 3.32x32 TM3 hydrophobic
Olmesartan S109 3.33x33 TM3 polar (hydrogen bond)
Olmesartan R167 4.64x65 TM4 polar (charge-charge)
Olmesartan R167 4.64x65 TM4 polar (charge-assisted hydrogen bond)
Olmesartan R167 4.64x65 TM4 polar (charge-assisted hydrogen bond)
Olmesartan R167 4.64x65 TM4 polar (charge-charge)
Olmesartan I288 7.39x38 TM7 hydrophobic

Ligands

Olmesartan

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Residue Diagrams

S N G F I G V V F I I S Y L T P I M V F 1 L N L A L A D L C F L L T L P L W A V Y 2 C T L L F V S A Y L N F S V S A S A I K 3 A K V T C I I I W L L A G L A S L P A 4 Y S T L I I L F P F L F G L I N K T L G L 5 M A I V L F F F F S W I P H Q I F T F L 6 L P N L C N N F Y A I C I T I P M A T 7
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ICL1 M K L K ICL1ECL1 Y R W P F ECL1ICL2 P M K S R L R R ICL2ECL2 N V F F I E N T N I T V C A F H Y E S Q N S T ECL2ICL3 Y E I Q K N K ICL3ECL3 I I R ECL3N-term M I L N S S T E D G I K R I Q D D C P K A G R N-termC-term P P K A K S H S N L S T K M S T L S Y R P S D N V S S S T K K P A P C F E V E C-term H N Y I F V M I P T L Y S I I F V V G I F G N S L V V I V I Y F Y T V A S V F L L N L A L A D L C F L L T L P L W A V Y T A M E G N Y L C K I A S A S V S F N L Y A S V F L L T C L S I D R Y L A I V H T M L V A K V T C I I I W L L A G L A S L P A I I H R L P I G L G L T K N I L G F L F P F L I I L T S Y T L I W K A L K K A P R N D D I F K I I M A I V L F F F F S W I P H Q I F T F L D V L I Q L G D C R I A D I V D T A M P I T I C I A Y F N N C L N P L F Y G F L G K K F L Q I F K R Y L L K Y
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Residue Table


GPCRdb(A)
GPCRdb(A)
AT1 receptor
TM1
1x39 1.39x39 Y35
TM2
2x60 2.60x60 W84
TM3
3x32 3.32x32 V108
3x33 3.33x33 S109
TM4
4x65 4.64x65 R167
TM7
7x38 7.39x38 I288