PDB
5DHG
Resolution
3.0 Å
Released
Oct. 21, 2015
Receptor
NOP
Class
A
Species
Homo sapiens
Ligand
Function
CHEMBL1783826
Antagonist
Reference
10.1016/J.STR.2015.07.024

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Ligand Amino Acid Generic Number Segment Interaction Type
CHEMBL1783826 Q107 2.60x60 TM2 Van der Waals
CHEMBL1783826 D110 2.63x63 TM2 hydrophobic
CHEMBL1783826 W116 23.50x50 ECL1 hydrophobic
CHEMBL1783826 V126 3.28x28 TM3 Van der Waals
CHEMBL1783826 I127 3.29x29 TM3 hydrophobic
CHEMBL1783826 D130 3.32x32 TM3 polar (hydrogen bond)
CHEMBL1783826 D130 3.32x32 TM3 polar (charge-charge)
CHEMBL1783826 D130 3.32x32 TM3 hydrophobic
CHEMBL1783826 Y131 3.33x33 TM3 aromatic (pi-cation)
CHEMBL1783826 Y131 3.33x33 TM3 hydrophobic
CHEMBL1783826 M134 3.36x36 TM3 hydrophobic
CHEMBL1783826 F135 3.37x37 TM3 hydrophobic
CHEMBL1783826 C200 45.50x50 ECL2 Van der Waals
CHEMBL1783826 V202 45.52x52 ECL2 hydrophobic
CHEMBL1783826 I219 5.42x43 TM5 hydrophobic
CHEMBL1783826 S223 5.46x461 TM5 Van der Waals
CHEMBL1783826 W276 6.48x48 TM6 hydrophobic
CHEMBL1783826 V279 6.51x51 TM6 hydrophobic
CHEMBL1783826 Q280 6.52x52 TM6 Van der Waals
CHEMBL1783826 V283 6.55x55 TM6 hydrophobic
CHEMBL1783826 T305 7.39x38 TM7 Van der Waals
CHEMBL1783826 Y309 7.43x42 TM7 Van der Waals

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Snake plot — Download: PNG | SVG
ICL1 T K M K ICL1ECL1 F W P F ECL1ICL2 P I R A L D V R ICL2ECL2 S A Q V E D E E I E C L V E I P T ECL2ICL3 R L L S G ICL3ECL3 V Q P S ECL3N-term M E P L F P A P F W E V I Y G S H L Q G N L S L L S P N H S L L P P H L L L N A S H G A F L P N-termC-term A S A L R R D V Q V S D R V R S I A K D V A L A C K T S E T V P R P A C-term L G L K V T I V G L Y L A V C V G G L L G N C L V M Y V I L R H T A T N I Y I F N L A L A D T L V L L T L P F Q G T D I L L G G N A L C K T V I A I D Y Y N M F T S T F T L T A M S V D R Y V A I C H T S S K A Q A V N V A I W A L A S V V G V P V A I M G P Q D Y W G P V F A I C I F L F S F I V P V L V I S V C Y S L M I R R L R G V S R E K D R N L R R I T R L V L V V V A V F V G C W T P V Q V F V L A Q G L G S E T A V A I L R F C T A L G Y V N S C L N P I L Y A F L D E N F R K F K A C F C C
Helix box plot — Download: PNG | SVG C N G L L G G V C V A L Y L G V I T V K 1 F N L A L A D T L V L L T L P F Q G T D 2 A T L T F T S T F M N Y Y D I A I V T K 3 A Q A V N V A I W A L A S V V G V P V A 4 Y C V S I V L V P V I F S F L F I C I A F 5 L V V V A V F V G C W T P V Q V F V L A 6 I P N L C S N V Y G L A T C F R L I A 7

GPCRdb(A)
GPCRdb(A)
NOP receptor
TM2
2x60 2.60x60 Q107
2x63 2.63x63 D110
ECL1
23x50 23.50x50 W116
TM3
3x28 3.28x28 V126
3x29 3.29x29 I127
3x32 3.32x32 D130
3x33 3.33x33 Y131
3x36 3.36x36 M134
3x37 3.37x37 F135
ECL2
45x50 45.50x50 C200
45x52 45.52x52 V202
TM5
5x43 5.42x43 I219
5x461 5.46x461 S223
TM6
6x48 6.48x48 W276
6x51 6.51x51 V279
6x52 6.52x52 Q280
6x55 6.55x55 V283
TM7
7x38 7.39x38 T305
7x42 7.43x42 Y309