Structure information

glucagon receptor

PROTEIN CLASS

Class B1 (Secretin)

PDB CODE

5EE7

SPECIES

Homo sapiens

RESOLUTION

2.500

PREFERRED CHAIN

A

PUBLICATION DATE

April 20, 2016

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
Octaethylene glycol monoethyl ether Y145 1.43x43 TM1 hydrophobic
Octaethylene glycol monoethyl ether Y149 1.47x47 TM1 polar (hydrogen bond)
Octaethylene glycol monoethyl ether V191 2.64x64 TM2 hydrophobic
Octaethylene glycol monoethyl ether I194 2.67x67 TM2 hydrophobic
Octaethylene glycol monoethyl ether R199 2.72x72 TM2 polar (charge-assisted hydrogen bond)
Octaethylene glycol monoethyl ether R199 2.72x72 TM2 polar (charge-assisted hydrogen bond)
Octaethylene glycol monoethyl ether I235 3.40x40 TM3 hydrophobic
Octaethylene glycol monoethyl ether Y239 3.44x44 TM3 polar (hydrogen bond)
Octaethylene glycol monoethyl ether M301 ECL2 polar (hydrogen bond with backbone)
MK-0893 R346 6.37x37 TM6 polar (charge-charge)
MK-0893 R346 6.37x37 TM6 polar (charge-charge)
MK-0893 A348 6.39x39 TM6 hydrophobic
MK-0893 S350 6.41x41 TM6 polar (hydrogen bond)
Octaethylene glycol monoethyl ether H361 6.52x52 TM6 polar (hydrogen bond)
Octaethylene glycol monoethyl ether F365 6.56x56 TM6 hydrophobic
Octaethylene glycol monoethyl ether L386 7.43x42 TM7 hydrophobic
Octaethylene glycol monoethyl ether Q392 7.49x49 TM7 polar (hydrogen bond)
MK-0893 L403 ICL4 hydrophobic
MK-0893 N404 8.47x47 H8 polar (charge-assisted hydrogen bond)
MK-0893 K405 8.48x48 H8 polar (hydrogen bond with backbone)

Ligands

Octaethylene glycol monoethyl ether

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MK-0893

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Residue Diagrams

L L A G L S L S Y G V T Y M V Q F S S Y 1 A N L F A S F V L K A S S V L V I D G L 2 V L L W C Y N A V I G Y Q M F V A A V R 3 F F S L Y L G G I W G A P M L F V V P W A 4 F I F F N I L I A L F V P F R L I W W 5 L T L I P L L G V H E V V F A F V T D 6 V A V L L G Q F S S L F L D F F L K A 7
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ICL1 S K L H ICL1ECL1 Q K I G D D L S V S T W L S D G ECL1ICL2 A T L P E R ICL2ECL2 N V Q C W T S N D N M G F ECL2ICL3 R Q M H H T ICL3ECL3 E H A Q ECL3N-term M P P C Q P Q R P L L L L L L L L A C Q P Q V P S A Q V M D F L F E K W K L Y G D Q C H H N L S L L P P P T E L V C N R T F D K Y S C W P D T P A N T T A N I S C P W Y L P W H H K V Q H R F V F K R C G P D G Q W V R G P R G Q P W R D A S Q C Q M D G E E I E V N-termC-term T S N H R A S S S P G H G P P S K E L Q F G R G G G S Q D S S A E T P L A G G L P R L A E S P F C-term Q K E V A K M Y S S F Q V M Y T V G Y S L S L G A L L L A L A I L G G L C T R N A I H A N L F A S F V L K A S S V L V I D G L L R T R Y S A V A G C R V A A V F M Q Y G I V A N Y C W L L V E G L Y L H N L L G L S F F S L Y L G I G W G A P M L F V V P W A V V K C L F E W W I L R F P V F L A I L I N F F I F V R I V Q L L V A K L R A D Y K F R L A K S T L T L I P L L G V H E V V F A F V T D G T L R S A K L F F D L F L S S F Q G L L V A V L Y C F L N K E L R R W R L W E E V Q S E R W H R G K V L R N
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Residue Table


GPCRdb(A)
GPCRdb(B)
glucagon receptor
TM1
1x39 1.43x43 Y145
1x43 1.47x47 Y149
TM2
2x57 2.64x64 V191
2x60 2.67x67 I194
2x65 2.72x72 R199
TM3
3x36 3.40x40 I235
3x40 3.44x44 Y239
TM6
6x32 6.37x37 R346
6x34 6.39x39 A348
6x36 6.41x41 S350
6x47 6.52x52 H361
6x51 6.56x56 F365
TM7
7x38 7.43x42 L386
7x45 7.49x49 Q392
H8
8x47 8.47x47 N404
8x48 8.48x48 K405