Structure information

β1-adrenoceptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

5F8U

SPECIES

Meleagris gallopavo

RESOLUTION

3.350

PREFERRED CHAIN

A

REFERENCE

PUBLICATION DATE

Dec. 23, 2015

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
(S)-Cyanopindolol D121 3.32x32 TM3 polar (charge-assisted hydrogen bond)
(S)-Cyanopindolol D121 3.32x32 TM3 polar (charge-charge)
(S)-Cyanopindolol V122 3.33x33 TM3 hydrophobic
(S)-Cyanopindolol V125 3.36x36 TM3 hydrophobic
(S)-Cyanopindolol F201 45.52x52 ECL2 aromatic (edge-to-face)
(S)-Cyanopindolol S211 5.42x43 TM5 polar (hydrogen bond)
(S)-Cyanopindolol F306 6.51x51 TM6 hydrophobic
(S)-Cyanopindolol F307 6.52x52 TM6 aromatic (edge-to-face)
(S)-Cyanopindolol N310 6.55x55 TM6 polar (hydrogen bond)
(S)-Cyanopindolol N329 7.39x38 TM7 polar (hydrogen bond)
(S)-Cyanopindolol N329 7.39x38 TM7 polar (charge-assisted hydrogen bond)
(S)-Cyanopindolol N329 7.39x38 TM7 polar (hydrogen bond)

Ligands

(S)-Cyanopindolol

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Residue Diagrams

V N G A V I L L V V L A M L L S M G A E 1 T S L A C A D L V M G L L V V P F G A T L 2 V C L T E I S A T V C L V D L S T W C E 3 A K V I I C T V W A I S A L V S F L P I 4 Y V F I M I L L P I Y F S I I S S A I A Y 5 G I I M G V F T L C W L P F F L V N I V 6 I P N F A S N A Y G L W N F F V F L W 7
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ICL1 Q R L Q ICL1ECL1 T W L W ECL1ICL2 P F R Y Q S L M ICL2ECL2 W W R D E D P Q A L K C Y Q D P G C C D F V T ECL2ICL3 G R F Y G S Q E Q P Q P P P L P Q H Q P I L G N G R A S K ICL3ECL3 R D L V ECL3N-term M G D G W L P P D C G P H N R S G G G G A T A A P T G S R Q V S N-termC-term F P R K A D R R L H A G G Q P A P L P G G F I S T L G S P E H S P G G T W S D C N G G T R G G S E S S L E E R H S K T S R S E S K M E R E K N I L A T T R F Y C T F L G N G D K A V F C T V L R I V K L F E D A T C T C P H T H K L K M K W R F K Q H Q A C-term A E L L S Q Q W E A G M S L L M A L V V L L I V A G N V L V I A A I G R T T L T N L F I T S L A C A D L V M G L L V V P F G A T L V V R G G S F L C E C W T S L D V L C V T A S I E T L C V I A I D R Y L A I T S T R A R A K V I I C T V W A I S A L V S F L P I M M H N R A Y A I A S S I I S F Y I P L L I M I F V Y L R V Y R E A K E Q I R K I D R C E R K T S R V M A M R E H K A L K T L G I I M G V F T L C W L P F F L V N I V N V F N P D W L F V F F N W L G Y A N S A F N P I I Y C R S P D F K R F R K A L L C
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Residue Table


GPCRdb(A)
GPCRdb(A)
β1-adrenoceptor
TM3
3x32 3.32x32 D121
3x33 3.33x33 V122
3x36 3.36x36 V125
ECL2
45x52 45.52x52 F201
TM5
5x43 5.42x43 S211
TM6
6x51 6.51x51 F306
6x52 6.52x52 F307
6x55 6.55x55 N310
TM7
7x38 7.39x38 N329