Structure information

PAR2

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

5NDZ

SPECIES

Homo sapiens

RESOLUTION

3.600

PREFERRED CHAIN

A

REFERENCE

10.1038/NATURE22309

PUBLICATION DATE

May 3, 2017

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
AZ3451 A120 2.49x49 TM2 hydrophobic
AZ3451 L123 2.52x52 TM2 hydrophobic
AZ3451 F154 3.31x31 TM3 aromatic (face-to-edge)
AZ3451 A157 3.34x34 TM3 hydrophobic
AZ3451 W199 4.50x50 TM4 polar (hydrogen bond with backbone)
AZ3451 W199 4.50x50 TM4 Van der Waals
AZ3451 L203 4.54x54 TM4 polar (hydrogen bond with backbone)
AZ3451 L203 4.54x54 TM4 Van der Waals
AZ3451 Y210 4.61x62 TM4 polar (hydrogen bond)
AZ3451 Y210 4.61x62 TM4 Van der Waals
AZ3451 V211 4.62x63 TM4 Van der Waals

Ligands

AZ3451

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Residue Diagrams

G N S P L G V V F V I T Y V I P L F V T 1 A N L A L A D L L S V I W F P L K I A Y 2 C T M F L I S C Y M N G Y F F G I L V N 3 A I G I S L A I W L L I L L V T I P L 4 Y A S A T L F A P F L F V G I A L S L F Y 5 I V T V L A M Y I L C F T P S N L L L V V 6 F P D I C S N L T S L C L A V I Y L A 7
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ICL1 T K K K ICL1ECL1 G N N W I Y ECL1ICL2 P M G H S R K ICL2ECL2 V K Q T I F I P A L N I T T C H D V L P E Q L ECL2ICL3 A M D ICL3ECL3 G Q S H ECL3N-term M R S P S A A W L L G A A I L L A A S L S C S G T I Q G T N R S S K G R S L I G K V D G T S H V T G K G V T V E T V F S V D E F S A S V L T N-termC-term S V R T V K Q M Q V S L T S K K H S R K S S S Y S S S S T T V K T S Y C-term G K L T T V F L P I V Y T I V F V V G L P S N G M A L W V F L F R H P A V I Y M A N L A L A D L L S V I W F P L K I A Y H I H G E A L C N V L I G F F Y G N M Y C S I L F M T C L S V Q R Y W V I V N K A N I A I G I S L A I W L L I L L V T I P L Y V L V G D M F N Y F L S L A I G V F L F P A F L T A S A Y V L M I R M L R S S E N S E K K R K R A I K L I V T V L A M Y L I C F T P S N L L L V V H Y F L I K S Q V Y A L Y I V A L C L S T L N S C I D P F V Y Y F V S H D A K N R F R D H A L L C
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Residue Table


GPCRdb(A)
GPCRdb(A)
PAR2
TM2
2x49 2.49x49 A120
2x52 2.52x52 L123
TM3
3x31 3.31x31 F154
3x34 3.34x34 G157
TM4
4x50 4.50x50 W199
4x54 4.54x54 L203
4x62 4.61x62 Y210
4x63 4.62x63 V211