Structure information

GLP-1 receptor

PROTEIN CLASS

Class B1 (Secretin)

PDB CODE

5NX2

SPECIES

Homo sapiens

RESOLUTION

3.700

PREFERRED CHAIN

A

PUBLICATION DATE

June 14, 2017

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
Truncated protein agonist L32 N-term polar (hydrogen bond with backbone)
Truncated protein agonist W33 N-term polar (hydrogen bond with backbone)
Truncated protein agonist P137 N-term hydrophobic
Truncated protein agonist L141 1.36x36 TM1 hydrophobic
Truncated protein agonist L142 1.37x37 TM1 hydrophobic
Truncated protein agonist Y148 1.43x43 TM1 hydrophobic
Truncated protein agonist Y152 1.47x47 TM1 polar (hydrogen bond)
Truncated protein agonist Y152 1.47x47 TM1 polar (hydrogen bond)
Truncated protein agonist R190 2.60x60 TM2 polar (charge-assisted hydrogen bond)
Truncated protein agonist L201 2.71x71 TM2 hydrophobic
Truncated protein agonist Y205 2.75x75 TM2 polar (hydrogen bond)
Truncated protein agonist Y205 2.75x75 TM2 polar (hydrogen bond)
Truncated protein agonist A295 ECL2 hydrophobic
Truncated protein agonist C296 45.50x50 ECL2 hydrophobic
Truncated protein agonist R299 ECL2 polar (charge-assisted hydrogen bond)
Truncated protein agonist N300 ECL2 polar (hydrogen bond with backbone)
Truncated protein agonist N300 ECL2 polar (hydrogen bond)
Truncated protein agonist W306 5.36x37 TM5 hydrophobic
Truncated protein agonist D372 ECL3 polar (charge-assisted hydrogen bond)
Truncated protein agonist R380 7.35x34 TM7 polar (charge-charge)
Truncated protein agonist R380 7.35x34 TM7 polar (charge-charge)
Truncated protein agonist E387 7.42x41 TM7 polar (charge-assisted hydrogen bond)

Ligands

Truncated protein agonist

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Residue Diagrams

V L A S F S L A Y G V T Y I I Y L F L L 1 L N L F A S F I L R A L S V F I K D A A 2 V L L W Y Y N A A V C Y Q M L L F V L R 3 I F R L Y V S G I W G V P L L F V V P W G 4 F I L F N V G I A F L I P L R I I L W Y N 5 L T L I P L L G T H E V I F A F V M 6 I A V M L G Q F S T F S L E T F L K I 7
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ICL1 R H L H ICL1ECL1 T A A Q Q H Q W D G L L S Y Q D S ECL1ICL2 S V L ICL2ECL2 D E G C W T R N S ECL2ICL3 M ICL3ECL3 D E H A R ECL3N-term M A G A P G P L R L A L L L L G M V G R A G P R P Q G A T V S L W E T V Q K W R E Y R R Q C Q R S L T E D P P P A T D L F C N R T F D E Y A C W P D G E P G S F V N V S C P W Y L P W A S S V P Q G H V Y R F C T A E G L W L Q K D N S S L P W R D L S E C E E S K R G E R S S P N-termC-term S M K P L K C P T S S L S S G A T A G S S M Y T A T C Q A S C S C-term E E Q L L F L Y I I Y T V G Y A L S F S A L V I A S A I L L G F C T R N Y I H L N L F A S F I L R A L S V F I K D A A L K W M Y S L S C R L V F L L M Q Y C V A A N Y Y W L L V E G V Y L Y T L L A F S E Q W I F R L Y V S I G W G V P L L F V V P W G I V K Y L Y E N M N Y W L I I R L P I L F A I G V N F L I F V R V I C I V V S K L K A N L C K T D I K C R L A K S T L T L I P L L G T H E V I F A F V M G T L R F I K L F T E L S F T S F Q G L M V A I L Y C F V N N E F R K W R L I Q R V Q L E S W E R E H L H D S
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Residue Table


GPCRdb(A)
GPCRdb(B)
GLP-1 receptor
TM1
1x32 1.36x36 L141
1x33 1.37x37 L142
1x39 1.43x43 Y148
1x43 1.47x47 Y152
TM2
2x53 2.60x60 R190
2x64 2.71x71 L201
2x68 2.75x75 Y205
ECL2
45x50 45.50x50 C296
TM5
5x41 5.36x37 W306
TM7
7x30 7.35x34 R380
7x37 7.42x41 E387