Structure information

CCR2

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

5T1A

SPECIES

Homo sapiens

RESOLUTION

2.810

PREFERRED CHAIN

A

REFERENCE

10.1038/NATURE20605

PUBLICATION DATE

Dec. 14, 2016

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
BMS-681 V37 1.27x27 TM1 hydrophobic
BMS-681 L45 1.35x35 TM1 hydrophobic
BMS-681 Y49 1.39x39 TM1 Van der Waals
BMS-681 Y49 1.39x39 TM1 polar (hydrogen bond)
BMS-681 W98 2.60x60 TM2 hydrophobic
BMS-681 W98 2.60x60 TM2 Van der Waals
BMS-681 T117 3.29x29 TM3 Van der Waals
BMS-681 Y120 3.32x32 TM3 hydrophobic
BMS-681 Y120 3.32x32 TM3 Van der Waals
BMS-681 C190 45.50x50 ECL2 Van der Waals
BMS-681 Q288 7.36x35 TM7 polar (hydrogen bond with backbone)
BMS-681 Q288 7.36x35 TM7 Van der Waals
BMS-681 V289 7.37x36 TM7 Van der Waals
BMS-681 E291 7.39x38 TM7 Van der Waals
BMS-681 T292 7.40x39 TM7 polar (hydrogen bond)
BMS-681 M295 7.43x42 TM7 Van der Waals
BMS-681 M295 7.43x42 TM7 hydrophobic

Ligands

BMS-681

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Residue Diagrams

M N G V F G F I F V L S Y L P P L L Q A 1 L N L A I S D L L F L I T L P L W A H S 2 L I I F F I G G F Y G I H Y L G T F L K 3 G V V T S V I T W L V A V F A S V P G 4 Y C I V M I L L P L V L G L I N R M I T H 5 F T I M I V Y F L F W T P Y N I V I L L 6 I P N I C C H T M G L T E T V Q T A Q 7
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ICL1 K K L K ICL1ECL1 E W V F ECL1ICL2 A V F A L K A R ICL2ECL2 K C Q K E D S V Y V C G P Y F ECL2ICL3 R ICL3ECL3 L S N C ECL3N-term M L S T S R S R F I R N T N E S G E E V T T F F D Y D Y G A P C H K F D N-termC-term G C R I A P L Q K P V C G G P G V R P G K N V K V T T Q G L L D G R G K G K S I G R A P E A S L Q D K E G A C-term V K Q I G A Q L L P P L Y S L V F I F G F V G N M L V V L I L I N C C L T D I Y L L N L A I S D L L F L I T L P L W A H S A A N G N A M C K L F T G L Y H I G Y F G G I F F I I L L T I D R Y L A I V H T V T F G V V T S V I T W L V A V F A S V P G I I F T P R G W N N F H T I M R N I L G L V L P L L I M V I C Y S G I L K T L L R C N E K K R H R A V R V I F T I M I V Y F L F W T P Y N I V I L L N T F Q E F F G E S T S Q L D Q A T Q V T E T L G M T H C C I N P I I Y A F V G E K F H I F R S L A L
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Residue Table


GPCRdb(A)
GPCRdb(A)
CCR2
TM1
1x27 1.27x27 V37
1x35 1.35x35 L45
1x39 1.39x39 Y49
TM2
2x60 2.60x60 W98
TM3
3x29 3.29x29 T117
3x32 3.32x32 Y120
ECL2
45x50 45.50x50 C190
TM7
7x35 7.36x35 Q288
7x36 7.37x36 V289
7x38 7.39x38 E291
7x39 7.40x39 T292
7x42 7.43x42 M295