Structure information

5-HT2B receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

5TUD

SPECIES

Homo sapiens

RESOLUTION

3.000

PREFERRED CHAIN

D

PUBLICATION DATE

July 26, 2017

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
Ergotamine D135 3.32x32 TM3 polar (charge-charge)
Ergotamine V136 3.33x33 TM3 hydrophobic
Ergotamine T140 3.37x37 TM3 polar (hydrogen bond)
Ergotamine V208 45.51x51 ECL2 hydrophobic
Ergotamine L209 45.52x52 ECL2 polar (hydrogen bond with backbone)
Ergotamine M218 5.39x40 TM5 hydrophobic
Ergotamine F340 6.51x51 TM6 hydrophobic
Ergotamine F341 6.52x52 TM6 aromatic (edge-to-face)
Ergotamine L347 6.58x58 TM6 hydrophobic
Ergotamine Q359 7.32x31 TM7 polar (hydrogen bond)

Ligands

Ergotamine

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Residue Diagrams

T N G G I T P I I V M L I L L A A W H L K 1 M S L A V A D L L V G F L V M P I A L L T 2 A C L H M I S A T S F L V D L F L W A P 3 A F I K I T V V W L I S I G I A I P V 4 Y T V I M I A L P T F F A A L S G F L M F 5 G I V F F L F L L M W C P F F I T N I T 6 L P N V G S S V Y G I W V F I E L L M 7
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ICL1 K K L Q ICL1ECL1 E A M W P L ECL1ICL2 P I Q A N Q Y N ICL2ECL2 I E T D V D N P N N I T C V L T K E R ECL2ICL3 P Q R L T W L T V S T V F Q R D E T P C S S P E K V A M L D G S R K D K A L P N S G D E T L M R R T S T I G K K S ICL3ECL3 D S C ECL3N-term M A L S Y R V S E L Q S T I P E H I L Q S T F V H V I S S N W S G L Q T E S I P E E M K Q I V E E Q G N N-termC-term T C N Y R A T K S V K T L R K R S S K I Y F R N P M A E N S K F F K K H G I R N G I N P A M Y Q S P M R L R S S T I Q S S S I I L L D T L L L T E N E G D K T E E Q V S Y V C-term K L H W A A L L I L M V I I P T I G G N T L V I L A V S L E Y A T N Y F L M S L A V A D L L V G L F V M P I A L L T I M F P L V L C P A W L F L D V L F S T A S I M H L C A I S V D R Y I A I K K S R A T A F I K I T V V W L I S I G I A I P V P I K G F G D F M L F G S L A A F F T P L A I M I V T Y F L T I H A L Q K K A Y L V K N K P V Q T I S N E Q R A S K V L G I V F F L F L L M W C P F F I T N I T L V L C N Q T T L Q M L L E I F V W I G Y V S S G V N P L V Y T L F N K T F G R F R D A Y I
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Residue Table


GPCRdb(A)
GPCRdb(A)
5-HT2B receptor
TM3
3x32 3.32x32 D135
3x33 3.33x33 V136
3x37 3.37x37 T140
ECL2
45x51 45.51x51 V208
45x52 45.52x52 L209
TM5
5x40 5.39x40 M218
TM6
6x51 6.51x51 F340
6x52 6.52x52 F341
6x58 6.58x58 L347
TM7
7x31 7.32x31 Q359