Structure information

apelin receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

5VBL

SPECIES

Homo sapiens

RESOLUTION

2.600

PREFERRED CHAIN

B

REFERENCE

10.1016/J.STR.2017.04.008

PUBLICATION DATE

May 31, 2017

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
AMG3054 Y21 N-term polar (hydrogen bond with backbone)
AMG3054 Y21 N-term Van der Waals
AMG3054 T22 N-term Van der Waals
AMG3054 D23 N-term polar (hydrogen bond with backbone)
AMG3054 D23 N-term polar (charge-assisted hydrogen bond)
AMG3054 W24 N-term Van der Waals
AMG3054 W24 N-term hydrophobic
AMG3054 W85 2.60x60 TM2 Van der Waals
AMG3054 W85 2.60x60 TM2 hydrophobic
AMG3054 Y88 2.63x63 TM2 hydrophobic
AMG3054 R91 2.66x66 TM2 Van der Waals
AMG3054 Y93 ECL1 hydrophobic
AMG3054 Y93 ECL1 Van der Waals
AMG3054 R168 4.64x65 TM4 Van der Waals
AMG3054 L173 ECL2 Van der Waals
AMG3054 L173 ECL2 hydrophobic
AMG3054 E174 ECL2 Van der Waals
AMG3054 N175 ECL2 Van der Waals
AMG3054 N175 ECL2 polar (hydrogen bond with backbone)
AMG3054 T176 ECL2 polar (hydrogen bond)
AMG3054 T176 ECL2 Van der Waals
AMG3054 N177 ECL2 Van der Waals
AMG3054 N177 ECL2 polar (hydrogen bond with backbone)
AMG3054 Y185 ECL2 Van der Waals
AMG3054 Y185 ECL2 hydrophobic
AMG3054 E198 5.35x36 TM5 Van der Waals
AMG3054 Y264 6.51x51 TM6 Van der Waals
AMG3054 Y264 6.51x51 TM6 polar (hydrogen bond)
AMG3054 K268 6.55x55 TM6 polar (charge-assisted hydrogen bond)
AMG3054 Y271 6.58x58 TM6 polar (hydrogen bond)
AMG3054 Y271 6.58x58 TM6 Van der Waals
AMG3054 F291 7.35x34 TM7 hydrophobic
AMG3054 F291 7.35x34 TM7 Van der Waals
AMG3054 T295 7.39x38 TM7 Van der Waals
AMG3054 Y299 7.43x42 TM7 hydrophobic
AMG3054 Y299 7.43x42 TM7 Van der Waals

Ligands

AMG3054

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Residue Diagrams

G N G T T G L L F V L M Y I A P I L A 1 A S L A V A D L T F V V T L P L W A T Y 2 G T L C F V S A Y M N V F I L Y S S L K 3 G A V A T A V L W V L A A L L A M P V 4 Y C T L M I T F P V V F G V T T S S V G L 5 V V L V V T F A L C W M P Y H L V K T L 6 F P N L C S N V Y S I C T C Y P F I N 7
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ICL1 S R E K R ICL1ECL1 Y D W P F ECL1ICL2 P V A N A R L R ICL2ECL2 T T G D L E N T T K V Q C Y M D Y S M V A T V S ECL2ICL3 R K E ICL3ECL3 L H W ECL3N-term M E E G G D F D N Y Y G A D N Q S E C E Y T D W K S S G N-termC-term Q S R C A G T S H S S S G E K S A S Y S S G H S Q G P G P N M G K G G E Q M H E K S I P Y S Q E T L V V D C-term A L I P A I Y M L V F L L G T T G N G L V L W T V F R S R S A D I F I A S L A V A D L T F V V T L P L W A T Y T Y R D G T F F C K L S S Y L I F V N M Y A S V F C L T G L S F D R Y L A I V R L R V S G A V A T A V L W V L A A L L A M P V M V L R S E W A W E V G L G V S S T T V G F V V P F T I M L T C Y F F I A Q T I A G H F R I E G L R K R R R L L S I I V V L V V T F A L C W M P Y H L V K T L Y M L G S L P C D F D L F L M N I F P Y C T C I S Y V N S C L N P F L Y A F F D P R C T S G F R Q A M L C C
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Residue Table


GPCRdb(A)
GPCRdb(A)
apelin receptor
TM2
2x60 2.60x60 W85
2x63 2.63x63 Y88
2x66 2.66x66 R91
TM4
4x65 4.64x65 R168
TM5
5x36 5.35x36 E198
TM6
6x51 6.51x51 Y264
6x55 6.55x55 K268
6x58 6.58x58 Y271
TM7
7x34 7.35x34 F291
7x38 7.39x38 T295
7x42 7.43x42 Y299