PDB
5VEX
Resolution
3.0 Å
Released
May 17, 2017
Receptor
GLP-1
Class
B1
Species
Homo sapiens
Ligand
NNC0640
Function
NAM
Reference
10.1038/NATURE22378

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Ligand Amino Acid Generic Number Segment Interaction Type
NNC0640 R348 6.37x37 TM6 Van der Waals
NNC0640 R348 6.37x37 TM6 polar (hydrogen bond with backbone)
NNC0640 K351 6.40x40 TM6 Van der Waals
NNC0640 S352 6.41x41 TM6 polar (hydrogen bond)
NNC0640 S352 6.41x41 TM6 polar (hydrogen bond)
NNC0640 L354 6.43x43 TM6 hydrophobic
NNC0640 L354 6.43x43 TM6 Van der Waals
NNC0640 T355 6.44x44 TM6 Van der Waals
NNC0640 T355 6.44x44 TM6 polar (hydrogen bond)
NNC0640 M397 7.52x52 TM7 Van der Waals
NNC0640 L401 7.56x56 TM7 polar (hydrogen bond with backbone)
NNC0640 L401 7.56x56 TM7 Van der Waals
NNC0640 V405 7.60x60 TM7 polar (hydrogen bond with backbone)
NNC0640 V405 7.60x60 TM7 Van der Waals
NNC0640 N406 8.47x47 H8 polar (hydrogen bond)
NNC0640 N406 8.47x47 H8 Van der Waals
NNC0640 N407 8.48x48 H8 Van der Waals

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ICL1 R H L H ICL1ECL1 T A A Q Q H Q W D G L L S Y Q D S ECL1ICL2 S V L ICL2ECL2 D E G C W T R N S ECL2ICL3 M ICL3ECL3 D E H A R ECL3N-term M A G A P G P L R L A L L L L G M V G R A G P R P Q G A T V S L W E T V Q K W R E Y R R Q C Q R S L T E D P P P A T D L F C N R T F D E Y A C W P D G E P G S F V N V S C P W Y L P W A S S V P Q G H V Y R F C T A E G L W L Q K D N S S L P W R D L S E C E E S K R G E R S S P N-termC-term S M K P L K C P T S S L S S G A T A G S S M Y T A T C Q A S C S C-term E E Q L L F L Y I I Y T V G Y A L S F S A L V I A S A I L L G F C T R N Y I H L N L F A S F I L R A L S V F I K D A A L K W M Y S L S C R L V F L L M Q Y C V A A N Y Y W L L V E G V Y L Y T L L A F S E Q W I F R L Y V S I G W G V P L L F V V P W G I V K Y L Y E N M N Y W L I I R L P I L F A I G V N F L I F V R V I C I V V S K L K A N L C K T D I K C R L A K S T L T L I P L L G T H E V I F A F V M G T L R F I K L F T E L S F T S F Q G L M V A I L Y C F V N N E F R K W R L I Q R V Q L E S W E R E H L H D S
Helix box plot — Download: PNG | SVG V L A S F S L A Y G V T Y I I Y L F L L 1 L N L F A S F I L R A L S V F I K D A A 2 V L L W Y Y N A A V C Y Q M L L F V L R 3 I F R L Y V S G I W G V P L L F V V P W G 4 F I L F N V G I A F L I P L R I I L W Y N 5 L T L I P L L G T H E V I F A F V M 6 I A V M L G Q F S T F S L E T F L K I 7

GPCRdb(A)
GPCRdb(B)
GLP-1 receptor
TM6
6x32 6.37x37 R348
6x35 6.40x40 K351
6x36 6.41x41 S352
6x38 6.43x43 L354
6x39 6.44x44 T355
TM7
7x48 7.52x52 M397
7x52 7.56x56 L401
7x56 7.60x60 V405
H8
8x47 8.47x47 N406
8x48 8.48x48 N407