Structure information

D4 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

5WIU

SPECIES

Homo sapiens

RESOLUTION

1.960

PREFERRED CHAIN

A

PUBLICATION DATE

Oct. 18, 2017

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
Nemonapride F91 2.61x60 TM2 aromatic (edge-to-face)
Nemonapride D115 3.32x32 TM3 polar (charge-assisted hydrogen bond)
Nemonapride D115 3.32x32 TM3 polar (charge-assisted hydrogen bond)
Nemonapride D115 3.32x32 TM3 polar (charge-charge)
Nemonapride V116 3.33x33 TM3 hydrophobic
Nemonapride C119 3.36x36 TM3 hydrophobic
Nemonapride L187 45.52x52 ECL2 hydrophobic
Nemonapride S196 5.42x43 TM5 polar (hydrogen bond)
Nemonapride F410 6.51x51 TM6 aromatic (edge-to-face)
Nemonapride F411 6.52x52 TM6 hydrophobic

Ligands

Nemonapride

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Residue Diagrams

S N G A L V A G I L L V G G V L A A A G 1 V S L A A A D L L L A L L V L P L F V Y S 2 A C L N F I S A T C L M V D M A M L A D 3 Q L L L I G A T W L L S A A V A A P V 4 Y L L L M L P C P L F F S C V S S Y V V Y 5 P V V V G A F L L C W T P F F V V H I T 6 V P N L A S N V Y G L W T V A S V L R 7
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ICL1 R A L Q ICL1ECL1 G A W L L ECL1ICL2 P L R Y N R Q G ICL2ECL2 L N D V R G R D P A V C R L E ECL2ICL3 L H G R A P R R P S G P G P P S P T P P A P R L P Q D P C G P D C A P P A P G L P R G P C G P D C A P A A P G L P P D P C G P D C A P P A P G L P Q D P C G P D C A P P A P G L P R G P C G P D C A P P A P G L P Q D P C G P D C A P P A P G L P P D P C G S N C A P P D A V R A A A L P P Q T P P Q T R R R R R ICL3ECL3 P A C S V ECL3N-term M G N R S T A D A D G L L A G R G P A A G A S A G A S A G L N-termC-term A C C C-term A G Q G A A A L V G G V L L I G A V L A G N S L V C V S V A T E T P T N S F I V S L A A A D L L L A L L V L P L F V Y S E V Q G S P R L C D A L M A M D V M L C T A S I F N L C A I S V D R F V A V A V G S R R Q L L L I G A T W L L S A A V A A P V L C G D R D Y V V Y S S V C S F F L P C P L M L L L Y W A T F R G L Q R W E V A R R A K A K I T G R E R K A M R V L P V V V G A F L L C W T P F F V V H I T Q A L C P P R L V S A V T W L G Y V N S A L N P V I Y T V F N A E F R K F R N V A L R
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Residue Table


GPCRdb(A)
GPCRdb(A)
D4 receptor
TM2
2x60 2.61x60 F91
TM3
3x32 3.32x32 D115
3x33 3.33x33 V116
3x36 3.36x36 C119
ECL2
45x52 45.52x52 L187
TM5
5x43 5.42x43 S196
TM6
6x51 6.51x51 F410
6x52 6.52x52 F411