PDB
5XF1
Resolution
3.2 Å
Released
May 24, 2017
Receptor
glucagon
Class
B1
Species
Homo sapiens
Ligands
Antibody mAb1 (chain C)
Antibody mAb1 (chain D)
NNC0640
Function
Antagonist
Antagonist
NAM
Reference
10.1038/NATURE22363
Antibody mAb1 (chain C) Antibody mAb1 (chain D) NNC0640

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Ligand Amino Acid Generic Number Segment Interaction Type
Antibody mAb1 (chain C) L32 N-term hydrophobic
Antibody mAb1 (chain C) W36 N-term hydrophobic
Antibody mAb1 (chain C) K64 N-term Van der Waals
Antibody mAb1 (chain C) K64 N-term polar (hydrogen bond with backbone)
Antibody mAb1 (chain C) Y65 N-term hydrophobic
Antibody mAb1 (chain C) Y65 N-term Van der Waals
Antibody mAb1 (chain C) Y84 N-term Van der Waals
Antibody mAb1 (chain C) W87 N-term Van der Waals
Antibody mAb1 (chain C) W87 N-term hydrophobic
Antibody mAb1 (chain C) R108 N-term polar (charge-assisted hydrogen bond)
Antibody mAb1 (chain D) P110 N-term polar (hydrogen bond with backbone)
Antibody mAb1 (chain D) P110 N-term Van der Waals
Antibody mAb1 (chain D) R111 N-term polar (hydrogen bond with backbone)
Antibody mAb1 (chain C) R111 N-term polar (charge-assisted hydrogen bond)
Antibody mAb1 (chain D) R111 N-term polar (charge-assisted hydrogen bond)
Antibody mAb1 (chain C) G112 N-term Van der Waals
Antibody mAb1 (chain C) Q113 N-term Van der Waals
Antibody mAb1 (chain C) R116 N-term polar (charge-assisted hydrogen bond)
Antibody mAb1 (chain C) Q122 N-term Van der Waals
Antibody mAb1 (chain C) E127 N-term polar (charge-assisted hydrogen bond)
Antibody mAb1 (chain C) Q204 ECL1 polar (hydrogen bond)
Antibody mAb1 (chain C) Q204 ECL1 Van der Waals
Antibody mAb1 (chain C) Q204 ECL1 polar (hydrogen bond)
Antibody mAb1 (chain C) K205 ECL1 Van der Waals
Antibody mAb1 (chain C) I206 ECL1 Van der Waals
Antibody mAb1 (chain C) I206 ECL1 hydrophobic
Antibody mAb1 (chain C) G207 ECL1 Van der Waals
Antibody mAb1 (chain C) G207 ECL1 polar (hydrogen bond with backbone)
Antibody mAb1 (chain D) D208 ECL1 polar (charge-assisted hydrogen bond)
NNC0640 R346 6.37x37 TM6 polar (hydrogen bond with backbone)
NNC0640 R346 6.37x37 TM6 Van der Waals
NNC0640 L347 6.38x38 TM6 Van der Waals
NNC0640 K349 6.40x40 TM6 Van der Waals
NNC0640 S350 6.41x41 TM6 polar (hydrogen bond)
NNC0640 S350 6.41x41 TM6 Van der Waals
NNC0640 T353 6.44x44 TM6 polar (hydrogen bond)
NNC0640 T353 6.44x44 TM6 Van der Waals
NNC0640 L395 7.52x52 TM7 Van der Waals
NNC0640 L395 7.52x52 TM7 hydrophobic
NNC0640 L399 7.56x56 TM7 polar (hydrogen bond with backbone)
NNC0640 L399 7.56x56 TM7 Van der Waals
NNC0640 Y400 7.57x57 TM7 Van der Waals
NNC0640 L403 7.60x60 TM7 Van der Waals
NNC0640 L403 7.60x60 TM7 polar (hydrogen bond with backbone)
NNC0640 N404 8.47x47 H8 polar (hydrogen bond)
NNC0640 N404 8.47x47 H8 polar (hydrogen bond)

NGL is a WebGL based 3D viewer powered by MMTF.

Download PDB file

NGL is a WebGL based 3D viewer powered by MMTF.

Download PDB file

NGL is a WebGL based 3D viewer powered by MMTF.

Download PDB file

Snake plot — Download: PNG | SVG
ICL1 S K L H ICL1ECL1 Q K I G D D L S V S T W L S D G ECL1ICL2 A T L P E R ICL2ECL2 N V Q C W T S N D N M G F ECL2ICL3 R Q M H H T ICL3ECL3 E H A Q ECL3N-term M P P C Q P Q R P L L L L L L L L A C Q P Q V P S A Q V M D F L F E K W K L Y G D Q C H H N L S L L P P P T E L V C N R T F D K Y S C W P D T P A N T T A N I S C P W Y L P W H H K V Q H R F V F K R C G P D G Q W V R G P R G Q P W R D A S Q C Q M D G E E I E V N-termC-term T S N H R A S S S P G H G P P S K E L Q F G R G G G S Q D S S A E T P L A G G L P R L A E S P F C-term Q K E V A K M Y S S F Q V M Y T V G Y S L S L G A L L L A L A I L G G L C T R N A I H A N L F A S F V L K A S S V L V I D G L L R T R Y S A V A G C R V A A V F M Q Y G I V A N Y C W L L V E G L Y L H N L L G L S F F S L Y L G I G W G A P M L F V V P W A V V K C L F E W W I L R F P V F L A I L I N F F I F V R I V Q L L V A K L R A D Y K F R L A K S T L T L I P L L G V H E V V F A F V T D G T L R S A K L F F D L F L S S F Q G L L V A V L Y C F L N K E L R R W R L W E E V Q S E R W H R G K V L R N
Helix box plot — Download: PNG | SVG L L A G L S L S Y G V T Y M V Q F S S Y 1 A N L F A S F V L K A S S V L V I D G L 2 V L L W C Y N A V I G Y Q M F V A A V R 3 F F S L Y L G G I W G A P M L F V V P W A 4 F I F F N I L I A L F V P F R L I W W 5 L T L I P L L G V H E V V F A F V T D 6 V A V L L G Q F S S L F L D F F L K A 7

GPCRdb(A)
GPCRdb(B)
glucagon receptor
TM6
6x32 6.37x37 R346
6x33 6.38x38 L347
6x35 6.40x40 K349
6x36 6.41x41 S350
6x39 6.44x44 T353
TM7
7x48 7.52x52 L395
7x52 7.56x56 L399
7x53 7.57x57 Y400
7x56 7.60x60 L403
H8
8x47 8.47x47 N404