Structure information

EP4 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

5YHL

SPECIES

Homo sapiens

RESOLUTION

4.200

PREFERRED CHAIN

A

REFERENCE

10.1038/S41589-018-0131-3

PUBLICATION DATE

Dec. 5, 2018

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
ONO-AE3-208-Br I23 1.38x38 TM1 hydrophobic
ONO-AE3-208-Br P24 1.39x39 TM1 hydrophobic
ONO-AE3-208-Br T76 2.61x61 TM2 polar (hydrogen bond)
ONO-AE3-208-Br T76 2.61x61 TM2 Van der Waals
ONO-AE3-208-Br Y80 2.65x65 TM2 polar (hydrogen bond)
ONO-AE3-208-Br Y80 2.65x65 TM2 polar (hydrogen bond)
ONO-AE3-208-Br L99 3.32x32 TM3 Van der Waals
ONO-AE3-208-Br W169 ECL2 Van der Waals
ONO-AE3-208-Br W169 ECL2 hydrophobic
ONO-AE3-208-Br L312 7.36x35 TM7 Van der Waals
ONO-AE3-208-Br L312 7.36x35 TM7 hydrophobic
ONO-AE3-208-Br I315 7.39x38 TM7 Van der Waals
ONO-AE3-208-Br I315 7.39x38 TM7 hydrophobic
ONO-AE3-208-Br R316 7.40x39 TM7 polar (charge-assisted hydrogen bond)
ONO-AE3-208-Br S319 7.43x42 TM7 Van der Waals

Ligands

ONO-AE3-208-Br

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Residue Diagrams

L N G V V G F I F M V A P I T V P S N 1 C G L A V T D L L G T L L V S P V T I A 2 A C I I S L G S L S F F L L I F T S Y E 3 A G L T L F A V Y A S N V L F C A L P N 4 N C L V T A L I L F S S F G A Y M Y S Y 5 I A T S L V V L I C S I P L V V R V F V 6 W P D L I P N V S A I R I A Q L D P N 7
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ICL1 R K E Q K E ICL1ECL1 G Q W P G ECL1ICL2 A Y F Y S H Y V ICL2ECL2 L G S S R L Q Y P D T W C F I D W T T N ECL2ICL3 S L G T E Q H H A A A A A S V A S R G H P A A S P A L P R L S D F R R R R S F ICL3ECL3 Q P S L E R E V S K ECL3N-term M S T P G V N S S A S L S P D R L N-termC-term L F C R I G G S R R E R S G Q H C S D S Q R T S S A M S G H S R S F I S R E L K E I S S T S Q T L L P D L S L P D L S E N G L G G R N L L P G V P G M G L A Q E D T T S L R T L R I S E T S D S S Q G Q D S E S V L L V D E A G G S G R A G P A P K G S S L Q V T F P S E T L N L S E K C I C-term N S P V T I P A V M F I F G V V G N L V A I V V L C K S T T F Y T L V C G L A V T D L L G T L L V S P V T I A T Y M K G Q P L C E Y S T F I L L F F S L S G L S I I C A M S V E R Y L A I N H D K R L A G L T L F A V Y A S N V L F C A L P N M G V T A H A A Y S Y M Y A G F S S F L I L A T V L C N V L V C G A L L R M H R Q F M R R T R R I A G A E I Q M V I L L I A T S L V V L I C S I P L V V R V F V N Q L Y N P D L Q A I R I A S V N P I L D P W I Y I L L R K T A I E V L S K K I K C
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Residue Table


GPCRdb(A)
GPCRdb(A)
EP4 receptor
TM1
1x38 1.38x38 I23
1x39 1.39x39 P24
TM2
2x61 2.61x61 T76
2x65 2.65x65 Y80
TM3
3x32 3.32x32 L99
TM7
7x35 7.36x35 L312
7x38 7.39x38 I315
7x39 7.40x39 R316
7x42 7.43x42 S319