Structure information

glucagon receptor

PROTEIN CLASS

Class B1 (Secretin)

PDB CODE

5YQZ

SPECIES

Homo sapiens

RESOLUTION

3.000

PREFERRED CHAIN

R

REFERENCE

10.1038/NATURE25153

PUBLICATION DATE

Jan. 17, 2018

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
NNC1702 Q27 N-term Van der Waals
NNC1702 Q27 N-term polar (hydrogen bond with backbone)
NNC1702 V28 N-term polar (hydrogen bond with backbone)
NNC1702 V28 N-term Van der Waals
NNC1702 M29 N-term polar (hydrogen bond with backbone)
NNC1702 M29 N-term Van der Waals
NNC1702 L32 N-term Van der Waals
NNC1702 L32 N-term hydrophobic
NNC1702 F33 N-term Van der Waals
NNC1702 F33 N-term aromatic (edge-to-face)
NNC1702 W36 N-term aromatic (face-to-edge)
NNC1702 W36 N-term Van der Waals
NNC1702 K64 N-term polar (charge-assisted hydrogen bond)
NNC1702 Y65 N-term hydrophobic
NNC1702 Y65 N-term Van der Waals
NNC1702 Y84 N-term Van der Waals
NNC1702 L85 N-term hydrophobic
NNC1702 L85 N-term Van der Waals
NNC1702 W87 N-term Van der Waals
NNC1702 W87 N-term hydrophobic
NNC1702 P114 N-term Van der Waals
NNC1702 R116 N-term polar (charge-assisted hydrogen bond)
NNC1702 M123 N-term polar (hydrogen bond)
NNC1702 Q131 1.29x29 TM1 polar (hydrogen bond)
NNC1702 Q131 1.29x29 TM1 polar (hydrogen bond)
NNC1702 V134 1.32x32 TM1 Van der Waals
NNC1702 A135 1.33x33 TM1 Van der Waals
NNC1702 Y138 1.36x36 TM1 aromatic (edge-to-face)
NNC1702 Y138 1.36x36 TM1 Van der Waals
NNC1702 F141 1.39x39 TM1 Van der Waals
NNC1702 F141 1.39x39 TM1 hydrophobic
NNC1702 Q142 1.40x40 TM1 Van der Waals
NNC1702 Y145 1.43x43 TM1 Van der Waals
NNC1702 Y145 1.43x43 TM1 aromatic (edge-to-face)
NNC1702 Y149 1.47x47 TM1 polar (hydrogen bond)
NNC1702 Y149 1.47x47 TM1 Van der Waals
NNC1702 V191 2.64x64 TM2 Van der Waals
NNC1702 V191 2.64x64 TM2 hydrophobic
NNC1702 D195 2.68x68 TM2 Van der Waals
NNC1702 L198 2.71x71 TM2 Van der Waals
NNC1702 L198 2.71x71 TM2 hydrophobic
NNC1702 Y202 2.75x75 TM2 hydrophobic
NNC1702 Y202 2.75x75 TM2 Van der Waals
NNC1702 Q204 ECL1 Van der Waals
NNC1702 Q204 ECL1 polar (hydrogen bond with backbone)
NNC1702 K205 ECL1 Van der Waals
NNC1702 I206 ECL1 hydrophobic
NNC1702 I206 ECL1 Van der Waals
NNC1702 G207 ECL1 polar (hydrogen bond with backbone)
NNC1702 G207 ECL1 Van der Waals
NNC1702 D208 ECL1 Van der Waals
NNC1702 D209 ECL1 Van der Waals
NNC1702 V212 ECL1 hydrophobic
NNC1702 V212 ECL1 Van der Waals
NNC1702 W215 ECL1 hydrophobic
NNC1702 W215 ECL1 Van der Waals
NNC1702 Q293 ECL2 polar (hydrogen bond)
NNC1702 Q293 ECL2 polar (hydrogen bond)
NNC1702 T296 45.52x52 ECL2 Van der Waals
NNC1702 T296 45.52x52 ECL2 polar (hydrogen bond)
NNC1702 S297 ECL2 Van der Waals
NNC1702 N298 ECL2 Van der Waals
NNC1702 T369 6.60x60 TM6 Van der Waals
NNC1702 Q374 ECL3 polar (hydrogen bond)
NNC1702 Q374 ECL3 Van der Waals
NNC1702 R378 7.35x34 TM7 polar (charge-assisted hydrogen bond)
NNC1702 S379 7.36x35 TM7 Van der Waals
NNC1702 L382 7.39x38 TM7 hydrophobic
NNC1702 L382 7.39x38 TM7 Van der Waals
NNC1702 F383 7.40x39 TM7 Van der Waals
NNC1702 F383 7.40x39 TM7 hydrophobic
NNC1702 D385 7.42x41 TM7 polar (charge-assisted hydrogen bond)
NNC1702 L386 7.43x42 TM7 hydrophobic
NNC1702 L386 7.43x42 TM7 Van der Waals

Ligands

NNC1702

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Residue Diagrams

L L A G L S L S Y G V T Y M V Q F S S Y 1 A N L F A S F V L K A S S V L V I D G L 2 V L L W C Y N A V I G Y Q M F V A A V R 3 F F S L Y L G G I W G A P M L F V V P W A 4 F I F F N I L I A L F V P F R L I W W 5 L T L I P L L G V H E V V F A F V T D 6 V A V L L G Q F S S L F L D F F L K A 7
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ICL1 S K L H ICL1ECL1 Q K I G D D L S V S T W L S D G ECL1ICL2 A T L P E R ICL2ECL2 N V Q C W T S N D N M G F ECL2ICL3 R Q M H H T ICL3ECL3 E H A Q ECL3N-term M P P C Q P Q R P L L L L L L L L A C Q P Q V P S A Q V M D F L F E K W K L Y G D Q C H H N L S L L P P P T E L V C N R T F D K Y S C W P D T P A N T T A N I S C P W Y L P W H H K V Q H R F V F K R C G P D G Q W V R G P R G Q P W R D A S Q C Q M D G E E I E V N-termC-term T S N H R A S S S P G H G P P S K E L Q F G R G G G S Q D S S A E T P L A G G L P R L A E S P F C-term Q K E V A K M Y S S F Q V M Y T V G Y S L S L G A L L L A L A I L G G L C T R N A I H A N L F A S F V L K A S S V L V I D G L L R T R Y S A V A G C R V A A V F M Q Y G I V A N Y C W L L V E G L Y L H N L L G L S F F S L Y L G I G W G A P M L F V V P W A V V K C L F E W W I L R F P V F L A I L I N F F I F V R I V Q L L V A K L R A D Y K F R L A K S T L T L I P L L G V H E V V F A F V T D G T L R S A K L F F D L F L S S F Q G L L V A V L Y C F L N K E L R R W R L W E E V Q S E R W H R G K V L R N
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Residue Table


GPCRdb(A)
GPCRdb(B)
glucagon receptor
TM1
1x25 1.29x29 Q131
1x28 1.32x32 V134
1x29 1.33x33 A135
1x32 1.36x36 Y138
1x35 1.39x39 F141
1x36 1.40x40 Q142
1x39 1.43x43 Y145
1x43 1.47x47 Y149
TM2
2x57 2.64x64 V191
2x61 2.68x68 D195
2x64 2.71x71 L198
2x68 2.75x75 Y202
ECL2
45x52 45.52x52 T296
TM6
6x55 6.60x60 T369
TM7
7x30 7.35x34 R378
7x31 7.36x35 S379
7x34 7.39x38 L382
7x35 7.40x39 F383
7x37 7.42x41 D385
7x38 7.43x42 L386