Structure information

M2 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

5ZKB

SPECIES

Homo sapiens

RESOLUTION

2.950

PREFERRED CHAIN

A

PUBLICATION DATE

Nov. 21, 2018

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
AF-DX 384 D103 3.32x32 TM3 polar (charge-charge)
AF-DX 384 D103 3.32x32 TM3 polar (charge-charge)
AF-DX 384 Y104 3.33x33 TM3 polar (hydrogen bond)
AF-DX 384 Y104 3.33x33 TM3 polar (hydrogen bond)
AF-DX 384 S107 3.36x36 TM3 polar (hydrogen bond)
AF-DX 384 A194 5.46x461 TM5 hydrophobic
AF-DX 384 W400 6.48x48 TM6 hydrophobic
AF-DX 384 Y403 6.51x51 TM6 polar (hydrogen bond)
AF-DX 384 N404 6.52x52 TM6 polar (hydrogen bond)
AF-DX 384 N404 6.52x52 TM6 polar (hydrogen bond)
AF-DX 384 Y426 7.39x38 TM7 hydrophobic
AF-DX 384 Y430 7.43x42 TM7 hydrophobic

Ligands

AF-DX 384

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Residue Diagrams

I N G I I T V L S L S G A V L V I F V V 1 F S L A C A D L I I G F V S M N L Y T L Y 2 I L L N M V S A N S V V Y D L A L W L D 3 A G M M I A A A W V L S F I L W A P A I 4 Y L V T M I I V P L Y F A A I A T G F T V 5 L A I L L A F I I T W A P Y N V M V L I 6 A P N I T S N I Y C L W Y G I T W V T 7
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ICL1 R H L Q ICL1ECL1 Y W P L ECL1ICL2 P L T Y P V K R ICL2ECL2 V R T V E D G E C Y I Q F F S ECL2ICL3 P V A N Q D P V S P S L V Q G R I V K P N N N N M P S S D D G L E H N K I Q N G K A P R D P V T E N C V Q G E E K E S S N D S T S V S A V A S N M R D D E I T Q D E N T V S T S L G H S K D E N S K Q T C I R I G T K T P K S D S C T P T N T T V E V V G S S G Q N G D E K Q N I V A R K I V K M T K Q P A K K ICL3ECL3 A P C I ECL3N-term M N N S T N S S N N S L A L T S P Y N-termC-term C H Y K N I G A T R C-term K T F E V V F I V L V A G S L S L V T I I G N I L V M V S I K V N T V N N Y F L F S L A C A D L I I G V F S M N L Y T L Y T V I G G P V V C D L W L A L D Y V V S N A S V M N L L I I S F D R Y F C V T K T T K M A G M M I A A A W V L S F I L W A P A I L F W Q F I V G N A A V T F G T A I A A F Y L P V I I M T V L Y W H I S R A S K S R I K K D K K E K P P P S R E K K V T R T I L A I L L A F I I T W A P Y N V M V L I N T F C P N T V W T I G Y W L C Y I N S T I N P A C Y A L C N A T F K H F K K T L L M
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Residue Table


GPCRdb(A)
GPCRdb(A)
M2 receptor
TM3
3x32 3.32x32 D103
3x33 3.33x33 Y104
3x36 3.36x36 S107
TM5
5x461 5.46x461 A194
TM6
6x48 6.48x48 W400
6x51 6.51x51 Y403
6x52 6.52x52 N404
TM7
7x38 7.39x38 Y426
7x42 7.43x42 Y430