Structure information

5-HT2A receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

6A93

SPECIES

Homo sapiens

RESOLUTION

3.000

PREFERRED CHAIN

A

REFERENCE

10.1038/S41594-018-0180-Z

PUBLICATION DATE

Feb. 13, 2019

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
risperidone W151 3.28x28 TM3 hydrophobic
risperidone D155 3.32x32 TM3 polar (charge-assisted hydrogen bond)
risperidone V156 3.33x33 TM3 Van der Waals
risperidone S159 3.36x36 TM3 Van der Waals
risperidone T160 3.37x37 TM3 Van der Waals
risperidone I163 3.40x40 TM3 hydrophobic
risperidone I163 3.40x40 TM3 Van der Waals
risperidone L228 45.51x51 ECL2 Van der Waals
risperidone L228 45.51x51 ECL2 hydrophobic
risperidone S242 5.46x461 TM5 Van der Waals
risperidone F243 5.47x47 TM5 Van der Waals
risperidone F332 6.44x44 TM6 Van der Waals
risperidone F332 6.44x44 TM6 hydrophobic
risperidone W336 6.48x48 TM6 aromatic (face-to-edge)
risperidone W336 6.48x48 TM6 Van der Waals
risperidone F339 6.51x51 TM6 hydrophobic
risperidone F339 6.51x51 TM6 Van der Waals
risperidone F340 6.52x52 TM6 Van der Waals
risperidone F340 6.52x52 TM6 aromatic (edge-to-face)
risperidone L362 7.35x34 TM7 hydrophobic
risperidone L362 7.35x34 TM7 Van der Waals
risperidone V366 7.39x38 TM7 hydrophobic
risperidone V366 7.39x38 TM7 Van der Waals
risperidone Y370 7.43x42 TM7 hydrophobic
risperidone Y370 7.43x42 TM7 Van der Waals

Ligands

risperidone

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Residue Diagrams

I N G A I T L I I V V A T L L A S W N K 1 M S L A I A D M L L G L F V M P V S M L T 2 A C L H M I S A T S F L V D L Y I W V A 3 A F L K I I A V W T I S V G I S M P I 4 Y T I V M I T L P I F F S V F S G I L V F 5 G I V F F L F V V M W C P F F I T N I M 6 L P N V A S S L Y G I W V F V N L L A 7
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ICL1 K K L Q ICL1ECL1 Y R W P L ECL1ICL2 P I H H S R F N ICL2ECL2 D S K V F K E G S C L L A ECL2ICL3 G T R A K L A S F S F L P Q S S L S S E K L F Q R S I H R E P G S Y T G R R T ICL3ECL3 K E S C ECL3N-term M D I L C E E N T S L S S T T N S L M Q L N D D T R L Y S N D F N S G E A N T S D A F N W T V D S E N R T N L S C E G C L S P S C L S L N-termC-term Q Y K E N K K P L Q L I L V N T I P A L A Y K S S Q L Q M G Q K K N S K Q D A K T T D N D C S M V A L G K Q H S E E A S K D N S D G V N E K V S C V C-term L H L Q E K N W S A L L T A V V I I L T I A G N I L V I M A V S L E N A T N Y F L M S L A I A D M L L G F L V M P V S M L T I L Y G P S K L C A V W I Y L D V L F S T A S I M H L C A I S L D R Y V A I Q N S R T K A F L K I I A V W T I S V G I S M P I P V F G L Q D D D N F V L I G S F V S F F I P L T I M V I T Y F L T I K S L Q K E A T L C V S D L M Q S I S N E Q K A C K V L G I V F F L F V V M W C P F F I T N I M A V I C N E D V I G A L L N V F V W I G Y L S S A V N P L V Y T L F N K T F S R Y R S A Y I Q C
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Residue Table


GPCRdb(A)
GPCRdb(A)
5-HT2A receptor
TM3
3x28 3.28x28 W151
3x32 3.32x32 D155
3x33 3.33x33 V156
3x36 3.36x36 S159
3x37 3.37x37 T160
3x40 3.40x40 I163
ECL2
45x51 45.51x51 L228
TM5
5x461 5.46x461 S242
5x47 5.47x47 F243
TM6
6x44 6.44x44 F332
6x48 6.48x48 W336
6x51 6.51x51 F339
6x52 6.52x52 F340
TM7
7x34 7.35x34 L362
7x38 7.39x38 V366
7x42 7.43x42 Y370