Structure information

5-HT2C receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

6BQG

SPECIES

Homo sapiens

RESOLUTION

3.000

PREFERRED CHAIN

A

PUBLICATION DATE

Feb. 14, 2018

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
ergotamine D134 3.32x32 TM3 polar (charge-assisted hydrogen bond)
ergotamine V135 3.33x33 TM3 Van der Waals
ergotamine V135 3.33x33 TM3 hydrophobic
ergotamine S138 3.36x36 TM3 Van der Waals
ergotamine T139 3.37x37 TM3 polar (hydrogen bond)
ergotamine V208 45.51x51 ECL2 Van der Waals
ergotamine V208 45.51x51 ECL2 hydrophobic
ergotamine L209 45.52x52 ECL2 polar (hydrogen bond with backbone)
ergotamine L209 45.52x52 ECL2 Van der Waals
ergotamine F214 5.38x39 TM5 hydrophobic
ergotamine V215 5.39x40 TM5 hydrophobic
ergotamine V215 5.39x40 TM5 Van der Waals
ergotamine G218 5.42x43 TM5 Van der Waals
ergotamine S219 5.43x44 TM5 Van der Waals
ergotamine A222 5.46x461 TM5 Van der Waals
ergotamine F327 6.51x51 TM6 hydrophobic
ergotamine F327 6.51x51 TM6 Van der Waals
ergotamine F328 6.52x52 TM6 aromatic (edge-to-face)
ergotamine F328 6.52x52 TM6 Van der Waals
ergotamine N331 6.55x55 TM6 Van der Waals
ergotamine S334 6.58x58 TM6 Van der Waals
ergotamine V335 6.59x59 TM6 hydrophobic
ergotamine V335 6.59x59 TM6 Van der Waals
ergotamine E347 7.32x31 TM7 Van der Waals
ergotamine L350 7.35x34 TM7 hydrophobic
ergotamine L350 7.35x34 TM7 Van der Waals
ergotamine N351 7.36x35 TM7 Van der Waals
ergotamine V354 7.39x38 TM7 hydrophobic
ergotamine V354 7.39x38 TM7 Van der Waals
ergotamine Y358 7.43x42 TM7 hydrophobic
ergotamine Y358 7.43x42 TM7 Van der Waals

Ligands

ergotamine

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Residue Diagrams

I N G G I T M I I I I V I S L A P W N 1 M S L A I A D M L V G L L V M P L S L L A 2 A C L H M I S A T S F L V D L S I W V P 3 A I M K I A I V W A I S I G V S V P I 4 Y T I V M I T L P I F F A V F S G I L V F 5 G I V F F V F L I M W C P F F I T N I L 6 L P N I G S C V Y G I W V F V N L L K 7
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ICL1 K K L H ICL1ECL1 Y V W P L ECL1ICL2 P I E H S R F N ICL2ECL2 E E K V F V N N T T C V L N ECL2ICL3 G H T E E P P G L S L D F L K C C K R N T A E E E N S A N P N Q D Q N A R R R K K K E R R P R G T ICL3ECL3 E K S C ECL3N-term M V N L R N A V H S F L V H L I G L L V W Q S D I S V S P V A A I V T D I F N T S D G G R F K F P D G V Q N-termC-term N Y K V E K K P P V R Q I P R V A A T A L S G R E L N V N I Y R H T N E P V I E K A S D N E P G I E M Q V E N L E L P V N P S S V V S E R I S S V C-term N W P A L S I V I I I I M T I G G N I L V I M A V S M E N A T N Y F L M S L A I A D M L V G L L V M P L S L L A I L Y D P R Y L C P V W I S L D V L F S T A S I M H L C A I S L D R Y V A I R N S R T K A I M K I A I V W A I S I G V S V P I P V I G L R D D P N F V L I G S F V A F F I P L T I M V I T Y C L T I Y V L R R Q A L M L L H M Q A I N N E R K A S K V L G I V F F V F L I M W C P F F I T N I L S V L C N Q K L M E K L L N V F V W I G Y V C S G I N P L V Y T L F N K I F S N Y R R A Y L R C
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Residue Table


GPCRdb(A)
GPCRdb(A)
5-HT2C receptor
TM3
3x32 3.32x32 D134
3x33 3.33x33 V135
3x36 3.36x36 S138
3x37 3.37x37 T139
ECL2
45x51 45.51x51 V208
45x52 45.52x52 L209
TM5
5x39 5.38x39 F214
5x40 5.39x40 V215
5x43 5.42x43 G218
5x44 5.43x44 S219
5x461 5.46x461 A222
TM6
6x51 6.51x51 F327
6x52 6.52x52 F328
6x55 6.55x55 N331
6x58 6.58x58 S334
6x59 6.59x59 V335
TM7
7x31 7.32x31 E347
7x34 7.35x34 L350
7x35 7.36x35 N351
7x38 7.39x38 V354
7x42 7.43x42 Y358