Structure information

5-HT2C receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

6BQG

SPECIES

Homo sapiens

RESOLUTION

3.000

PREFERRED CHAIN

A

PUBLICATION DATE

Feb. 14, 2018

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
Ergotamine D134 3.32x32 TM3 polar (charge-charge)
Ergotamine V135 3.33x33 TM3 hydrophobic
Ergotamine T139 3.37x37 TM3 polar (hydrogen bond)
Ergotamine V208 45.51x51 ECL2 hydrophobic
Ergotamine L209 45.52x52 ECL2 polar (hydrogen bond with backbone)
Ergotamine V215 5.39x40 TM5 hydrophobic
Ergotamine F327 6.51x51 TM6 hydrophobic
Ergotamine F328 6.52x52 TM6 aromatic (edge-to-face)
Ergotamine V335 6.59x59 TM6 hydrophobic
Ergotamine L350 7.35x34 TM7 hydrophobic

Ligands

Ergotamine

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Residue Diagrams

I N G G I T M I I I I V I S L A P W N 1 M S L A I A D M L V G L L V M P L S L L A 2 A C L H M I S A T S F L V D L S I W V P 3 A I M K I A I V W A I S I G V S V P I 4 Y T I V M I T L P I F F A V F S G I L V F 5 G I V F F V F L I M W C P F F I T N I L 6 L P N I G S C V Y G I W V F V N L L K 7
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ICL1 K K L H ICL1ECL1 Y V W P L ECL1ICL2 P I E H S R F N ICL2ECL2 E E K V F V N N T T C V L N ECL2ICL3 G H T E E P P G L S L D F L K C C K R N T A E E E N S A N P N Q D Q N A R R R K K K E R R P R G T ICL3ECL3 E K S C ECL3N-term M V N L R N A V H S F L V H L I G L L V W Q C D I S V S P V A A I V T D I F N T S D G G R F K F P D G V Q N-termC-term N Y K V E K K P P V R Q I P R V A A T A L S G R E L N V N I Y R H T N E P V I E K A S D N E P G I E M Q V E N L E L P V N P S S V V S E R I S S V C-term N W P A L S I V I I I I M T I G G N I L V I M A V S M E N A T N Y F L M S L A I A D M L V G L L V M P L S L L A I L Y D P R Y L C P V W I S L D V L F S T A S I M H L C A I S L D R Y V A I R N S R T K A I M K I A I V W A I S I G V S V P I P V I G L R D D P N F V L I G S F V A F F I P L T I M V I T Y C L T I Y V L R R Q A L M L L H M Q A I N N E R K A S K V L G I V F F V F L I M W C P F F I T N I L S V L C N Q K L M E K L L N V F V W I G Y V C S G I N P L V Y T L F N K I F S N Y R R A Y L R C
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Residue Table


GPCRdb(A)
GPCRdb(A)
5-HT2C receptor
TM3
3x32 3.32x32 D134
3x33 3.33x33 V135
3x37 3.37x37 T139
ECL2
45x51 45.51x51 V208
45x52 45.52x52 L209
TM5
5x40 5.39x40 V215
TM6
6x51 6.51x51 F327
6x52 6.52x52 F328
6x59 6.59x59 V335
TM7
7x34 7.35x34 L350