Structure information

5-HT2C receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

6BQH

SPECIES

Homo sapiens

RESOLUTION

2.700

PREFERRED CHAIN

A

PUBLICATION DATE

Feb. 14, 2018

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
Ritanserin D134 3.32x32 TM3 polar (charge-charge)
Ritanserin V135 3.33x33 TM3 hydrophobic
Ritanserin S138 3.36x36 TM3 polar (hydrogen bond with backbone)
Ritanserin V208 45.51x51 ECL2 hydrophobic
Ritanserin G218 5.42x43 TM5 polar (hydrogen bond with backbone)
Ritanserin S219 5.43x44 TM5 polar (hydrogen bond with backbone)
Ritanserin A222 5.46x461 TM5 hydrophobic
Ritanserin F223 5.47x47 TM5 aromatic (edge-to-face)
Ritanserin W324 6.48x48 TM6 aromatic (face-to-edge)
Ritanserin F327 6.51x51 TM6 hydrophobic
Ritanserin F328 6.52x52 TM6 aromatic (edge-to-face)
Ritanserin N351 7.36x35 TM7 polar (hydrogen bond)
Ritanserin V354 7.39x38 TM7 hydrophobic

Ligands

Ritanserin

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Residue Diagrams

I N G G I T M I I I I V I S L A P W N 1 M S L A I A D M L V G L L V M P L S L L A 2 A C L H M I S A T S F L V D L S I W V P 3 A I M K I A I V W A I S I G V S V P I 4 Y T I V M I T L P I F F A V F S G I L V F 5 G I V F F V F L I M W C P F F I T N I L 6 L P N I G S C V Y G I W V F V N L L K 7
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ICL1 K K L H ICL1ECL1 Y V W P L ECL1ICL2 P I E H S R F N ICL2ECL2 E E K V F V N N T T C V L N ECL2ICL3 G H T E E P P G L S L D F L K C C K R N T A E E E N S A N P N Q D Q N A R R R K K K E R R P R G T ICL3ECL3 E K S C ECL3N-term M V N L R N A V H S F L V H L I G L L V W Q C D I S V S P V A A I V T D I F N T S D G G R F K F P D G V Q N-termC-term N Y K V E K K P P V R Q I P R V A A T A L S G R E L N V N I Y R H T N E P V I E K A S D N E P G I E M Q V E N L E L P V N P S S V V S E R I S S V C-term N W P A L S I V I I I I M T I G G N I L V I M A V S M E N A T N Y F L M S L A I A D M L V G L L V M P L S L L A I L Y D P R Y L C P V W I S L D V L F S T A S I M H L C A I S L D R Y V A I R N S R T K A I M K I A I V W A I S I G V S V P I P V I G L R D D P N F V L I G S F V A F F I P L T I M V I T Y C L T I Y V L R R Q A L M L L H M Q A I N N E R K A S K V L G I V F F V F L I M W C P F F I T N I L S V L C N Q K L M E K L L N V F V W I G Y V C S G I N P L V Y T L F N K I F S N Y R R A Y L R C
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Residue Table


GPCRdb(A)
GPCRdb(A)
5-HT2C receptor
TM3
3x32 3.32x32 D134
3x33 3.33x33 V135
3x36 3.36x36 S138
ECL2
45x51 45.51x51 V208
TM5
5x43 5.42x43 G218
5x44 5.43x44 S219
5x461 5.46x461 A222
5x47 5.47x47 F223
TM6
6x48 6.48x48 W324
6x51 6.51x51 F327
6x52 6.52x52 F328
TM7
7x35 7.36x35 N351
7x38 7.39x38 V354