Structure information

5-HT2B receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

6DRX

SPECIES

Homo sapiens

RESOLUTION

3.100

PREFERRED CHAIN

A

PUBLICATION DATE

Aug. 29, 2018

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
lisuride W131 3.28x28 TM3 hydrophobic
lisuride L132 3.29x29 TM3 hydrophobic
lisuride D135 3.32x32 TM3 polar (charge-assisted hydrogen bond)
lisuride V136 3.33x33 TM3 hydrophobic
lisuride V136 3.33x33 TM3 Van der Waals
lisuride S139 3.36x36 TM3 Van der Waals
lisuride T140 3.37x37 TM3 Van der Waals
lisuride V208 45.51x51 ECL2 hydrophobic
lisuride V208 45.51x51 ECL2 Van der Waals
lisuride L209 45.52x52 ECL2 hydrophobic
lisuride F217 5.38x39 TM5 Van der Waals
lisuride F217 5.38x39 TM5 aromatic (face-to-face)
lisuride G221 5.42x43 TM5 Van der Waals
lisuride S222 5.43x44 TM5 Van der Waals
lisuride W337 6.48x48 TM6 Van der Waals
lisuride F340 6.51x51 TM6 hydrophobic
lisuride F340 6.51x51 TM6 Van der Waals
lisuride F341 6.52x52 TM6 aromatic (edge-to-face)
lisuride F341 6.52x52 TM6 Van der Waals
lisuride N344 6.55x55 TM6 Van der Waals
lisuride V366 7.39x38 TM7 Van der Waals
lisuride V366 7.39x38 TM7 hydrophobic
lisuride Y370 7.43x42 TM7 Van der Waals

Ligands

lisuride

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Residue Diagrams

T N G G I T P I I V M L I L L A A W H L K 1 M S L A V A D L L V G F L V M P I A L L T 2 A C L H M I S A T S F L V D L F L W A P 3 A F I K I T V V W L I S I G I A I P V 4 Y T V I M I A L P T F F A A L S G F L M F 5 G I V F F L F L L M W C P F F I T N I T 6 L P N V G S S V Y G I W V F I E L L M 7
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ICL1 K K L Q ICL1ECL1 E A M W P L ECL1ICL2 P I Q A N Q Y N ICL2ECL2 I E T D V D N P N N I T C V L T K E R ECL2ICL3 P Q R L T W L T V S T V F Q R D E T P C S S P E K V A M L D G S R K D K A L P N S G D E T L M R R T S T I G K K S ICL3ECL3 D S C ECL3N-term M A L S Y R V S E L Q S T I P E H I L Q S T F V H V I S S N W S G L Q T E S I P E E M K Q I V E E Q G N N-termC-term T C N Y R A T K S V K T L R K R S S K I Y F R N P M A E N S K F F K K H G I R N G I N P A M Y Q S P M R L R S S T I Q S S S I I L L D T L L L T E N E G D K T E E Q V S Y V C-term K L H W A A L L I L M V I I P T I G G N T L V I L A V S L E Y A T N Y F L M S L A V A D L L V G L F V M P I A L L T I M F P L V L C P A W L F L D V L F S T A S I M H L C A I S V D R Y I A I K K S R A T A F I K I T V V W L I S I G I A I P V P I K G F G D F M L F G S L A A F F T P L A I M I V T Y F L T I H A L Q K K A Y L V K N K P V Q T I S N E Q R A S K V L G I V F F L F L L M W C P F F I T N I T L V L C N Q T T L Q M L L E I F V W I G Y V S S G V N P L V Y T L F N K T F G R F R D A Y I
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Residue Table


GPCRdb(A)
GPCRdb(A)
5-HT2B receptor
TM3
3x28 3.28x28 W131
3x29 3.29x29 L132
3x32 3.32x32 D135
3x33 3.33x33 V136
3x36 3.36x36 S139
3x37 3.37x37 T140
ECL2
45x51 45.51x51 V208
45x52 45.52x52 L209
TM5
5x39 5.38x39 F217
5x43 5.42x43 G221
5x44 5.43x44 S222
TM6
6x48 6.48x48 W337
6x51 6.51x51 F340
6x52 6.52x52 F341
6x55 6.55x55 N344
TM7
7x38 7.39x38 V366
7x42 7.43x42 Y370