Structure information

5-HT2B receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

6DRZ

SPECIES

Homo sapiens

RESOLUTION

3.100

PREFERRED CHAIN

A

PUBLICATION DATE

Aug. 29, 2018

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
methysergide D135 3.32x32 TM3 polar (charge-charge)
methysergide V136 3.33x33 TM3 hydrophobic
methysergide L209 45.52x52 ECL2 polar (hydrogen bond with backbone)
methysergide F217 5.38x39 TM5 hydrophobic
methysergide F340 6.51x51 TM6 hydrophobic
methysergide F341 6.52x52 TM6 aromatic (edge-to-face)
methysergide V366 7.39x38 TM7 hydrophobic

Ligands

methysergide

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Residue Diagrams

T N G G I T P I I V M L I L L A A W H L K 1 M S L A V A D L L V G F L V M P I A L L T 2 A C L H M I S A T S F L V D L F L W A P 3 A F I K I T V V W L I S I G I A I P V 4 Y T V I M I A L P T F F A A L S G F L M F 5 G I V F F L F L L M W C P F F I T N I T 6 L P N V G S S V Y G I W V F I E L L M 7
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ICL1 K K L Q ICL1ECL1 E A M W P L ECL1ICL2 P I Q A N Q Y N ICL2ECL2 I E T D V D N P N N I T C V L T K E R ECL2ICL3 P Q R L T W L T V S T V F Q R D E T P C S S P E K V A M L D G S R K D K A L P N S G D E T L M R R T S T I G K K S ICL3ECL3 D S C ECL3N-term M A L S Y R V S E L Q S T I P E H I L Q S T F V H V I S S N W S G L Q T E S I P E E M K Q I V E E Q G N N-termC-term T C N Y R A T K S V K T L R K R S S K I Y F R N P M A E N S K F F K K H G I R N G I N P A M Y Q S P M R L R S S T I Q S S S I I L L D T L L L T E N E G D K T E E Q V S Y V C-term K L H W A A L L I L M V I I P T I G G N T L V I L A V S L E Y A T N Y F L M S L A V A D L L V G L F V M P I A L L T I M F P L V L C P A W L F L D V L F S T A S I M H L C A I S V D R Y I A I K K S R A T A F I K I T V V W L I S I G I A I P V P I K G F G D F M L F G S L A A F F T P L A I M I V T Y F L T I H A L Q K K A Y L V K N K P V Q T I S N E Q R A S K V L G I V F F L F L L M W C P F F I T N I T L V L C N Q T T L Q M L L E I F V W I G Y V S S G V N P L V Y T L F N K T F G R F R D A Y I
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Residue Table


GPCRdb(A)
GPCRdb(A)
5-HT2B receptor
TM3
3x32 3.32x32 D135
3x33 3.33x33 V136
ECL2
45x52 45.52x52 L209
TM5
5x39 5.38x39 F217
TM6
6x51 6.51x51 F340
6x52 6.52x52 F341
TM7
7x38 7.39x38 V366