Structure information

calcitonin receptor-like receptor

PROTEIN CLASS

Class B1 (Secretin)

PDB CODE

6E3Y

SPECIES

Homo sapiens

RESOLUTION

3.300

PREFERRED CHAIN

R

PUBLICATION DATE

Sept. 19, 2018

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
Calcitonin gene-related peptide 1 W72 N-term hydrophobic
Calcitonin gene-related peptide 1 D90 N-term polar (charge-assisted hydrogen bond)
Calcitonin gene-related peptide 1 Q93 N-term polar (hydrogen bond with backbone)
Calcitonin gene-related peptide 1 D94 N-term polar (charge-assisted hydrogen bond)
Calcitonin gene-related peptide 1 D94 N-term polar (charge-assisted hydrogen bond)
Calcitonin gene-related peptide 1 F95 N-term hydrophobic
Calcitonin gene-related peptide 1 H114 N-term polar (hydrogen bond)
Calcitonin gene-related peptide 1 S117 N-term polar (hydrogen bond)
Calcitonin gene-related peptide 1 S117 N-term polar (hydrogen bond)
Calcitonin gene-related peptide 1 R119 N-term polar (charge-assisted hydrogen bond)
Calcitonin gene-related peptide 1 W121 N-term polar (hydrogen bond)
Calcitonin gene-related peptide 1 W121 N-term polar (hydrogen bond)
Calcitonin gene-related peptide 1 T122 N-term polar (hydrogen bond with backbone)
Calcitonin gene-related peptide 1 T122 N-term polar (hydrogen bond with backbone)
Calcitonin gene-related peptide 1 Y124 N-term hydrophobic
Calcitonin gene-related peptide 1 N128 N-term polar (hydrogen bond)
Calcitonin gene-related peptide 1 V135 1.33x33 TM1 hydrophobic
Calcitonin gene-related peptide 1 L139 1.37x37 TM1 hydrophobic
Calcitonin gene-related peptide 1 F142 1.40x40 TM1 hydrophobic
Calcitonin gene-related peptide 1 L195 2.68x68 TM2 hydrophobic
Calcitonin gene-related peptide 1 A199 ECL1 polar (hydrogen bond with backbone)
Calcitonin gene-related peptide 1 Q202 ECL1 polar (hydrogen bond)
Calcitonin gene-related peptide 1 M223 3.40x40 TM3 hydrophobic
Calcitonin gene-related peptide 1 I284 45.52x52 ECL2 hydrophobic
Calcitonin gene-related peptide 1 S286 ECL2 polar (hydrogen bond)
Calcitonin gene-related peptide 1 S286 ECL2 polar (hydrogen bond)
Calcitonin gene-related peptide 1 D287 ECL2 polar (hydrogen bond with backbone)
Calcitonin gene-related peptide 1 Y292 5.37x38 TM5 polar (hydrogen bond)
Calcitonin gene-related peptide 1 Y292 5.37x38 TM5 polar (hydrogen bond)
Calcitonin gene-related peptide 1 H295 5.40x40 TM5 polar (hydrogen bond)
Calcitonin gene-related peptide 1 H295 5.40x40 TM5 polar (hydrogen bond)
Calcitonin gene-related peptide 1 H295 5.40x40 TM5 aromatic (edge-to-face)
Calcitonin gene-related peptide 1 M373 7.46x45 TM7 hydrophobic

Ligands

Calcitonin gene-related peptide 1

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Residue Diagrams

L L S A I S L G H G I I T L Y F L N L A 1 K N L F F S F V C N S V V T I I H L T A 2 C L M W F Y N C G M L Y L H I F Q S V K 3 H L M W Y Y F G L W G F P L I P A C I H A 4 L F F L N V L L A A C I P G H I I Y L L H 5 L I L V P L L G I E F V L I P W 6 T S V L L G Q F H M L I H M I Y D Y V 7
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ICL1 K S L S ICL1ECL1 A N N Q A L V A T N P ECL1ICL2 A V F A E K Q ICL2ECL2 N D N C W I S S D ECL2ICL3 V T H Q A E S N L ICL3ECL3 R P E G ECL3N-term M E K K C T L N F L V L L P F F M I L V T A E L E E S P E D S I Q L G V T R N K I M T A Q Y E C Y Q K I M Q D P I Q Q A E G V Y C N R T W D G W L C W N D V A A G T E S M Q L C P D Y F Q D F D P S E K V T K I C D Q D G N W F R H P A S N R T W T N Y T Q C N V N-termC-term E A L R S A S Y T V S T I S D G P G Y S H D C P S E H L N G K S I H D I E N V L L K P E N L Y N C-term N T H E K V K T A L N L F Y L T I I G H G L S I A S L L I S L G I F F Y F C Q R I T L H K N L F F S F V C N S V V T I I H L T A V V S C K V S Q F I H L Y L M G C N Y F W M L C E G I Y L H T L I V V H L M W Y Y F L G W G F P L I P A C I H A I A R S L Y Y T H L L Y I I H G P I C A A L L V N L F F L L N I V R V L I T K L K Y M K A V R A T L I L V P L L G I E F V L I P W K I A E E V Y D Y I M H I L M H F Q G L L V S T I F C F F N G E L R R Y K I S F S V Q A I N W N Q Q F G N N S
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Residue Table


GPCRdb(A)
GPCRdb(B)
calcitonin receptor-like receptor
TM1
1x29 1.33x33 V135
1x33 1.37x37 L139
1x36 1.40x40 F142
TM2
2x61 2.68x68 L195
TM3
3x36 3.40x40 M223
ECL2
45x52 45.52x52 I284
TM5
5x42 5.37x38 Y292
5x44 5.40x40 H295
TM7
7x41 7.46x45 M373