Structure information

NK1 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

6E59

SPECIES

Homo sapiens

RESOLUTION

3.400

PREFERRED CHAIN

A

REFERENCE

10.1073/PNAS.1812717115

PUBLICATION DATE

Dec. 12, 2018

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
L760735 F90 2.62x62 TM2 hydrophobic
L760735 P112 3.32x32 TM3 polar (hydrogen bond with backbone)
L760735 P112 3.32x32 TM3 Van der Waals
L760735 I113 3.33x33 TM3 polar (hydrogen bond with backbone)
L760735 I113 3.33x33 TM3 Van der Waals
L760735 V116 3.36x36 TM3 Van der Waals
L760735 V116 3.36x36 TM3 hydrophobic
L760735 Q165 4.60x61 TM4 polar (hydrogen bond)
L760735 Q165 4.60x61 TM4 polar (hydrogen bond)
L760735 E193 5.35x36 TM5 Van der Waals
L760735 H197 5.39x40 TM5 Van der Waals
L760735 T201 5.43x44 TM5 Van der Waals
L760735 I204 5.46x461 TM5 Van der Waals
L760735 W261 6.48x48 TM6 aromatic (edge-to-face)
L760735 W261 6.48x48 TM6 Van der Waals
L760735 F264 6.51x51 TM6 hydrophobic
L760735 F264 6.51x51 TM6 Van der Waals
L760735 H265 6.52x52 TM6 Van der Waals
L760735 F268 6.55x55 TM6 hydrophobic
L760735 F268 6.55x55 TM6 Van der Waals

Ligands

L760735

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Residue Diagrams

V N G V V S T V V I V T Y A A A W L V I 1 V N L A F A E A S M A A F N T V V N F T 2 A T M S Y I S A F V A A I P F F N H F K 3 T K V V I C V I W V L A L L L A F P Q 4 Y A Y G I V L L P L F Y I L V T V C I H Y 5 I V V V C T F A I C W L P F H I F F L L 6 I P N Y M T S S M A L W M I A L Y V Q 7
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ICL1 K R M R ICL1ECL1 E W Y Y ECL1ICL2 P L Q P R L ICL2ECL2 T T E T M P S R V V C M I E W P E H ECL2ICL3 S S D ICL3ECL3 P D L Y L K ECL3N-term M D N V L P V D S D L S P N I S T N T S E P N Q F V Q N-termC-term R C C P F I S A G D Y E G L E M K S T R Y L Q T Q G S V Y K V S R L E T T I S T V V G A H E E E P E D G P K A T P S S L D L T S N C S S R S D S K T M T E S F S F S S N V L S C-term P A W Q I V L W A A A Y T V I V V T S V V G N V V V M W I I L A H T V T N Y F L V N L A F A E A S M A A F N T V V N F T Y A V H N G L F Y C K F H N F F P I A A V F A S I Y S M T A V A F D R Y M A I I H S A T A T K V V I C V I W V L A L L L A F P Q G Y Y S P N K I Y E K V Y H I C V T V L I Y F L P L L V I G Y A Y T V V G I T L W A S E I P G D R Y H E Q V S A K R K V V K M M I V V V C T F A I C W L P F H I F F L L P Y I N K F I Q Q V Y L A I M W L A M S S T M Y N P I I Y C C L N D R F K H F R L G A F
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Residue Table


GPCRdb(A)
GPCRdb(A)
NK1 receptor
TM2
2x62 2.62x62 F90
TM3
3x32 3.32x32 P112
3x33 3.33x33 I113
3x36 3.36x36 V116
TM4
4x61 4.60x61 Q165
TM5
5x36 5.35x36 E193
5x40 5.39x40 H197
5x44 5.43x44 T201
5x461 5.46x461 I204
TM6
6x48 6.48x48 W261
6x51 6.51x51 F264
6x52 6.52x52 H265
6x55 6.55x55 F268