Structure information

PTH1 receptor

PROTEIN CLASS

Class B1 (Secretin)

PDB CODE

6FJ3

SPECIES

Homo sapiens

RESOLUTION

2.500

PREFERRED CHAIN

A

PUBLICATION DATE

Nov. 21, 2018

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
ePTH M32 N-term polar (hydrogen bond with backbone)
ePTH M32 N-term polar (hydrogen bond with backbone)
ePTH I38 N-term hydrophobic
ePTH L41 N-term hydrophobic
ePTH E111 N-term polar (charge-assisted hydrogen bond)
ePTH H114 N-term polar (hydrogen bond)
ePTH I115 N-term hydrophobic
ePTH I135 N-term hydrophobic
ePTH D137 N-term polar (charge-assisted hydrogen bond)
ePTH D137 N-term polar (charge-assisted hydrogen bond)
ePTH F138 N-term hydrophobic
ePTH T163 N-term polar (hydrogen bond with backbone)
ePTH T163 N-term polar (hydrogen bond with backbone)
ePTH L174 N-term polar (hydrogen bond with backbone)
ePTH F184 1.36x36 TM1 aromatic (edge-to-face)
ePTH Y195 1.47x47 TM1 polar (charge-assisted hydrogen bond)
ePTH R233 2.60x60 TM2 polar (charge-charge)
ePTH M240 2.67x67 TM2 hydrophobic
ePTH L244 2.71x71 TM2 hydrophobic
ePTH Y245 2.72x72 TM2 polar (hydrogen bond)
ePTH Y245 2.72x72 TM2 polar (hydrogen bond)
ePTH F288 3.36x36 TM3 hydrophobic
ePTH W352 45.51x51 ECL2 hydrophobic
ePTH L354 ECL2 hydrophobic
ePTH Y429 ECL3 polar (charge-assisted hydrogen bond)
ePTH E444 7.42x41 TM7 polar (charge-assisted hydrogen bond)
ePTH M445 7.43x42 TM7 hydrophobic
ePTH N448 7.46x45 TM7 polar (charge-assisted hydrogen bond)

Ligands

ePTH

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Residue Diagrams

T L S A L S V S Y G V T Y I M G L R D F 1 M H L F L S F M L R A V S I F V K D A V 2 V L I W Y Y N T A L F Y L F F T V A V R 3 Y L W G F T V G F W G L P A V F V A V W V 4 F L I F N L V I S A L I P V Q I I W K K N 5 L V L M P L F G V H Y I V F M A T 6 I A V F F G Q F S N F L M E Y H M Q V 7
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ICL1 R R L H ICL1ECL1 L D E A E R L T E E E L R A I A Q A P P P P A T A A A ECL1ICL2 A F F ICL2ECL2 N T G C W D L S S ECL2ICL3 R E T N A G R C ICL3ECL3 P Y T E V S ECL3N-term M G T A R I A P G L A L L L C C P V L S S A Y A L V D A D D V M T K E E Q I F L L H R A Q A Q C E K R L K E V L Q R P A S I M E S D K G W T S A S T S G K P R K D K A S G K L Y P E S E E D K E A P T G S R Y R G R P C L P E W D H I L C W P L G A P G E V V A V P C P D Y I Y D F N H K G H A Y R R C D R N G S W E L V P G H N R T W A N Y S E C V K N-termC-term S G S S S Y S Y G P M V S H T S V T N V G P R V G L G L P L S P R L L P T A T T N G H P Q L P G H A K P G T P A L E T L E T T P P A M A A P K D D G F L N G S C S G L D E E A S G P E R P P A L L Q E E W E T V M C-term F L T N E T R E R E V F D R L G M I Y T V G Y S V S L A S L T V A V L I L A Y F C T R N Y I H M H L F L S F M L R A V S I F V K D A V L Y S G A T G Y A G C R V A V T F F L Y F L A T N Y Y W I L V E G L Y L H S L I F M S E K K Y L W G F T V F G W G L P A V F V A V W V S V R A T L A G N K K W I I Q V P I L A S I V L N F I L F I N I V R V L A T K L D T R Q Q Y R K L L K S T L V L M P L F G V H Y I V F M A T G T L W Q V Q M H Y E M L F N S F Q G F F V A I I Y C F C N G E I K K W T L K R K V Q A E S W S R A L D F A R
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Residue Table


GPCRdb(A)
GPCRdb(B)
PTH1 receptor
TM1
1x32 1.36x36 F184
1x43 1.47x47 Y195
TM2
2x53 2.60x60 R233
2x60 2.67x67 K240
2x64 2.71x71 L244
2x65 2.72x72 Y245
TM3
3x32 3.36x36 F288
ECL2
45x51 45.51x51 W352
TM7
7x37 7.42x41 E444
7x38 7.43x42 M445
7x41 7.46x45 N448