Structure information

β1-adrenoceptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

6H7M

SPECIES

Meleagris gallopavo

RESOLUTION

2.760

PREFERRED CHAIN

A

REFERENCE

10.1126/SCIENCE.AAU5595

PUBLICATION DATE

Oct. 17, 2018

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
levosalbutamol W117 3.28x28 TM3 hydrophobic
levosalbutamol D121 3.32x32 TM3 polar (charge-assisted hydrogen bond)
levosalbutamol V122 3.33x33 TM3 Van der Waals
levosalbutamol V122 3.33x33 TM3 hydrophobic
levosalbutamol V125 3.36x36 TM3 hydrophobic
levosalbutamol V125 3.36x36 TM3 Van der Waals
levosalbutamol F201 45.52x52 ECL2 hydrophobic
levosalbutamol F201 45.52x52 ECL2 Van der Waals
levosalbutamol Y207 5.38x39 TM5 Van der Waals
levosalbutamol S211 5.42x43 TM5 polar (hydrogen bond)
levosalbutamol S211 5.42x43 TM5 polar (hydrogen bond with backbone)
levosalbutamol S215 5.46x461 TM5 polar (hydrogen bond)
levosalbutamol F306 6.51x51 TM6 Van der Waals
levosalbutamol F306 6.51x51 TM6 aromatic (edge-to-face)
levosalbutamol F307 6.52x52 TM6 aromatic (edge-to-face)
levosalbutamol F307 6.52x52 TM6 Van der Waals
levosalbutamol N310 6.55x55 TM6 Van der Waals
levosalbutamol N329 7.39x38 TM7 polar (hydrogen bond)
levosalbutamol N329 7.39x38 TM7 polar (hydrogen bond)
levosalbutamol N329 7.39x38 TM7 Van der Waals
levosalbutamol Y333 7.43x42 TM7 Van der Waals

Ligands

levosalbutamol

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Residue Diagrams

V N G A V I L L V V L A M L L S M G A E 1 T S L A C A D L V M G L L V V P F G A T L 2 V C L T E I S A T V C L V D L S T W C E 3 A K V I I C T V W A I S A L V S F L P I 4 Y V F I M I L L P I Y F S I I S S A I A Y 5 G I I M G V F T L C W L P F F L V N I V 6 I P N F A S N A Y G L W N F F V F L W 7
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ICL1 Q R L Q ICL1ECL1 T W L W ECL1ICL2 P F R Y Q S L M ICL2ECL2 W W R D E D P Q A L K C Y Q D P G C C D F V T ECL2ICL3 G R F Y G S Q E Q P Q P P P L P Q H Q P I L G N G R A S K ICL3ECL3 R D L V ECL3N-term M G D G W L P P D C G P H N R S G G G G A T A A P T G S R Q V S N-termC-term F P R K A D R R L H A G G Q P A P L P G G F I S T L G S P E H S P G G T W S D C N G G T R G G S E S S L E E R H S K T S R S E S K M E R E K N I L A T T R F Y C T F L G N G D K A V F C T V L R I V K L F E D A T C T C P H T H K L K M K W R F K Q H Q A C-term A E L L S Q Q W E A G M S L L M A L V V L L I V A G N V L V I A A I G R T T L T N L F I T S L A C A D L V M G L L V V P F G A T L V V R G G S F L C E C W T S L D V L C V T A S I E T L C V I A I D R Y L A I T S T R A R A K V I I C T V W A I S A L V S F L P I M M H N R A Y A I A S S I I S F Y I P L L I M I F V Y L R V Y R E A K E Q I R K I D R C E R K T S R V M A M R E H K A L K T L G I I M G V F T L C W L P F F L V N I V N V F N P D W L F V F F N W L G Y A N S A F N P I I Y C R S P D F K R F R K A L L C
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Residue Table


GPCRdb(A)
GPCRdb(A)
β1-adrenoceptor
TM3
3x28 3.28x28 W117
3x32 3.32x32 D121
3x33 3.33x33 V122
3x36 3.36x36 V125
ECL2
45x52 45.52x52 F201
TM5
5x39 5.38x39 Y207
5x43 5.42x43 S211
5x461 5.46x461 S215
TM6
6x51 6.51x51 F306
6x52 6.52x52 F307
6x55 6.55x55 N310
TM7
7x38 7.39x38 N329
7x42 7.43x42 Y333