Structure information

NK1 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

6HLP

SPECIES

Homo sapiens

RESOLUTION

2.200

PREFERRED CHAIN

A

PUBLICATION DATE

Jan. 16, 2019

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
Netupitant N89 2.61x61 TM2 polar (hydrogen bond)
Netupitant N89 2.61x61 TM2 polar (hydrogen bond)
Netupitant P112 3.32x32 TM3 hydrophobic
Netupitant I113 3.33x33 TM3 hydrophobic
Netupitant Q165 4.60x61 TM4 polar (hydrogen bond)
Netupitant H197 5.39x40 TM5 aromatic (face-to-edge)
Netupitant F264 6.51x51 TM6 hydrophobic
Netupitant F268 6.55x55 TM6 hydrophobic
Netupitant M295 7.43x42 TM7 polar (hydrogen bond)
Netupitant M295 7.43x42 TM7 polar (hydrogen bond)

Ligands

Netupitant

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Residue Diagrams

V N G V V S T V V I V T Y A A A W L V I 1 V N L A F A E A S M A A F N T V V N F T 2 A T M S Y I S A F V A A I P F F N H F K 3 T K V V I C V I W V L A L L L A F P Q 4 Y A Y G I V L L P L F Y I L V T V C I H Y 5 I V V V C T F A I C W L P F H I F F L L 6 I P N Y M T S S M A L W M I A L Y V Q 7
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ICL1 K R M R ICL1ECL1 E W Y Y ECL1ICL2 P L Q P R L ICL2ECL2 T T E T M P S R V V C M I E W P E H ECL2ICL3 S S D ICL3ECL3 P D L Y L K K ECL3N-term M D N V L P V D S D L S P N I S T N T S E P N Q F V Q N-termC-term R C C P F I S A G D Y E G L E M K S T R Y L Q T Q G S V Y K V S R L E T T I S T V V G A H E E E P E D G P K A T P S S L D L T S N C S S R S D S K T M T E S F S F S S N V L S C-term P A W Q I V L W A A A Y T V I V V T S V V G N V V V M W I I L A H T V T N Y F L V N L A F A E A S M A A F N T V V N F T Y A V H N G L F Y C K F H N F F P I A A V F A S I Y S M T A V A F D R Y M A I I H S A T A T K V V I C V I W V L A L L L A F P Q G Y Y S P N K I Y E K V Y H I C V T V L I Y F L P L L V I G Y A Y T V V G I T L W A S E I P G D R Y H E Q V S A K R K V V K M M I V V V C T F A I C W L P F H I F F L L P Y I N F I Q Q V Y L A I M W L A M S S T M Y N P I I Y C C L N D R F K H F R L G A F
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Residue Table


GPCRdb(A)
GPCRdb(A)
NK1 receptor
TM2
2x61 2.61x61 N89
TM3
3x32 3.32x32 P112
3x33 3.33x33 I113
TM4
4x61 4.60x61 Q165
TM5
5x40 5.39x40 H197
TM6
6x51 6.51x51 F264
6x55 6.55x55 F268
TM7
7x42 7.43x42 M295