Structure information

TP receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

6IIU

SPECIES

Homo sapiens

RESOLUTION

2.500

PREFERRED CHAIN

A

PUBLICATION DATE

Dec. 19, 2018

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
ramatroban F34 1.42x42 TM1 hydrophobic
ramatroban L78 2.54x54 TM2 polar (hydrogen bond with backbone)
ramatroban T81 2.57x56 TM2 polar (hydrogen bond)
ramatroban T81 2.57x56 TM2 polar (hydrogen bond)
ramatroban V85 2.61x60 TM2 hydrophobic
ramatroban H89 2.65x64 TM2 polar (charge-assisted hydrogen bond)
ramatroban M112 3.32x32 TM3 polar (hydrogen bond with backbone)
ramatroban S181 ECL2 polar (charge-assisted hydrogen bond)
ramatroban W258 6.48x48 TM6 hydrophobic
ramatroban L294 7.39x38 TM7 hydrophobic
ramatroban R295 7.40x39 TM7 polar (charge-charge)
ramatroban Q301 7.46x46 TM7 polar (hydrogen bond)

Ligands

ramatroban

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Residue Diagrams

L N S A L G V V C F S A A F W P S 1 C G L V L T D F L G L V L T G T I V V S Q 2 A A G L L L P S L G F F I M V V G M F R 3 A W A T V G L V W A A A L A L G L L P L 4 N L L F S L G V S L G G L M S F L L G F 5 L L G I M V V A V S C W L P L L V F I A Q 6 W P D L I Q N W T A V R L Y I L L E K 7
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ICL1 G G S H T R ICL1ECL1 L F E W H A V D P G ECL1ICL2 P F S R P A V A ICL2ECL2 V G R Y T V Q Y P G S W C F L T L G A ECL2ICL3 E A A Q ICL3ECL3 N P P A M S P A G Q L ECL3N-term M W P N G S S L G P C F R P T N I T L E E R R L I A N-termC-term L Q P Q L T Q R S G L Q C-term S P W F A A S F C V V G L A S N L L A L S V L A G A R Q S S F L T F L C G L V L T D F L G L L V T G T I V V S Q H A A C R L C R F M G V V M I F F G L S P L L L G A A M A S E R Y L G I T R S Q R R A W A T V G L V W A A A L A L G L L P L L G E S G D V A F G L L F S M L G G L S V G L S F L L N T V S V A T L C H V Y H G Q Q R P R D S E V E M M A Q L L G I M V V A S V C W L P L L V F I A Q T V L R S R T T E K E L L I Y L R V A T W N Q I L D P W V Y I L F R R A L Q P R P R V L R R R L S T S L S
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Residue Table


GPCRdb(A)
GPCRdb(A)
TP receptor
TM1
1x42 1.42x42 F34
TM2
2x54 2.54x54 L78
2x56 2.57x56 T81
2x60 2.61x60 V85
2x64 2.65x64 H89
TM3
3x32 3.32x32 M112
TM6
6x48 6.48x48 W258
TM7
7x38 7.39x38 L294
7x39 7.40x39 R295
7x46 7.46x46 Q301