Structure information

D4 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

6IQL

SPECIES

Mus musculus

RESOLUTION

3.500

PREFERRED CHAIN

A

REFERENCE

10.7554/ELIFE.48822

PUBLICATION DATE

Dec. 4, 2019

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
L745870 F88 2.61x60 TM2 hydrophobic
L745870 W98 23.50x50 ECL1 hydrophobic
L745870 M109 3.29x29 TM3 hydrophobic
L745870 D112 3.32x32 TM3 polar (charge-assisted hydrogen bond)
L745870 V113 3.33x33 TM3 Van der Waals
L745870 V113 3.33x33 TM3 hydrophobic
L745870 F330 6.51x51 TM6 hydrophobic
L745870 F330 6.51x51 TM6 Van der Waals
L745870 F331 6.52x52 TM6 Van der Waals
L745870 F331 6.52x52 TM6 aromatic (face-to-edge)
L745870 H334 6.55x55 TM6 Van der Waals
L745870 Y358 7.43x42 TM7 Van der Waals

Ligands

L745870

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Residue Diagrams

S N G A L V L G I L L V G G V L A A A G 1 V S L A A A D L L L A L V V L P L F V Y S 2 A C L N F I S A T C L M V D M A M L T D 3 Q L L L I A A T W L L S A A V A S P V 4 Y L L L M L P C P L F F S C V S S Y V V Y 5 P V V V G A F L V C W T P F F V V H I T 6 I P N L A S N V Y G L W T V A S V L R 7
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ICL1 R T L Q ICL1ECL1 G V W L L ECL1ICL2 P L R Y ICL2ECL2 L N D V P G R D P A V C C L E ECL2ICL3 H S R A P R R P S G P G P P V S D P T Q G P F F P D C P P P L P S L R T S P S D S S R P E S E L S Q R P C S P G C L L A D A A L P Q P P E P S S R R R R G ICL3ECL3 P A C F V ECL3N-term M G N S S A T E D G G L L A G R G P E S L G T G A G L N-termC-term L R C C-term G G A G A A A L V G G V L L I G L V L A G N S L V C V S V A S E T P T N Y F I V S L A A A D L L L A V L V L P L F V Y S E V Q G S P R L C D T L M A M D V M L C T A S I F N L C A I S V D R F V A V T V N Q Q G Q C Q L L L I A A T W L L S A A V A S P V V C G N R D Y V V Y S S V C S F F L P C P L M L L L Y W A T F R G L R R W E A A R H T K L A K I T G R E R K A M R V L P V V V G A F L V C W T P F F V V H I T R A L C S P R L V S A V T W L G Y V N S A L N P I I Y T I F N A E F R K F R S V T L R
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Residue Table


GPCRdb(A)
GPCRdb(A)
D4 receptor
TM2
2x60 2.61x60 F88
ECL1
23x50 23.50x50 W98
TM3
3x29 3.29x29 M109
3x32 3.32x32 D112
3x33 3.33x33 V113
TM6
6x51 6.51x51 F330
6x52 6.52x52 F331
6x55 6.55x55 H334
TM7
7x42 7.43x42 Y358