Structure information

ETB receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

6K1Q

SPECIES

Homo sapiens

RESOLUTION

2.700

PREFERRED CHAIN

A

REFERENCE

10.1038/S42003-019-0482-7

PUBLICATION DATE

July 17, 2019

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
IRL 2500 H150 2.53x53 TM2 aromatic (face-to-face)
IRL 2500 N158 2.61x60 TM2 polar (hydrogen bond)
IRL 2500 K161 2.64x63 TM2 Van der Waals
IRL 2500 W167 23.50x50 ECL1 Van der Waals
IRL 2500 W167 23.50x50 ECL1 hydrophobic
IRL 2500 V177 3.28x28 TM3 Van der Waals
IRL 2500 V177 3.28x28 TM3 hydrophobic
IRL 2500 P178 3.29x29 TM3 Van der Waals
IRL 2500 P178 3.29x29 TM3 hydrophobic
IRL 2500 Q181 3.32x32 TM3 polar (hydrogen bond)
IRL 2500 Q181 3.32x32 TM3 polar (hydrogen bond)
IRL 2500 K182 3.33x33 TM3 polar (charge-assisted hydrogen bond)
IRL 2500 S184 3.35x35 TM3 Van der Waals
IRL 2500 V185 3.36x36 TM3 hydrophobic
IRL 2500 V185 3.36x36 TM3 Van der Waals
IRL 2500 T188 3.39x39 TM3 Van der Waals
IRL 2500 F240 4.64x65 TM4 Van der Waals
IRL 2500 F240 4.64x65 TM4 aromatic (face-to-edge)
IRL 2500 L277 5.42x43 TM5 Van der Waals
IRL 2500 L277 5.42x43 TM5 hydrophobic
IRL 2500 Y281 5.46x461 TM5 hydrophobic
IRL 2500 Y281 5.46x461 TM5 Van der Waals
IRL 2500 W336 6.48x48 TM6 Van der Waals
IRL 2500 W336 6.48x48 TM6 aromatic (edge-to-face)
IRL 2500 L339 6.51x51 TM6 Van der Waals
IRL 2500 L339 6.51x51 TM6 hydrophobic
IRL 2500 H340 6.52x52 TM6 Van der Waals
IRL 2500 R343 6.55x55 TM6 polar (charge-assisted hydrogen bond)
IRL 2500 A375 7.42x41 TM7 hydrophobic
IRL 2500 A375 7.42x41 TM7 Van der Waals
IRL 2500 S376 7.43x42 TM7 Van der Waals
IRL 2500 N378 7.45x45 TM7 Van der Waals
IRL 2500 S379 7.46x46 TM7 Van der Waals

Ligands

IRL 2500

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Residue Diagrams

S N G I I G L V F V L C S V V T N I Y K 1 A S L A L G D L L H I I V D I P I N V Y K 2 A C L S L V T I G V S A K Q I F P V L K 3 T A V E I V L I W V V S V V L A V P E 4 Y F F A T I A L P L C F Y F S F L W W D K 5 F C L V L V F A L C W L P L H L S R I L 6 I P N I C S N L S A M N I G I Y D L V 7
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ICL1 K C M R N ICL1ECL1 E D W P F ECL1ICL2 W S R I K G I G ICL2ECL2 D I I T M D Y K G S Y L R I C L L H P V Q K ECL2ICL3 Q I A L ICL3ECL3 N Q N D P N ECL3N-term M Q P P P S L C G R A L V A L V L A C G L S R I W G E E R G F P P D R A T P L L Q T A E I M T P P T K T L W P K G S N A S L A R S L A P A E V P K G D R T A G S P P R T I S P P P C N-termC-term W C Q S F E E K Q S L E E K Q S C L K F K A N D H G Y D N F R S S N K Y S S S C-term Q G P I E I K E T F K Y I N T V V S C L V F V L G I I G N S T L L R I I Y K N G P N I L I A S L A L G D L L H I V I D I P I N V Y K L L A G A E M C K L V P F I Q K A S V G I T V L S L C A L S I D R Y R A V A S V P K W T A V E I V L I W V V S V V L A V P E A I G F T A F M Q F Y K T A K D W W L F S F Y F C L P L A I T A F F Y T L M T C E M L R K K S G M N D H L K Q R R E V A K T V F C L V L V F A L C W L P L H L S R I L K L T L Y R C E L L S F L L V L D Y I G I N M A S L N S C I N P I A L Y L V S K R F K S F K N C C L C C
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Residue Table


GPCRdb(A)
GPCRdb(A)
ETB receptor
TM2
2x53 2.53x53 H150
2x60 2.61x60 N158
2x63 2.64x63 K161
ECL1
23x50 23.50x50 W167
TM3
3x28 3.28x28 V177
3x29 3.29x29 P178
3x32 3.32x32 Q181
3x33 3.33x33 K182
3x35 3.35x35 S184
3x36 3.36x36 V185
3x39 3.39x39 T188
TM4
4x65 4.64x65 F240
TM5
5x43 5.42x43 L277
5x461 5.46x461 Y281
TM6
6x48 6.48x48 W336
6x51 6.51x51 L339
6x52 6.52x52 H340
6x55 6.55x55 R343
TM7
7x41 7.42x41 A375
7x42 7.43x42 S376
7x45 7.45x45 N378
7x46 7.46x46 S379